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In this work, the anaerobic digestion of vinasse and sugarcane molasses supplemented with filter cake was performed in a two-stage upflow anaerobic sludge blanket (UASB) reactors system (R1 and R2). A volumetric methane production (VMP) of up to 4.3 L CH4 (L d)\u22121 was obtained for R1 + R2, with the application of an organic loading rate (OLR) in R1 of up to 45.0 g total COD (L d)\u22121. However, for OLR values higher than those applied, a shock load was observed, and only after its reduction was it possible to obtain stability again in terms of the pH, alkalinity, and acidity values in the UASB reactors, R1 and R2, which highlights the robustness of these anaerobic systems. With the decrease in the OLR after the shock load, the genera Trichococcus and Methanosarcina prevailed over Bifidobacterium and Methanobacterium in the sludge of the UASB reactor (R1). The use of two-stage UASB reactors for the co-digestion of vinasse, molasses, and filter cake allowed the establishment of a maximum OLR for the operation of anaerobic reactors under stable conditions in terms of the production of biogas and quality effluent. This could help the sugar and energy industries to produce methane in a sustainable and optimized manner.<\/jats:p>","DOI":"10.1021\/acsomega.5c06244","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T23:00:29Z","timestamp":1787439629000},"page":"52372-52388","source":"Crossref","is-referenced-by-count":0,"title":["Co-Digestion of\nSugarcane Biorefinery Byproducts in\nUpflow Anaerobic Sludge Blanket Reactors, in Series, with Application\nof High Organic Loading Rate"],"prefix":"10.1021","volume":"11","author":[{"given":"Bruna R. S.","family":"Sturaro","sequence":"first","affiliation":[{"name":"Sa\u0303o Paulo State University (UNESP) , , , ,","place":["Jaboticabal, Sa\u0303o Paulo, Brazil, 14884-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-4534","authenticated-orcid":true,"given":"Lucas A. L.","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Sa\u0303o Paulo State University (UNESP) , , , ,","place":["Jaboticabal, Sa\u0303o Paulo, Brazil, 14884-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Sa\u0303o Paulo State University (UNESP) , , , ,","place":["Jaboticabal, Sa\u0303o Paulo, Brazil, 14884-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto A.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Sa\u0303o Paulo State University (UNESP) , , , ,","place":["Jaboticabal, Sa\u0303o Paulo, Brazil, 14884-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5691-1896","authenticated-orcid":true,"given":"Rose M.","family":"Duda","sequence":"additional","affiliation":[{"name":"Sa\u0303o Paulo State University (UNESP) , , , ,","place":["Jaboticabal, Sa\u0303o Paulo, Brazil, 14884-900"]},{"name":"Av. Eduardo Carlos Zambianchi , , n. 31, Vila Industrial , , ,","place":["Jaboticabal, Sa\u0303o Paulo, Brazil, 14883-130"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"2026090809091864800_cit1","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.rser.2016.05.022","article-title":"Solar Energy for Future World: - A Review","volume":"62","author":"Kannan","year":"2016","journal-title":"Renew. Sustain. Energy Rev."},{"key":"2026090809091864800_cit2","unstructured":"IEA.\n          . The global power mix is set to transform by 2030. https:\/\/www.iea.org\/energy-system\/renewables."},{"key":"2026090809091864800_cit3","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.biombioe.2017.09.011","article-title":"Energetic Shift\nof Sugarcane Bagasse Using Biogas Produced\nfrom Sugarcane Vinasse in Brazilian Ethanol Plants","volume":"107","author":"Joppert","year":"2017","journal-title":"Biomass Bioenergy"},{"key":"2026090809091864800_cit4","unstructured":"UNICA.\n          . Histo\u0301rico de produc\u0327a\u0303o\nde ac\u0327u\u0301car\ne ethanol. https:\/\/unicadata.com.br\/listagem.php?idMn=4 (accessed May 24, 2025)."},{"issue":"July","key":"2026090809091864800_cit5","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.biortech.2017.07.106","article-title":"Improved Methane\nProduction from\nSugarcane Vinasse with Filter Cake in Thermophilic UASB Reactors,\nwith Predominance of Methanothermobacter and Methanosarcina Archaea\nand Thermotogae Bacteria","volume":"244","author":"Barros","year":"2017","journal-title":"Bioresour. Technol."},{"issue":"2","key":"2026090809091864800_cit6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s13593-018-0490-x","article-title":"Sustainability of Sugarcane\nProduction\nin Brazil. A Review","volume":"38","author":"Bordonal","year":"2018","journal-title":"Agron. Sustain. 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Technol."},{"key":"2026090809091864800_cit25","doi-asserted-by":"publisher","first-page":"581984","DOI":"10.1155\/2013\/581984","article-title":"Filter Cake and\nVinasse as Fertilizers\nContributing to Conservation Agriculture","volume":"2013","author":"Prado","year":"2013","journal-title":"Appl.\nEnviron. Soil Sci."},{"key":"2026090809091864800_cit26","first-page":"13","article-title":"Physicochemical\nProperties of Sugarcane Industry Residues Aiming at Their Use in Energy\nProcesses","volume-title":"Sugarcane\u2500Biotechnology\nfor Biofuels","author":"Camargo","year":"2016"},{"issue":"July","key":"2026090809091864800_cit27","doi-asserted-by":"publisher","first-page":"128684","DOI":"10.1016\/j.jclepro.2021.128684","article-title":"Pros and Cons of\nFertirrigation with in Natura Sugarcane Vinasse: Do Improvements in\nSoil Fertility Offset Environmental and Bioenergy Losses?","volume":"319","author":"Fuess","year":"2021","journal-title":"J. Clean. Prod."},{"key":"2026090809091864800_cit28","doi-asserted-by":"publisher","first-page":"888","DOI":"10.1016\/j.rser.2015.01.023","article-title":"Anaerobic Digestion of Vinasse from\nSugarcane Ethanol Production in Brazil: Challenges and Perspectives","volume":"44","author":"Moraes","year":"2015","journal-title":"Renew. Sustain. Energy Rev."},{"issue":"8","key":"2026090809091864800_cit29","doi-asserted-by":"publisher","first-page":"211","DOI":"10.2166\/wst.1999.0424","article-title":"Excess Sludge\nDischarge Frequency for UASB Reactors","volume":"40","author":"Cavalcanti","year":"1999","journal-title":"Water\nSci. Technol."},{"key":"2026090809091864800_cit30","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.biortech.2013.07.128","article-title":"Effects of Organic Loading Rate and\nEffluent Recirculation on the Performance of Two-Stage Anaerobic Digestion\nof Vegetable Waste","volume":"146","author":"Zuo","year":"2013","journal-title":"Bioresour. Technol."},{"key":"2026090809091864800_cit31","volume-title":"Standard Methods for the Examination of Water\nand Wastewater","author":"APHA.","year":"2005"},{"issue":"5","key":"2026090809091864800_cit32","first-page":"448","article-title":"Measuring Anaerobic Sludge Digestion\nand Growth by a Simple Alkalimetric Titration","volume":"55","author":"Jenkins","year":"1983","journal-title":"Water Pollut. Control Fed"},{"issue":"4","key":"2026090809091864800_cit33","first-page":"356","article-title":"Volatile Acids by Direct Titration","volume":"33","author":"DiLallo","year":"1961","journal-title":"Water Pollut. 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