{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:28:47Z","timestamp":1760488127049,"version":"build-2065373602"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007188","name":"Instituto Nacional de Pesquisas da Amaz\u00f4nia","doi-asserted-by":"publisher","award":["300465\/2017-3","300913\/2019-2","313061\/2015-7"],"award-info":[{"award-number":["300465\/2017-3","300913\/2019-2","313061\/2015-7"]}],"id":[{"id":"10.13039\/501100007188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","award":["13\/2022-Produtividade","2\/2018-Universal Amazonas - 062.01356\/2018","23\/2009-PRONEX\/FAPEAM\/CNPq - 062.01051\/2011","4\/2018-Amazonas Estratgico - 062.01380\/2018"],"award-info":[{"award-number":["13\/2022-Produtividade","2\/2018-Universal Amazonas - 062.01356\/2018","23\/2009-PRONEX\/FAPEAM\/CNPq - 062.01051\/2011","4\/2018-Amazonas Estratgico - 062.01380\/2018"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["105555\/2015-0","133139\/2016-6","312042\/2014-0","312883\/2017-0","461971\/2014-3"],"award-info":[{"award-number":["105555\/2015-0","133139\/2016-6","312042\/2014-0","312883\/2017-0","461971\/2014-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2025,10,14]]},"DOI":"10.1021\/acsomega.5c04736","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T03:09:41Z","timestamp":1759201781000},"page":"46832-46843","source":"Crossref","is-referenced-by-count":0,"title":["Chemical and Antiplasmodial Investigations on <i>Carapa<\/i>-Derived Gedunin Derivatives and Semisynthetic 6- and 7-Substituted Gedunin Analogues from the Brazilian Amazon"],"prefix":"10.1021","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9919-5327","authenticated-orcid":true,"given":"Tiago","family":"Barbosa Pereira","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias Exatas e da Terra, Programa de P\u00f3s-gradua\u00e7\u00e3o em Qu\u00edmica, Universidade Federal do Amazonas, Avenida General Rodrigo Ot\u00e1vio, 6200, Campus Universit\u00e1rio Senador Arthur Virg\u00edlio Filho, Setor Norte, Bloco 3 (ICE), Coroado I, CEP 69077-000 Manaus, Amazonas, Brazil"},{"name":"Instituto Nacional de Pesquisas da Amaz\u00f4nia, Coordena\u00e7\u00e3o de Tecnologia e Inova\u00e7\u00e3o, Avenida Andr\u00e9 Ara\u00fajo, 2936, Petr\u00f3polis,CEP 69067-375 Manaus, Amazonas , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9153-5345","authenticated-orcid":true,"given":"La\u00eds","family":"Garcia Jord\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas, Programa de P\u00f3s-gradua\u00e7\u00e3o em Biotecnologia, Universidade Federal do Amazonas, Avenida General Rodrigo Oct\u00e1vio Jord\u00e3o Ramos, 6200, Campus Universit\u00e1rio Senador Arthur Virg\u00edlio Filho, Setor Sul, Bloco M, Coroado I, CEP 69077-000 Manaus, Amazonas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0516-1126","authenticated-orcid":true,"given":"Djalma","family":"da Silva Pereira","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Exatas e da Terra, Programa de P\u00f3s-gradua\u00e7\u00e3o em Qu\u00edmica, Universidade Federal do Amazonas, Avenida General Rodrigo Ot\u00e1vio, 6200, Campus Universit\u00e1rio Senador Arthur Virg\u00edlio Filho, Setor Norte, Bloco 3 (ICE), Coroado I, CEP 69077-000 Manaus, Amazonas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7288-2466","authenticated-orcid":true,"given":"Gustavo","family":"Souza dos Santos","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Pesquisas da Amaz\u00f4nia, Coordena\u00e7\u00e3o de Tecnologia e Inova\u00e7\u00e3o, Avenida Andr\u00e9 Ara\u00fajo, 2936, Petr\u00f3polis,CEP 69067-375 Manaus, Amazonas , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4622-3270","authenticated-orcid":true,"given":"Daniel","family":"Soares dos Santos","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Pesquisas da Amaz\u00f4nia, Coordena\u00e7\u00e3o de Tecnologia e Inova\u00e7\u00e3o, Avenida Andr\u00e9 Ara\u00fajo, 2936, Petr\u00f3polis,CEP 69067-375 Manaus, Amazonas , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8692-0848","authenticated-orcid":true,"given":"Roberto","family":"Figliuolo","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Pesquisas da Amaz\u00f4nia, Coordena\u00e7\u00e3o de Tecnologia e Inova\u00e7\u00e3o, Avenida Andr\u00e9 Ara\u00fajo, 2936, Petr\u00f3polis,CEP 69067-375 Manaus, Amazonas , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2801-1609","authenticated-orcid":true,"given":"Jaqueline","family":"Siqueira da Costa","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Pesquisas da Amaz\u00f4nia, Coordena\u00e7\u00e3o de Sociedade, Ambiente e Sa\u00fade, Avenida Andr\u00e9 Ara\u00fajo, 2936, Petr\u00f3polis, CEP 69067-375 Manaus, Amazonas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-6056","authenticated-orcid":true,"given":"Leilane","family":"de Sousa Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Programa de P\u00f3s-gradua\u00e7\u00e3o em Inova\u00e7\u00e3o Farmac\u00eautica, Universidade Federal do Amazonas, Avenida General Rodrigo Oct\u00e1vio, 6200, Campus Universit\u00e1rio Senador Arthur Virg\u00edlio Filho, Mini-campus, Coroado