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This work extends the solubility database of four polyphenols (trans-polydatin, p-coumaric acid, quercetin, and trans-resveratrol) by determining and modeling their equilibrium solubility in methanol, ethanol, and ethyl acetate at 298.2 K and 0.1 MPa. Additionally, solubility in two binary mixtures (methanol + ethyl acetate and ethanol + ethyl acetate) was measured to assess the ester cosolvent effect. Excess solubility was calculated to evaluate nonideality, and experimental data were correlated using the Abraham solvation model, the CNIBS\/R\u2013K equation, and solvatochromic (KAT) parameters. Higher solubility was observed in ethanol than methanol for all compounds except for trans-polydatin, while ethyl acetate showed the lowest values. All ternary systems exhibited solubility maxima due to synergistic effect of ethyl acetate, being the greatest solubility enhancement observed for trans-resveratrol, with a 129% increase at 0.4 mole fraction of the ester solvent in the methanol + ethyl acetate binary solvent mixture. Eventually, all systems were accurately described by the Abraham model, CNIBS\/R-K equation, and KAT parameters.<\/jats:p>","DOI":"10.1021\/acsomega.5c10953","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:43:17Z","timestamp":1772109797000},"page":"14774-14786","source":"Crossref","is-referenced-by-count":1,"title":["Experimental and\nModeling Assessment of Polyphenol\nSolubility in Alcohol + Ethyl Acetate Mixtures for Extraction Applications"],"prefix":"10.1021","volume":"11","author":[{"given":"Iva\u0301n","family":"Montenegro","sequence":"first","affiliation":[{"name":"University of Vigo , , ,","place":["Vigo, Spain, 36310"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3380-2494","authenticated-orcid":true,"given":"Begon\u0303a","family":"Gonza\u0301lez","sequence":"additional","affiliation":[{"name":"University of Vigo , , ,","place":["Vigo, Spain, 36310"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6695-4064","authenticated-orcid":true,"given":"A\u0301ngeles","family":"Domi\u0301nguez","sequence":"additional","affiliation":[{"name":"University of Vigo , , ,","place":["Vigo, Spain, 36310"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3324-4733","authenticated-orcid":true,"given":"Elena","family":"Go\u0301mez","sequence":"additional","affiliation":[{"name":"University of Vigo , , ,","place":["Vigo, Spain, 36310"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"2026081508072579000_cit1","doi-asserted-by":"publisher","first-page":"100749","DOI":"10.1016\/j.focha.2024.100749","article-title":"A review on the influence\nof nutraceuticals and functional foods on health","volume":"5","author":"Vignesh","year":"2024","journal-title":"Food Chem. 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