{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:02:56Z","timestamp":1787000576784,"version":"build-2736575974"},"reference-count":68,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda????o de Amparo ?? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-01683-23"],"award-info":[{"award-number":["APQ-01683-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda????o de Amparo ?? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-02928-25"],"award-info":[{"award-number":["APQ-02928-25"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2026,3,24]]},"DOI":"10.1021\/acsomega.5c11099","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:02:11Z","timestamp":1773136931000},"page":"17530-17542","source":"Crossref","is-referenced-by-count":1,"title":["Spermidine Supplementation Reduces Genetic Damage in the Liver and Bone Marrow of Rodents"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8599-1097","authenticated-orcid":true,"given":"Janine","family":"Barcelos Chacon","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Nutri\u00e7\u00e3o e Longevidade, Universidade Federal de Alfenas Alfenas, UNIFAL, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais 37130-001, Brasil"},{"name":"Laborat\u00f3rio de Gen\u00e9tica Humana, Instituto de Ci\u00eancias da Natureza, Universidade Federal de Alfenas\u2500UNIFAL, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais 37130-001, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Clara","family":"Duarte","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Humana, Instituto de Ci\u00eancias da Natureza, Universidade Federal de Alfenas\u2500UNIFAL, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais 37130-001, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele Oliveira","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Humana, Instituto de Ci\u00eancias da Natureza, Universidade Federal de Alfenas\u2500UNIFAL, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais 37130-001, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Felix","family":"\u00c1vila","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Nutri\u00e7\u00e3o e Longevidade, Universidade Federal de Alfenas Alfenas, UNIFAL, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais 37130-001, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Caroline","family":"Menon","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Humana, Instituto de Ci\u00eancias da Natureza, Universidade Federal de Alfenas\u2500UNIFAL, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais 37130-001, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"de Mello Franco","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Humana, Instituto de Ci\u00eancias da Natureza, Universidade Federal de Alfenas\u2500UNIFAL, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais 37130-001, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5022-4796","authenticated-orcid":true,"given":"Bruno Martins","family":"Dala Paula","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Nutri\u00e7\u00e3o e Longevidade, Universidade Federal de Alfenas Alfenas, UNIFAL, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais 37130-001, Brasil"},{"name":"Laborat\u00f3rio de Nutri\u00e7\u00e3o Experimental, Faculdade de Nutri\u00e7\u00e3o, Universidade Federal de Alfenas\u2500UNIFAL, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais 37130-001, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-0277","authenticated-orcid":true,"given":"Pollyanna Francielli de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Nutri\u00e7\u00e3o e Longevidade, Universidade Federal de Alfenas Alfenas, UNIFAL, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais 37130-001, Brasil"},{"name":"Laborat\u00f3rio de Gen\u00e9tica Humana, Instituto de Ci\u00eancias da Natureza, Universidade Federal de Alfenas\u2500UNIFAL, Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, Minas Gerais 37130-001, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1080\/09637486.2016.1191444"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/biom12091228"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4054-0"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ircmb.2021.04.001"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104943"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105974"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1515\/biol-2021-0006"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/biom13050803"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c02729"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.0c07095"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-020-00310-0"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/bios14090427"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-00890-w"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/nu14204318"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.08.027"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.115055"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2023.113666"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.17582\/journal.aavs\/2024\/12.8.1509.1516"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/em.2860020408"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.04.002"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(75)90058-8"},{"key":"ref22\/cit22","volume-title":"Test No. 474: Mammalian Erythrocyte Micronucleus Test; OECD Guidelines for the Testing of Chemicals, Section 4","author":"Organisation for Economic Co-operation and Development","year":"2016"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/18.1.45"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1098-2280(2000)35:3<206::aid-em8>3.0.co;2-j"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1974.tb03714.x"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(84)05016-3"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2004.03.002"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10061248"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/287153"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26040988"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/foods12040753"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/plants12203533"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010142"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.897105"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2006.10.015"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-023-01265-w"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.608047"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-022-02980-2"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12101332"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxy272"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0310-7"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1590\/S1415-52732012000300003"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109842"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.02.021"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2017.06.001"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-67202013000600005"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051317"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2009.02.016"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101354"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2016.272"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113700"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.11.005"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4148"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20051254"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5637-0_26"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-019-02733-2"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010164"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064357"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147461"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2022.109184"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2023.09.005"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.3390\/nu15030744"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-023-03562-9"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14706"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1009415"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2009.00505.x"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90587-M"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c11099","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c11099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:43:15Z","timestamp":1774341795000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c11099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":68,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,3,24]]}},"alternative-id":["10.1021\/acsomega.5c11099"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c11099","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]}}}