{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:45:05Z","timestamp":1769042705152,"version":"3.49.0"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"42","license":[{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00490-22"],"award-info":[{"award-number":["APQ-00490-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00544-23"],"award-info":[{"award-number":["APQ-00544-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-01455-24"],"award-info":[{"award-number":["APQ-01455-24"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ02882-24"],"award-info":[{"award-number":["APQ02882-24"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-05218-23"],"award-info":[{"award-number":["APQ-05218-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-05607-24"],"award-info":[{"award-number":["APQ-05607-24"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["RED-00110- 23"],"award-info":[{"award-number":["RED-00110- 23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["30476\/2025-4"],"award-info":[{"award-number":["30476\/2025-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["304916\/2025-0"],"award-info":[{"award-number":["304916\/2025-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["309500\/2025-7"],"award-info":[{"award-number":["309500\/2025-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["405032\/2021-8"],"award-info":[{"award-number":["405032\/2021-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["408115\/2023-8"],"award-info":[{"award-number":["408115\/2023-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["455536\/2014-7"],"award-info":[{"award-number":["455536\/2014-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2025,10,28]]},"DOI":"10.1021\/acsomega.5c06421","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T13:00:23Z","timestamp":1760792423000},"page":"50007-50018","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis and Biological Assessment of New Thiazoles for Mycobacterial Infections and Biofilm Disruption"],"prefix":"10.1021","volume":"10","author":[{"given":"La\u00eds Regina dos Santos","family":"Folquitto","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica","place":["Alfenas, Brazil"]},{"name":"Universidade Federal de Alfenas","place":["Alfenas, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fallon dos Santos","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas","place":["Santa Maria, Brazil"]},{"name":"Universidade Federal de Santa Maria","place":["Santa Maria, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tayn\u00e1 Roberta","family":"Nunes","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica","place":["Alfenas, Brazil"]},{"name":"Universidade Federal de Alfenas","place":["Alfenas, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3627-6407","authenticated-orcid":true,"given":"Thiago Belarmino de","family":"Souza","sequence":"additional","affiliation":[{"name":"Escola de Farm\u00e1cia","place":["Ouro Preto, Brazil"]},{"name":"Universidade Federal de Ouro Preto","place":["Ouro Preto, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6362-2822","authenticated-orcid":true,"given":"Diogo Teixeira","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias Farmac\u00eauticas","place":["Alfenas, Brazil"]},{"name":"Universidade Federal de Alfenas","place":["Alfenas, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Pereira","family":"Machado","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica","place":["Alfenas, Brazil"]},{"name":"Universidade Federal de Alfenas","place":["Alfenas, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Carlos","family":"Doriguetto","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica","place":["Alfenas, Brazil"]},{"name":"Universidade Federal de Alfenas","place":["Alfenas, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marli Matiko Anraku De","family":"Campos","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas","place":["Santa Maria, Brazil"]},{"name":"Universidade Federal de Santa Maria","place":["Santa Maria, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9398-6478","authenticated-orcid":true,"given":"Livia de Figueiredo","family":"Diniz","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas","place":["Alfenas, Brazil"]},{"name":"Universidade Federal de Alfenas","place":["Alfenas, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisi Gomes","family":"Soares","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica","place":["Alfenas, Brazil"]},{"name":"Universidade Federal de Alfenas","place":["Alfenas, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2274-4919","authenticated-orcid":true,"given":"Daniela Aparecida","family":"Chagas de Paula","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica","place":["Alfenas, Brazil"]},{"name":"Universidade Federal de Alfenas","place":["Alfenas, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9129-4734","authenticated-orcid":true,"given":"Danielle Ferreira","family":"Dias","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica","place":["Alfenas, Brazil"]},{"name":"Universidade Federal de Alfenas","place":["Alfenas, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2025,10,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70316-X"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-6285-8.00185-4"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00303"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116236"},{"key":"ref5\/cit5","first-page":"544","volume":"24","author":"Macedo J. L. S.","year":"2009","journal-title":"Braz. J. Plast. Sur."},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127655"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.03.016"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.05.093"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13948"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103496"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.09.086"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13628"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.08.054"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.2174\/1389557523666230726142459"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.2174\/1389557523666230713115947"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.33263\/BRIAC122.21712195"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2025.127064"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.05030-11"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr578"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1994.tb07194.x"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117917"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100066"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.2174\/1573407216999200723114241"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2020.1827399"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2019.04.023"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.21577\/0103-5053.20190038"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA04803C"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2021.112864"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.03.065"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/jf073272v"},{"key":"ref31\/cit31","volume-title":"The chemistry of heterocycles - structure, reactions, syntheses, and applications","author":"Eicher T.","year":"2023","edition":"2"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.12.031"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1039\/C6OB01887D"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1007\/s12039-015-0924-9"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04601-14"},{"key":"ref36\/cit36","volume":"31","author":"CLSI","year":"2021","journal-title":"Clinical and Laboratory Standards Institute. Susceptibility testing of mycobacteria, nocardiae and other aerobic actinomycetes"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.4103\/2212-5531.201894"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2016.08.017"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1080\/08927014.2018.1514497"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02020-14"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.31514\/rliberato.2013v14n22.p213"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms5010009"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukaryotGeneExpr.2014010545"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1339"},{"key":"ref45\/cit45","author":"Bruker","year":"2016","journal-title":"APEX3, SAINT-Plus and SADABS"},{"key":"ref46\/cit46","volume-title":"CrysAlisPro, version 1.171.39.46","year":"2018"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1107\/S2053229614024218"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889808042726"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807067908"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02264-18"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2015.04.002"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c06421","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c06421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T08:52:39Z","timestamp":1761641559000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c06421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,18]]},"references-count":51,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2025,10,28]]}},"alternative-id":["10.1021\/acsomega.5c06421"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c06421","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,18]]}}}