{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:27:03Z","timestamp":1790310423381,"version":"4.1.0"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2024\/2704"],"award-info":[{"award-number":["2024\/2704"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023\/09402-6"],"award-info":[{"award-number":["2023\/09402-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023\/14753-2"],"award-info":[{"award-number":["2023\/14753-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bacterial contamination and low osteogenic activity are the major causes of dental implant failure. The development of titanium coatings has provided new research directions to improve both antibacterial and osteogenic activity. In this study, we constructed phospholipidic films containing carbonate hydroxyapatite added or not to silver nanoparticles. The purpose was to reduce the biofilm formation while maintaining the osteogenic potential of surfaces. Phospholipid monolayers were transferred to titanium by Langmuir\u2013Blodgett (LB) technique and resulted in dense, ordered and uniform films. Modified surfaces were evaluated by X-ray photoelectron spectroscopy, energy-dispersive spectroscopy, Fourier-transform infrared spectroscopy, and atomic force microscopy to confirm that films were successfully coated onto the titanium substrate. In addition, surface free energy and roughness analyses indicated that surfaces were smooth and hydrophilic. ICP-OES analysis confirmed the absence of silver nanoparticle lixiviation from the coatings. Furthermore, the coatings had great biocompatibility and promoted the proliferation of osteoblast-like cells. Microbiological findings showed that biofilm formation and bacterial adhesion were significantly reduced for the experimental coatings; species closely related to peri-implant diseases and associated with increased biofilm volume were shown reduced. Addition of silver nanoparticles did not improve biofilm control. In conclusion, the phospholipidic films proposed to modify the titanium surfaces are beneficial for osseointegration and can act as a promising method to reduce the biofilm formation and bacterial colonization for dental implants.<\/jats:p>","DOI":"10.1021\/acsomega.5c09762","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T05:23:48Z","timestamp":1772083428000},"page":"14479-14500","source":"Crossref","is-referenced-by-count":3,"title":["Antibacterial and\nAntibiofilm Activity of Titanium\nTreated with Hybrid Phospholipid Films Containing Carbonate Hydroxyapatite\nand Silver Nanoparticles"],"prefix":"10.1021","volume":"11","author":[{"given":"Carla\nRoberta de Oliveira","family":"Maciel","sequence":"first","affiliation":[{"name":"Ribeira\u0303o Preto School of Dentistry, Sa\u0303o Paulo University (USP) , Dental Materials and Prosthodontics, Ribeira\u0303o Preto , , ,","place":["Sa\u0303o Paulo, Brazil, 14040-904"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailton Cravo","family":"Moraes Filho","sequence":"additional","affiliation":[{"name":"Ribeira\u0303o Preto School of Dentistry, Sa\u0303o Paulo University (USP) , Dental Materials and Prosthodontics, Ribeira\u0303o Preto , , ,","place":["Sa\u0303o Paulo, Brazil, 14040-904"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonieta Catalina","family":"Varela Garcia","sequence":"additional","affiliation":[{"name":"Ribeira\u0303o Preto School of Dentistry, Sa\u0303o Paulo University (USP) , Dental Materials and Prosthodontics, Ribeira\u0303o Preto , , ,","place":["Sa\u0303o Paulo, Brazil, 14040-904"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0734-0652","authenticated-orcid":true,"given":"Viviane de Ca\u0301ssia","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Ribeira\u0303o Preto School of Dentistry, Sa\u0303o Paulo University (USP) , Dental Materials and Prosthodontics, Ribeira\u0303o Preto , , ,","place":["Sa\u0303o Paulo, Brazil, 14040-904"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6200-8989","authenticated-orcid":true,"given":"Ana Paula","family":"Ramos","sequence":"additional","affiliation":[{"name":"University of Sao Paulo , , Bandeirantes, 3900, Ribeirao Preto , , ,","place":["Sa\u0303o Paulo, Brazil, 14040-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Faria","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Ribeira\u0303o Preto School of Dentistry, Sa\u0303o