{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:52:04Z","timestamp":1792525924861,"version":"4.5.0"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2021\/04464-8"],"award-info":[{"award-number":["2021\/04464-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2025,8,19]]},"DOI":"10.1021\/acsomega.5c04856","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T06:19:38Z","timestamp":1754547578000},"page":"36432-36440","source":"Crossref","is-referenced-by-count":1,"title":["Mechanistic Insights and Therapeutic Potential of the Antidepressant Amitriptyline against <i>Leishmania (Leishmania) amazonensis<\/i>"],"prefix":"10.1021","volume":"10","author":[{"given":"Juliana Tonini","family":"Mesquita","sequence":"first","affiliation":[{"name":"Pathophysiology Laboratory","place":["S\u00e3o Paulo, Brazil"]},{"name":"Instituto Butantan","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi Nosomi","family":"Taniwaki","sequence":"additional","affiliation":[{"name":"Electron Microscopy Nucleus","place":["S\u00e3o Paulo, Brazil"]},{"name":"Instituto Adolfo Lutz","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2559-7344","authenticated-orcid":true,"given":"Andre Gustavo","family":"Tempone","sequence":"additional","affiliation":[{"name":"Pathophysiology Laboratory","place":["S\u00e3o Paulo, Brazil"]},{"name":"Instituto Butantan","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4418-0838","authenticated-orcid":true,"given":"Juliana Quero","family":"Reim\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory of Preclinical Assays and Research of Alternative Sources of Innovative Therapy for Toxoplasmosis and Other Sicknesses (PARASITTOS)","place":["Jundia\u00ed, Brazil"]},{"name":"Faculdade de Medicina de Jundia\u00ed","place":["Jundia\u00ed, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"ref1\/cit1","unstructured":"World Health Organization (WHO).  Global leishmaniasis surveillance updates\n2023:3 years of the NTD road map. Weekly epidemiological record, 2023. https:\/\/www.who.int\/publications\/i\/item\/who-wer-9945-653-669."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02459-14"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11120.1"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.2741\/4629"},{"key":"ref5\/cit5","unstructured":"World Health Organization (WHO). Leishmaniasis. Appears in: Neglected\ntropical diseases, 2024. https:\/\/www.who.int\/data\/gho\/data\/themes\/topics\/gho-ntd-leishmaniasis."},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30171-4"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.622286"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14919"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(90)90210-C"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90293-3"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1454002"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005281"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910415"},{"key":"ref14\/cit14","unstructured":"DrugBank.  Amitriptyline, 2025. https:\/\/go.drugbank.com\/drugs\/DB00321."},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2013.02.007"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2022.106612"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-022-07594-5"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.21577\/0103-5053.20200197"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.08.055"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21725"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1523691"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2013.09.018"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01928-18"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.106009"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3390\/ph13110339"},{"key":"ref26\/cit26","unstructured":"DrugBank. Amphoterin B, 2025. https:\/\/go.drugbank.com\/drugs\/DB00681."},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.3.1225-1233.2003"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(86)90183-3"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(99)00133-8"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4097-4102.2004"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762011000800022"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg301"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410795200"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014666"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2016.01.002"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3109\/01913129209057832"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c04856","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c04856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T08:14:46Z","timestamp":1755591286000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c04856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,7]]},"references-count":36,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2025,8,19]]}},"alternative-id":["10.1021\/acsomega.5c04856"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c04856","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,7]]}}}