{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:50:51Z","timestamp":1791993051634,"version":"4.4.0"},"reference-count":76,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","award":["81Z0300117"],"award-info":[{"award-number":["81Z0300117"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","award":["81Z0300502"],"award-info":[{"award-number":["81Z0300502"]}],"id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2025,9,30]]},"DOI":"10.1021\/acsomega.5c04399","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T09:16:01Z","timestamp":1758100561000},"page":"43831-43854","source":"Crossref","is-referenced-by-count":1,"title":["Multitargeted Caffeic Acid Derivatives Inhibit Cardiac RyR2- and Na<sub>V<\/sub>1.5- Channels but Stimulate SERCA2a Pump Activity"],"prefix":"10.1021","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-6981","authenticated-orcid":true,"given":"Gyuzel Y.","family":"Mitronova","sequence":"first","affiliation":[{"name":"Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 G\u00f6ttingen, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research)","place":["G\u00f6ttingen, Germany"]},{"name":"Partner Site Lower Saxony","place":["G\u00f6ttingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9101-3488","authenticated-orcid":true,"given":"Christine","family":"Quentin","sequence":"additional","affiliation":[{"name":"Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7741-4653","authenticated-orcid":true,"given":"Vladimir N.","family":"Belov","sequence":"additional","affiliation":[{"name":"Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila A.","family":"Kiszka","sequence":"additional","affiliation":[{"name":"Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, 37077 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8129-1537","authenticated-orcid":true,"given":"J\u00f6rg W.","family":"Wegener","sequence":"additional","affiliation":[{"name":"DZHK (German Centre for Cardiovascular Research)","place":["G\u00f6ttingen, Germany"]},{"name":"Partner Site Lower Saxony","place":["G\u00f6ttingen, Germany"]},{"name":"Department of Translational Pharmacology, Medical School OWL, Bielefeld University, Universit\u00e4tsstra\u00dfe 25, 33615 Bielefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan E.","family":"Lehnart","sequence":"additional","affiliation":[{"name":"Department of Cardiology & Pulmonology, Heart Research Center G\u00f6ttingen, University Medical Center G\u00f6ttingen, Robert-Koch-Strasse 42a, 37075 G\u00f6ttingen, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research)","place":["G\u00f6ttingen, Germany"]},{"name":"Partner Site Lower Saxony","place":["G\u00f6ttingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.70.113006.100455"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI162891"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.03.005"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020911-153308"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan0724"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.07.030"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000125626.33738.E2"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37059"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20051214"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-0394-8"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00211.2013"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab123"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2013.46.5.077"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01235"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202302278"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35346"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094301"},{"key":"ref18\/cit18","unstructured":"Marks, A. R.; Landry, D. W.; Deng, S.; Zhuang, C. Z.; Lehnart, S. E. Agents for preventing and treating disorders involving modulation of the RyR receptors. U.S. patent US7,879,840 B2, February 1, 2011."},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo1272"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27165095"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000747272.04576.e2"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c04468"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.11.041"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.5339\/gcsp.2013.30"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2020.1854986"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/nature13950"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404719101"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.202213089"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26010203"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1177\/1087057116629669"},{"key":"ref31\/cit31","unstructured":"Roifman, C. M.; Simon, A. J.; Demin, P. M.; Rounova, O. B. Styrylacrylonitrile compounds, and preparation thereof, for the inhibition of vascular endothelial growth factor. WO2004032911, April 22, 2004."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/jo00170a070"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1039\/C1CC11345C"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201402614"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201604986"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.044"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129963"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2859-11-42"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00541"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2025.101219"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.595516"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117012"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201611624"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5153"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1124\/mol.117.111468"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/cpph.71"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-018-0103-x"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.2979"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-96217-7"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1177\/1087057112456878"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3791\/60017"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2006027117"},{"key":"ref53\/cit53","unstructured":"Corso, G.; St\u00e4rk, H.; Jing, B.; Barzilay, R.; Jaakkola, T. Diffdock: Diffusion steps, twists, and turns for molecular docking.  arXiv preprint 2022, arXiv:2210.01776."},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/ci300604z"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.1c00203"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202400763"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2013.12.007"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47310-6"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.08.062"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1955.sp005250"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202102196"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.25.15153"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/ci990307l"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-018-0283-x"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.92"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00282"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000180663.42594.aa"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00006"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2013.11.014"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00413"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.078782"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1038\/s41434-020-0171-7"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2629"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201402292"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201695709"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c04399","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c04399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T08:13:38Z","timestamp":1759220018000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c04399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":76,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2025,9,30]]}},"alternative-id":["10.1021\/acsomega.5c04399"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c04399","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,17]]}}}