Paulo University (USP) , Dental Materials and Prosthodontics, Ribeira\u0303o Preto , , ,","place":["Sa\u0303o Paulo, Brazil, 14040-904"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelle Beathriz\nFernandes","family":"da Silva","sequence":"additional","affiliation":[{"name":"Bone Research Lab, Ribeira\u0303o Preto School of Dentistry, University of Sa\u0303o Paulo, Ribeira\u0303o Preto , , ,","place":["Sa\u0303o Paulo, Brazil, 14040-904"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2492-3324","authenticated-orcid":true,"given":"Rafael Soares","family":"Stenico","sequence":"additional","affiliation":[{"name":"University of Sao Paulo , , Bandeirantes, 3900, Ribeirao Preto , , ,","place":["Sa\u0303o Paulo, Brazil, 14040-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Andreia\nMesquita Silva","family":"da Veiga","sequence":"additional","affiliation":[{"name":"University of Sao Paulo , , Bandeirantes, 3900, Ribeirao Preto , , ,","place":["Sa\u0303o Paulo, Brazil, 14040-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2220-0148","authenticated-orcid":true,"given":"Ca\u0301ssio","family":"do Nascimento","sequence":"additional","affiliation":[{"name":"Ribeira\u0303o Preto School of Dentistry, Sa\u0303o Paulo University (USP) , Dental Materials and Prosthodontics, Ribeira\u0303o Preto , , ,","place":["Sa\u0303o Paulo, Brazil, 14040-904"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"issue":"13","key":"2026081508074614300_cit1","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1177\/0022034518792567","article-title":"Trends in Dental\nImplant Use in the U.S., 1999\u20132016, and Projections to 2026","volume":"97","author":"Elani","year":"2018","journal-title":"J. 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Surf. Sci."},{"key":"2026081508074614300_cit35","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/B978-0-12-803581-8.10171-7","article-title":"Bioactive calcium\nphosphate compounds: Physical chemistry","volume-title":"Comprehensive\nBiomaterials II","author":"Rey","year":"2017"},{"issue":"18","key":"2026081508074614300_cit36","doi-asserted-by":"publisher","first-page":"4127","DOI":"10.1016\/j.biomaterials.2003.11.030","article-title":"Bone-like\napatite layer formation\non hydroxyapatite prepared by spark plasma sintering (SPS)","volume":"25","author":"Gu","year":"2004","journal-title":"Biomaterials"},{"issue":"7","key":"2026081508074614300_cit37","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1002\/jbm.b.34069","article-title":"Different compact hybrid Langmuir\u2013Blodgett-film\ncoatings modify biomineralization and the ability of osteoblasts to\ngrow","volume":"106","author":"de\nFaria","year":"2018","journal-title":"J. Biomed Mater. Res. B Appl. 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A Physicochem Eng. Asp."},{"key":"2026081508074614300_cit42","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.surfcoat.2023.130036","article-title":"Comparative\nstudy of calcium phosphate deposition on nanotubular and sandblasted\nlarge grit acid-etched titanium substrates","volume":"25","author":"dos\nR. Weitzel","year":"2023","journal-title":"Surf. Coat. Technol."},{"key":"2026081508074614300_cit43","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.surfcoat.2023.130036","article-title":"Comparative\nstudy of calcium phosphate deposition on nanotubular and sandblasted\nlarge grit acid-etched titanium substrates","volume":"25","author":"dos\nR. Weitzel","year":"2023","journal-title":"Surf. Coat. Technol."},{"issue":"18","key":"2026081508074614300_cit44","doi-asserted-by":"publisher","first-page":"10562","DOI":"10.1021\/acsomega.0c00986","article-title":"Poly-l-lysine\/Sodium Alginate Coating Loading Nanosilver for Improving\nthe Antibacterial Effect and Inducing Mineralization of Dental Implants","volume":"5","author":"Guo","year":"2020","journal-title":"ACS Omega"},{"key":"2026081508074614300_cit45","doi-asserted-by":"publisher","first-page":"111863","DOI":"10.1016\/j.msec.2021.111863","article-title":"Polymeric antibiofilm coating comprising\nsynergistic\ncombination of citral and thymol prevents methicillin-resistant Staphylococcus\naureus biofilm formation on titanium","volume":"121","author":"Valliammai","year":"2021","journal-title":"Mater.\nSci. Eng. C Mater. Biol. 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