{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:50:25Z","timestamp":1789487425465,"version":"build-2803163510"},"reference-count":76,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018786","name":"Al-Zaytoonah University of Jordan","doi-asserted-by":"publisher","award":["08\/13\/2021-2022"],"award-info":[{"award-number":["08\/13\/2021-2022"]}],"id":[{"id":"10.13039\/501100018786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Green-synthesized zinc oxide nanoparticles (ZnO NPs) can be used to explore their anticancer applications. Therefore, this study aimed to synthesize ZnO NPs using an eco-friendly method by combining Phoenix dactylifera (P. dactylifera) root hair extract with 0.8 M zinc acetate dihydrate at a volume ratio of 4:1. The ZnO NPs had an average size of 24.01 \u00b1 1.70 nm, a polydispersity index (PDI) of 0.25 \u00b1 0.02, and a zeta potential of \u221218.45 \u00b1 1.80 mV. The X-ray diffraction analysis revealed the crystalline structure of ZnO NPs, and the energy-dispersive spectroscopy analysis showed zinc and oxygen compositions of 43.64% and 31.60%, respectively, confirming the formation of green-synthesized ZnO NPs. The ZnO NPs were then incorporated into dissolving microneedles (MNs) prepared using 10% sodium carboxymethyl cellulose (Na CMC). Additionally, doxorubicin hydrochloride (DOX), a chemotherapeutic agent used to treat breast cancer, was also loaded into MNs (DOX-loaded MNs). The ZnO NP- and DOX-loaded MNs were evaluated for morphology, mechanical properties, needle insertion, dissolution rate, recovery of ZnO and DOX, FTIR, ex vivo permeation, and stability. Both types of MNs exhibited a pyramidal shape with a square base, were capable of withstanding a compression force of 32 N for 30 s, pierced the Parafilm M sheet at a depth of 378\u2013504 \u03bcm, and dissolved completely within 30 min. The ZnO NP-loaded MNs remained stable for 2 weeks at room temperature and in the refrigerator. Whereas DOX-loaded MNs remained stable for up to 1 week at room temperature and 2 weeks in the refrigerator. In vitro cytotoxicity studies showed that green-synthesized ZnO NPs reduced the viability of breast cancer cells; however, these studies evaluated free ZnO NPs rather than the MN formulation itself. In conclusion, MNs demonstrated a promising platform for enhancing the transdermal delivery of green-synthesized ZnO NPs and DOX, representing a novel approach combining P. dactylifera-derived ZnO nanoparticles with dissolving microneedle-based delivery.<\/jats:p>","DOI":"10.1021\/acsomega.5c08765","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:30:03Z","timestamp":1788323403000},"page":"53725-53744","source":"Crossref","is-referenced-by-count":0,"title":["Fabrication and\nCharacterization of Green-Synthesized\nZinc Oxide Nanoparticles Loaded into Dissolving Microneedles: A Potential\nDelivery Platform for Breast Cancer Therapy"],"prefix":"10.1021","volume":"11","author":[{"given":"Haneen Faris","family":"Al-Shawabkeh","sequence":"first","affiliation":[{"name":"Al-Zaytoonah University of Jordan , , ,","place":["Amman, Jordan, 11733"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa","family":"Aburayya","sequence":"additional","affiliation":[{"name":"Al-Zaytoonah University of Jordan , , ,","place":["Amman, Jordan, 11733"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haneen A.","family":"Basheer","sequence":"additional","affiliation":[{"name":"Zarqa University , , ,","place":["Zarqa, Jordan, 13110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9646-6328","authenticated-orcid":true,"given":"Ahlam","family":"Zaid Alkilani","sequence":"additional","affiliation":[{"name":"Zarqa University , , ,","place":["Zarqa, Jordan, 13110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maram A.","family":"Alhusban","sequence":"additional","affiliation":[{"name":"Zarqa University , , ,","place":["Zarqa, Jordan, 13110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7132-801X","authenticated-orcid":true,"given":"Rania","family":"Hamed","sequence":"additional","affiliation":[{"name":"Al-Zaytoonah University of Jordan , , ,","place":["Amman, Jordan, 11733"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"issue":"17","key":"2026091510093660300_cit1","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.3390\/cancers13174287","article-title":"Breast cancer\u2500epidemiology, risk factors, classification,\nprognostic markers, and current treatment strategies\u2500an updated\nreview","volume":"13","author":"\u0141ukasiewicz","year":"2021","journal-title":"Cancers"},{"issue":"11","key":"2026091510093660300_cit2","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.17219\/acem\/156058","article-title":"Novel electroporation-based\ntreatments for breast cancer","volume":"31","author":"\u0141apin\u0301ska","year":"2022","journal-title":"Adv. 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