{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:09:48Z","timestamp":1790672988674,"version":"4.1.0"},"reference-count":54,"publisher":"American Chemical Society (ACS)","issue":"41","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007801","name":"Fundaci??n S??neca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient??ficas y T??cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["UBACYT 20020220300118BA"],"award-info":[{"award-number":["UBACYT 20020220300118BA"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"European Commission","doi-asserted-by":"publisher","award":["PRTR-C17.I1"],"award-info":[{"award-number":["PRTR-C17.I1"]}],"id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CYTED Programa de Ciencia y Tecnolog??a para el Desarrollo","award":["P123RT0138"],"award-info":[{"award-number":["P123RT0138"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2025,10,21]]},"DOI":"10.1021\/acsomega.5c05127","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:22:14Z","timestamp":1760041334000},"page":"48228-48241","source":"Crossref","is-referenced-by-count":2,"title":["A Promising Anti-dengue Virus Carboxylated-Sesquiterpene Lactone from <i>Stevia entreriensis<\/i> (Asteraceae)"],"prefix":"10.1021","volume":"10","author":[{"given":"Jimena","family":"Borgo","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica y Metabolismo del F\u00e1rmaco, (IQUIMEFA) CONICET-Universidad de Buenos Aires; C\u00e1tedra de Farmacognosia, Facultad de Farmacia y Bioqu\u00edmica","place":["Buenos Aires, Argentina"]},{"name":"Universidad de Buenos Aires","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-8072","authenticated-orcid":true,"given":"Alejandro","family":"Rodr\u00edguez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Structural Bioinformatics and High Performance Computing Research Group (BIO-HPC), HiTech Innovation Hub","place":["Murcia, Spain"]},{"name":"Universidad Cat\u00f3lica San Antonio de Murcia (UCAM)","place":["Murcia, Spain"]},{"name":"Health Sciences PhD Program","place":["Murcia, Spain"]},{"name":"Universidad Cat\u00f3lica de Murcia (UCAM)","place":["Murcia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariel S.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Laboratorio de Estrategias Antivirales, Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales","place":["Buenos Aires, Argentina"]},{"name":"Universidad de Buenos Aires","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto E.","family":"Bivona","sequence":"additional","affiliation":[{"name":"Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni (IDEHU), (Universidad de Buenos Aires- CONICET), Buenos Aires C1113AAD, Argentina; C\u00e1tedra de Inmunolog\u00eda, Facultad de Farmacia y Bioqu\u00edmica","place":["Buenos Aires, Argentina"]},{"name":"Universidad de Buenos Aires","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia S.","family":"Sep\u00falveda","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN)","place":["Buenos Aires, Argentina"]},{"name":"CONICET-Universidad de Buenos Aires","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar A. N.","family":"Catal\u00e1n","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica, Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia","place":["San Miguel de Tucum\u00e1n, Argentina"]},{"name":"Universidad Nacional de Tucum\u00e1n","place":["San Miguel de Tucum\u00e1n, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4468-7898","authenticated-orcid":true,"given":"Horacio","family":"P\u00e9rez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Structural Bioinformatics and High Performance Computing Research Group (BIO-HPC), HiTech Innovation Hub","place":["Murcia, Spain"]},{"name":"Universidad Cat\u00f3lica San Antonio de Murcia (UCAM)","place":["Murcia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9322-5748","authenticated-orcid":true,"given":"Valeria P.","family":"S\u00fclsen","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica y Metabolismo del F\u00e1rmaco, (IQUIMEFA) CONICET-Universidad de Buenos Aires; C\u00e1tedra de Farmacognosia, Facultad de Farmacia y Bioqu\u00edmica","place":["Buenos Aires, Argentina"]},{"name":"Universidad de Buenos Aires","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"issue":"1","key":"ref1\/cit1","first-page":"1","volume":"29","author":"Soejarto D. D.","year":"1983","journal-title":"Bot. Mus. Leafl., Harv. Univ."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-78274-4_1"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26092733"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/biom15020268"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107553"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1371002"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13010133"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27113492"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA08125K"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1039\/D2FO00933A"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14452"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-78274-4_12"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.2174\/1389201024666230327082051"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1590\/2175-7860201970078"},{"issue":"1","key":"ref15\/cit15","first-page":"15","volume":"16","author":"Camarero P. L. C.","year":"2000","journal-title":"Dominguezia"},{"issue":"1","key":"ref16\/cit16","first-page":"5","volume":"19","author":"Camarero P. C.","year":"2003","journal-title":"Dominguezia"},{"key":"ref17\/cit17","unstructured":"World Health\nOrganization (WHO). Dengue\nand severe dengue. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dengue-and-severe-dengue (accessed July 26, 2023)."},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11081328"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-38450-1"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1186\/1479-0556-10-6"},{"key":"ref21\/cit21","unstructured":"OPS\/OMS; Organizaci\u00f3n Panamericana de la Salud. Dengue. https:\/\/www.paho.org\/es\/temas\/dengue (accessed July 26, 2023)."},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/v13101967"},{"key":"ref23\/cit23","unstructured":"Drugs for Neglected Diseases iniative (DNDi). Dengue. https:\/\/dndi.org\/diseases\/dengue\/ (accessed July 7, 2023)."},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(81)83029-4"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-78274-4_7"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.18257\/raccefyn.22(83).1998.2904"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)97717-3"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(99)00150-8"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)81255-8"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29040814"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-78274-4_13"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/jm900776m"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2021.116415"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2022.113362"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.07.038"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247749"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2220005120"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2015.04.010"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3390\/v15030696"},{"key":"ref40\/cit40","unstructured":"ChEMBL Database. https:\/\/www.ebi.ac.uk\/chembl\/ (accessed March 22, 2024)."},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1072"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-3-33"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/ci049885e"},{"key":"ref45\/cit45","unstructured":"Bank, R. P. D. RCSB\nPDB - 4O6B: Dengue Type2 Virus Non-structural protein 1 (NS1) Form\n1 crystal. https:\/\/www.rcsb.org\/structure\/4o6b (accessed April 29, 2024)."},{"key":"ref46\/cit46","unstructured":"Bank, R. P. D. RCSB\nPDB - 2FOM: Dengue Virus NS2B\/NS3 Protease. https:\/\/www.rcsb.org\/structure\/2FOM (accessed April 29, 2024)."},{"key":"ref47\/cit47","unstructured":"Bank, R. P. D. RCSB PDB - 1R6A: Structure of the dengue virus 2\u2032O methyltransferase in complex with s-adenosyl homocysteine and ribavirin\n5\u2032 triphosphate. https:\/\/www.rcsb.org\/structure\/1r6a (accessed March 22, 2024)."},{"key":"ref48\/cit48","unstructured":"Bank, R. P. D. RCSB\nPDB - 1OKE: Crystal structure of the dengue 2 virus envelope protein\nin complex with n-octyl-beta-D-glucoside. https:\/\/www.rcsb.org\/structure\/1OKE (accessed April 29, 2024)."},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(80)80168-2"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-S14-S13"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-367"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2019.100241"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/ct7000045"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c05127","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c05127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:49:27Z","timestamp":1761036567000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c05127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,9]]},"references-count":54,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2025,10,21]]}},"alternative-id":["10.1021\/acsomega.5c05127"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c05127","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,9]]}}}