{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:42:12Z","timestamp":1787236932909,"version":"build-2736575974"},"reference-count":72,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"DOI":"10.1021\/acsomega.5c08220","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T02:03:38Z","timestamp":1764209018000},"source":"Crossref","is-referenced-by-count":2,"title":["Metformin-Loaded Fusogenic Liposome Improves the Therapeutic Efficacy and Safety of Doxorubicin in a Breast Cancer Treatment"],"prefix":"10.1021","author":[{"given":"Tha\u00eds Mendes","family":"Pinheiro","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Products, Faculty of Pharmacy","place":["Belo Horizonte, Brazil"]},{"name":"Universidade Federal de Minas Gerais","place":["Belo Horizonte, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00eds Cristina de Amaral","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Products, Faculty of Pharmacy","place":["Belo Horizonte, Brazil"]},{"name":"Universidade Federal de Minas Gerais","place":["Belo Horizonte, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana de Oliveira","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Products, Faculty of Pharmacy","place":["Belo Horizonte, Brazil"]},{"name":"Universidade Federal de Minas Gerais","place":["Belo Horizonte, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia Lobato","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Products, Faculty of Pharmacy","place":["Belo Horizonte, Brazil"]},{"name":"Universidade Federal de Minas Gerais","place":["Belo Horizonte, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geovanni Dantas","family":"Cassali","sequence":"additional","affiliation":[{"name":"Department of General Pathology, Institute of Biological Sciences","place":["Belo Horizonte, Brazil"]},{"name":"Universidade Federal de Minas Gerais","place":["Belo Horizonte, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia Martins","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinic and Surgery, Faculty of Veterinary Medicine","place":["Belo Horizonte, Brazil"]},{"name":"Universidade Federal de Minas Gerais","place":["Belo Horizonte, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marthin Raboch","family":"Lempek","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinic and Surgery, Faculty of Veterinary Medicine","place":["Belo Horizonte, Brazil"]},{"name":"Universidade Federal de Minas Gerais","place":["Belo Horizonte, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel da Silva","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinic and Surgery, Faculty of Veterinary Medicine","place":["Belo Horizonte, Brazil"]},{"name":"Universidade Federal de Minas Gerais","place":["Belo Horizonte, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyelle M.","family":"Townsend","sequence":"additional","affiliation":[{"name":"Department of Drug Discovery and Biomedical Sciences","place":["Charleston, United States"]},{"name":"Medical University of South Carolina","place":["Charleston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8812-3811","authenticated-orcid":true,"given":"Elaine Amaral","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Products, Faculty of Pharmacy","place":["Belo Horizonte, Brazil"]},{"name":"Universidade Federal de Minas Gerais","place":["Belo Horizonte, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7641-6585","authenticated-orcid":true,"given":"Andr\u00e9 Luis","family":"Branco de Barros","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses, Faculty of Pharmacy","place":["Belo Horizonte, Brazil"]},{"name":"Universidade Federal de Minas Gerais","place":["Belo Horizonte, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref1\/cit1","first-page":"451","volume":"10","author":"Chhikara B. S.","year":"2023","journal-title":"Chem. Biol. Lett."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"ref3\/cit3","unstructured":"World Health Organization\n                      Breast\ncancer\n                      ; World Health Organization. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/breast-cancer (acessed 20 October 2024)."},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1999.17.8.2341"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12539"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.045"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.10.04"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196763"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/ph15050626"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1177\/0960327119888277"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1177\/2050312119865114"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.4155\/tde.13.80"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00080"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23773"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.9b00199"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.am2019-3638"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23187"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1978.tb22010.x"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109323"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2018.1548470"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(93)90105-9"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14112394"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15122751"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.4185"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.105205"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2011.09.006"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b01164"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-023-02850-9"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-020-09673-5"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(82)80014-5"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2919"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.01.001"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119019"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2013.1649"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000000505"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2012.011432"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2018.05.037"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.06.017"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b22693"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10020057"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1007\/s40005-018-0398-0"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11110559"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.4155\/bio.10.204"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2014.954582"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115280"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3109\/08982109409037057"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020369"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.05.028"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27041372"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2021.129849"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16020235"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-013-9926-4"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101670"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2013.779332"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.12.019"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-024-03764-2"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2022.05.018"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-07996-2"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.594200"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1063\/1.5126232"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173725"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.11.011"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.10.029"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.12.026"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-20-0115"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c14405"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0425-0"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2021.08.003"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1590\/1981-52712015v40n4e01292015"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1992.tb03156.x"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2019.02.003"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119019"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c08220","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c08220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:14:37Z","timestamp":1765278877000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c08220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":72,"alternative-id":["10.1021\/acsomega.5c08220"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c08220","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"article-number":"acsomega.5c08220"}}