{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:35:06Z","timestamp":1790314506035,"version":"4.1.0"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["305176\/2025-0"],"award-info":[{"award-number":["305176\/2025-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda??o Carlos Chagas Filho de Amparo ? Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/210.018\/2020"],"award-info":[{"award-number":["E-26\/210.018\/2020"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda??o Carlos Chagas Filho de Amparo ? Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/210.699\/2024"],"award-info":[{"award-number":["E-26\/210.699\/2024"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2026,3,3]]},"DOI":"10.1021\/acsomega.5c09002","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:18:41Z","timestamp":1771341521000},"page":"13184-13198","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis and Pharmacological Evaluation of Novel 1,5-Disubstituted-3-amino-1,2,4-triazoles Designed as Multitarget Directed Ligands for Alzheimer\u2019s Disease Targets"],"prefix":"10.1021","volume":"11","author":[{"given":"Daiana Portella","family":"Franco","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry","place":["Serop\u00e9dica, Brazil"]},{"name":"Federal Rural University of Rio de Janeiro","place":["Serop\u00e9dica, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Caruso","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry","place":["Serop\u00e9dica, Brazil"]},{"name":"Federal Rural University of Rio de Janeiro","place":["Serop\u00e9dica, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danniel Cosme Neves","family":"Grillo","sequence":"additional","affiliation":[{"name":"Laboratory of Oxidative Stress in Microorganisms, Department of Biochemistry, Institute of Chemistry","place":["Serop\u00e9dica, Brazil"]},{"name":"Federal Rural University of Rio de Janeiro","place":["Serop\u00e9dica, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nath\u00e1lia Fonseca","family":"Nadur","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry","place":["Serop\u00e9dica, Brazil"]},{"name":"Federal Rural University of Rio de Janeiro","place":["Serop\u00e9dica, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Luiz","family":"de Azevedo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry","place":["Serop\u00e9dica, Brazil"]},{"name":"Federal Rural University of Rio de Janeiro","place":["Serop\u00e9dica, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Moreira","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry","place":["Serop\u00e9dica, Brazil"]},{"name":"Federal Rural University of Rio de Janeiro","place":["Serop\u00e9dica, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuelle Cunha","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry","place":["Serop\u00e9dica, Brazil"]},{"name":"Federal Rural University of Rio de Janeiro","place":["Serop\u00e9dica, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Barbosa","family":"Lacerda","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry","place":["Serop\u00e9dica, Brazil"]},{"name":"Federal Rural University of Rio de Janeiro","place":["Serop\u00e9dica, Brazil"]},{"name":"Department of Pharmaceutical Sciences, Institute of Biological and Health Sciences","place":["Serop\u00e9dica, Brazil"]},{"name":"Federal Rural University of Rio de Janeiro","place":["Serop\u00e9dica, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4148-4243","authenticated-orcid":true,"given":"Pedro de Sena Murteira","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Avalia\u00e7\u00e3o e S\u00edntese de Subst\u00e2ncias Bioativas (LASSBio), Instituto de Ci\u00eancias Biom\u00e9dicas","place":["Rio de Janeiro, Brazil"]},{"name":"Universidade Federal do Rio de Janeiro","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano Jorge","family":"Riger","sequence":"additional","affiliation":[{"name":"Laboratory of Oxidative Stress in Microorganisms, Department of Biochemistry, Institute of Chemistry","place":["Serop\u00e9dica, Brazil"]},{"name":"Federal Rural University of Rio de Janeiro","place":["Serop\u00e9dica, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8458-0975","authenticated-orcid":true,"given":"Arthur Eugen","family":"K\u00fcmmerle","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Diversity and Medicinal Chemistry (LaDMol-QM), Department of Organic Chemistry, Institute of Chemistry","place":["Serop\u00e9dica, Brazil"]},{"name":"Federal Rural University of Rio de Janeiro","place":["Serop\u00e9dica, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.742408"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112193"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201800050"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.5935\/0100-4042.20150152"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12802"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy132"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2000.2.2\/lschneider"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.21577\/1984-6835.20200133"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/biom10010040"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.01.044"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1177\/24725552211030897"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112257"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113973"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111916"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.07.033"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00048"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.2174\/1385272825666211011111408"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.134487"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA04105B"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8899-y"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(00)80547-8"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2019.1571270"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/jm9013828"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2012.05.004"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/ph18091398"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.43.30370"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.106301"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.106301"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.117030"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X18666200122122512"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1111\/1567-1364.12091"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-140-3-569"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-017-2709-2"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1039\/C6NJ01532H"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2025.113389"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c09002","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c09002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:12:40Z","timestamp":1773133960000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c09002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,17]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,3,3]]}},"alternative-id":["10.1021\/acsomega.5c09002"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c09002","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,17]]}}}