{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:42:17Z","timestamp":1785940937736,"version":"3.56.0"},"reference-count":54,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2013\/07600-3"],"award-info":[{"award-number":["2013\/07600-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2020\/13962-9"],"award-info":[{"award-number":["2020\/13962-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2022\/00600-7"],"award-info":[{"award-number":["2022\/00600-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2022\/05327-7"],"award-info":[{"award-number":["2022\/05327-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2022\/06051-5"],"award-info":[{"award-number":["2022\/06051-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2022\/08837-6"],"award-info":[{"award-number":["2022\/08837-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2024\/01273-5"],"award-info":[{"award-number":["2024\/01273-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2026,2,10]]},"DOI":"10.1021\/acsomega.5c08888","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T21:35:25Z","timestamp":1769722525000},"page":"7616-7626","source":"Crossref","is-referenced-by-count":1,"title":["Transition-Metal-Free One-Pot Synthesis of (Hetero)chalcones with Cysteine Protease Inhibitory Activity"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6998-0762","authenticated-orcid":true,"given":"Thais Rodrigues","family":"Arroio","sequence":"first","affiliation":[{"name":"Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. do Caf\u00e9 s\/n, Ribeir\u00e3o Preto, Sao Paulo 14040-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco Jazon","family":"Caires","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. do Caf\u00e9 s\/n, Ribeir\u00e3o Preto, Sao Paulo 14040-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela de Oliveira","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. do Caf\u00e9 s\/n, Ribeir\u00e3o Preto, Sao Paulo 14040-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8423-9454","authenticated-orcid":true,"given":"Victor Hugo Catricala","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. do Caf\u00e9 s\/n, Ribeir\u00e3o Preto, Sao Paulo 14040-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Wada Ferreira","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. do Caf\u00e9 s\/n, Ribeir\u00e3o Preto, Sao Paulo 14040-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edz Vin\u00edcius Santos de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. do Caf\u00e9 s\/n, Ribeir\u00e3o Preto, Sao Paulo 14040-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Cezar","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. do Caf\u00e9 s\/n, Ribeir\u00e3o Preto, Sao Paulo 14040-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7605-4150","authenticated-orcid":true,"given":"Giuliano Cesar","family":"Clososki","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Av. do Caf\u00e9 s\/n, Ribeir\u00e3o Preto, Sao Paulo 14040-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00020"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-014-9387-8"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1039\/D0NP00083C"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1570385"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.2174\/0929867053363153"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2007.12.027"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-01292-5"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.2174\/0929867330666230220140819"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.03.033"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3390\/biom11060894"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111306"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA03684F"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO01298B"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.21577\/0103-5053.20200013"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201900350"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127173"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-021-02742-5"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666181001112226"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2022.2120396"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1007\/s41061-024-00468-7"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22081210"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-011-9900-1"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26052025"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104681"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24234309"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071679"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020476"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006512"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009013"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202001737"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28227576"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2010.09.089"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1039\/b912099h"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.201900297"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b02818"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b00594"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC08926H"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1134\/S0012500810050046"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC05122B"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC03996D"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1039\/C5DT00575B"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA04985H"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/ja01100a508"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1080\/00397910903291129"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201702400"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.11.003"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2017.08.017"},{"key":"ref48\/cit48","unstructured":"E-64. Selleck Chemicals\n                      . https:\/\/www.selleckchem.com\/products\/e-64.html (accessed July 2025)."},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093161"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63749-9.00006-2"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-018-2449-y"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/ci800085c"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/bi00014a037"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1007\/s42770-020-00256-7"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c08888","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c08888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:23:56Z","timestamp":1770719036000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c08888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,2,10]]}},"alternative-id":["10.1021\/acsomega.5c08888"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c08888","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]}}}