I, CEP 69080-900 Manaus, Amazonas , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9367-2812","authenticated-orcid":true,"given":"Emersom","family":"Silva Lima","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Programa de P\u00f3s-gradua\u00e7\u00e3o em Inova\u00e7\u00e3o Farmac\u00eautica, Universidade Federal do Amazonas, Avenida General Rodrigo Oct\u00e1vio, 6200, Campus Universit\u00e1rio Senador Arthur Virg\u00edlio Filho, Mini-campus, Coroado I, CEP 69080-900 Manaus, Amazonas , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7785-4029","authenticated-orcid":true,"given":"Marne","family":"Carvalho de Vasconcellos","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas, Programa de P\u00f3s-gradua\u00e7\u00e3o em Inova\u00e7\u00e3o Farmac\u00eautica, Universidade Federal do Amazonas, Avenida General Rodrigo Oct\u00e1vio, 6200, Campus Universit\u00e1rio Senador Arthur Virg\u00edlio Filho, Mini-campus, Coroado I, CEP 69080-900 Manaus, Amazonas , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6793-3759","authenticated-orcid":true,"given":"Adrian Martin","family":"Pohlit","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Pesquisas da Amaz\u00f4nia, Coordena\u00e7\u00e3o de Tecnologia e Inova\u00e7\u00e3o, Avenida Andr\u00e9 Ara\u00fajo, 2936, Petr\u00f3polis,CEP 69067-375 Manaus, Amazonas , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114906"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2023.104629"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25030493"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1039\/jr9600003827"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1039\/jr9610003705"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/np50065a002"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(81)85229-6"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)98254-7"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00117-8"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.05.037"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(86)90156-X"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/np9605394"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2011.12.076"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-7348.2003.tb00279.x"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2007.08.001"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650040108"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1556487"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2010.535000"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/np100325q"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.2174\/1568026033392499"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/np0680230"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.01.020"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.01.020"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-317"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/0045-2068(73)90007-2"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)93014-5"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(75)85265-4"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-40422012001000009"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1039\/P19900002057"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1039\/jr9620005095"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2010.11.028"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.15012\/00001103"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.6b00744"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.2c00684"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/np0780093"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2011.11.028"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/np068021f"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.427328"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-280"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-018-0233-2"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.11.020"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-50532006000300017"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1126\/science.781840"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762007000300016"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.2307\/3280287"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90365-3"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(94)90396-4"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c04736","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c04736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T09:11:25Z","timestamp":1760433085000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c04736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":47,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2025,10,14]]}},"alternative-id":["10.1021\/acsomega.5c04736"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c04736","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"type":"print","value":"2470-1343"},{"type":"electronic","value":"2470-1343"}],"subject":[],"published":{"date-parts":[[2025,9,29]]}}}