{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:08:05Z","timestamp":1756253285751,"version":"3.44.0"},"reference-count":67,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004001","name":"Guizhou Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["[2023] General 265","LC [2021] 019","ZK [2021] General 423","ZK [2023] General 529"],"award-info":[{"award-number":["[2023] General 265","LC [2021] 019","ZK [2021] General 423","ZK [2023] General 529"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871261"],"award-info":[{"award-number":["31871261"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2025,8,26]]},"DOI":"10.1021\/acsomega.5c04236","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T15:25:58Z","timestamp":1755098758000},"page":"37674-37686","source":"Crossref","is-referenced-by-count":0,"title":["Effect of G83R Mutation on Transthyretin Protein Structural Stability"],"prefix":"10.1021","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2681-8436","authenticated-orcid":true,"given":"Xingwang","family":"Chen","sequence":"first","affiliation":[{"name":"Suzhou Medical College","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]},{"name":"Department of Ophthalmology","place":["Zunyi, China"]},{"name":"Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]},{"name":"Guizhou Eye Hospital","place":["Zunyi, China"]},{"name":"Guizhou Provincial Branch of National Eye Disease Clinical Research Center","place":["Zunyi, China"]},{"name":"Special Key Laboratory of Ocular Diseases of Guizhou Province","place":["Zunyi, China"]},{"name":"Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology","place":["Zunyi, China"]},{"name":"Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]},{"name":"Guizhou Eye Hospital","place":["Zunyi, China"]},{"name":"Guizhou Provincial Branch of National Eye Disease Clinical Research Center","place":["Zunyi, China"]},{"name":"Special Key Laboratory of Ocular Diseases of Guizhou Province","place":["Zunyi, China"]},{"name":"Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Nie","sequence":"additional","affiliation":[{"name":"Suzhou Medical College","place":["Suzhou, China"]},{"name":"Soochow University","place":["Suzhou, China"]},{"name":"Department of Ophthalmology","place":["Zunyi, China"]},{"name":"The Second Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yege","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology","place":["Zunyi, China"]},{"name":"Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]},{"name":"Guizhou Eye Hospital","place":["Zunyi, China"]},{"name":"Guizhou Provincial Branch of National Eye Disease Clinical Research Center","place":["Zunyi, China"]},{"name":"Special Key Laboratory of Ocular Diseases of Guizhou Province","place":["Zunyi, China"]},{"name":"Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology","place":["Zunyi, China"]},{"name":"Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]},{"name":"Guizhou Eye Hospital","place":["Zunyi, China"]},{"name":"Guizhou Provincial Branch of National Eye Disease Clinical Research Center","place":["Zunyi, China"]},{"name":"Special Key Laboratory of Ocular Diseases of Guizhou Province","place":["Zunyi, China"]},{"name":"Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology","place":["Zunyi, China"]},{"name":"Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]},{"name":"Guizhou Eye Hospital","place":["Zunyi, China"]},{"name":"Guizhou Provincial Branch of National Eye Disease Clinical Research Center","place":["Zunyi, China"]},{"name":"Special Key Laboratory of Ocular Diseases of Guizhou Province","place":["Zunyi, China"]},{"name":"Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology","place":["Zunyi, China"]},{"name":"Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]},{"name":"Guizhou Eye Hospital","place":["Zunyi, China"]},{"name":"Guizhou Provincial Branch of National Eye Disease Clinical Research Center","place":["Zunyi, China"]},{"name":"Special Key Laboratory of Ocular Diseases of Guizhou Province","place":["Zunyi, China"]},{"name":"Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology","place":["Zunyi, China"]},{"name":"Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]},{"name":"Guizhou Eye Hospital","place":["Zunyi, China"]},{"name":"Guizhou Provincial Branch of National Eye Disease Clinical Research Center","place":["Zunyi, China"]},{"name":"Special Key Laboratory of Ocular Diseases of Guizhou Province","place":["Zunyi, China"]},{"name":"Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanjun","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology","place":["Zunyi, China"]},{"name":"Affiliated Hospital of Zunyi Medical University","place":["Zunyi, China"]},{"name":"Guizhou Eye Hospital","place":["Zunyi, China"]},{"name":"Guizhou Provincial Branch of National Eye Disease Clinical Research Center","place":["Zunyi, China"]},{"name":"Special Key Laboratory of Ocular Diseases of Guizhou Province","place":["Zunyi, China"]},{"name":"Zunyi Medical University","place":["Zunyi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(78)90368-6"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101039"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-37-3-415"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12704"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.2174\/092986712800269335"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000791"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.1c00073"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13035"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101024200"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/bi011194d"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1006-7876.2019.05.006"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-9125-z"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001094"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2023.2257521"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51328"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-019-1235-x"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-024-07765-5"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.168048"},{"issue":"05","key":"ref19\/cit19","first-page":"482","volume":"27","author":"Shi Y.","year":"2011","journal-title":"Chin. J. Ocul. Fundus Dis."},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3109\/13816810.2011.599356"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12196"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1091183"},{"issue":"04","key":"ref23\/cit23","first-page":"221","volume":"23","author":"Cheng C.","year":"2017","journal-title":"Chin. J. Hepato Surg."},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.12102\/j.issn.1672-1349.2019.06.047"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-024-03445-y"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.217"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1002\/ana.27203"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.10"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2023.07.14"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1003-9406.2012.01.004"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1005-1015.2013.01.025"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.2095-0160.2013.05.013"},{"key":"ref33\/cit33","first-page":"1631","volume":"19","author":"Zhang A. M.","year":"2013","journal-title":"Mol. Vis."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1005-1015.2016.03.021"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13425"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.821003"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.972501"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn511434-20201231-00653"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac439"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3942"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky300"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2013.03.005"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/bi500739q"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/bi952501g"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/bi049621l"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.2174\/1389203715666140327114232"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2019.00041"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179652"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.06.019"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0310364"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202495199"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00700"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01698"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2554"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249742"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043729"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2018.10.013"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.07.029"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-022-02481-9"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-5928(03)00069-X"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082484"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.3109\/00365548909035704"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2023.2185755"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23669"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/bi201365r"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/bi027319b"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.01.018"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c04236","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c04236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T08:16:24Z","timestamp":1756196184000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c04236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,13]]},"references-count":67,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2025,8,26]]}},"alternative-id":["10.1021\/acsomega.5c04236"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c04236","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"type":"print","value":"2470-1343"},{"type":"electronic","value":"2470-1343"}],"subject":[],"published":{"date-parts":[[2025,8,13]]}}}