{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:01:16Z","timestamp":1791046876007,"version":"4.1.0"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Arastirma Kurumu","doi-asserted-by":"publisher","award":["222Z243"],"award-info":[{"award-number":["222Z243"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This manuscript describes the synthesis of ibuprofen-derived amides, and their biological evaluation with respect to anti-inflammatory and antimicrobial properties, including inhibition of biofilm formation. The compounds were synthesized using a previously developed photoredox-catalyzed protocol, which proceeds through C\u2013N bond scission of the tertiary amine building blocks, followed by in situ amide coupling; thus, 16 derivatives of ibuprofen were prepared on 30 to 70 mg scales. Evaluation in multiple antimicrobial and biofilm-related biological assays revealed desired activities for many of the compounds. Compounds 9\u201311 and 14\u201316 are newly synthesized in the literature, compounds 1\u20138 have been previously reported by us, and compounds 12\u201313 are known in the literature. The broad-spectrum antimicrobial activities of all molecules were evaluated for the first time in these studies. An initial phenotypic screening under inflammatory stress was performed using an MTT-based LPS challenge model, which revealed that several derivatives (2, 4, 7, and 11\u201316) preserved cell viability more effectively than ibuprofen. Based on these findings, selected compounds were further evaluated using direct biochemical assays, demonstrating that ibuprofen amide derivatives significantly suppressed LPS-induced production of the pro-inflammatory cytokines IL-1\u03b2, TNF-\u03b1, and IL-6 in RAW 264.7 macrophages. Assessment of antimicrobial activity against Escherichia coli, MRSA, and Candida albicans demonstrated notable inhibitory activities by compounds 15 and 16. The same compounds also showed inhibition of biofilm growth. Collectively, these results demonstrate that photoredox-catalyzed modification of the ibuprofen scaffold enables rapid access to newly synthesized analogues combining confirmed anti-inflammatory activity with antimicrobial and antibiofilm properties.<\/jats:p>","DOI":"10.1021\/acsomega.5c11131","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T19:23:36Z","timestamp":1772047416000},"page":"14860-14868","source":"Crossref","is-referenced-by-count":1,"title":["Anti-inflammatory\nand Antimicrobial Properties of\nIbuprofen Analogues Derived by Photoredox-Catalyzed C\u2013N Scission\nof Tertiary Amines and Amidation"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9278-1091","authenticated-orcid":true,"given":"Ozgur","family":"YILMAZ","sequence":"first","affiliation":[{"name":"Mersin University , , ,","place":["Mersin, Turkey, 33343"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"DOGAN","sequence":"additional","affiliation":[{"name":"Mersin University , , ,","place":["Mersin, Turkey, 33343"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"YETKIN","sequence":"additional","affiliation":[{"name":"Mersin University , , ,","place":["Mersin, Turkey, 33343"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinar","family":"KUCE CEVIK","sequence":"additional","affiliation":[{"name":"Harran University , , ,","place":["Sanliurfa, Turkey, 63290"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4375-8295","authenticated-orcid":true,"given":"Marion H.","family":"Emmert","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc. , , 770 Sumneytown Pike , , ,","place":["West Point, Pennsylvania, United States, 19486"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"issue":"12","key":"2026081508094388700_cit1","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1002\/jps.2600561238","article-title":"Some Biological\nProperties of 2-(4-Isobutylphenyl)-Propionic Acid","volume":"56","author":"Adams","year":"1967","journal-title":"J. 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Biodiversity"},{"issue":"2","key":"2026081508094388700_cit35","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00706-024-03281-6","article-title":"Synthesis\nof Thioamides from Schiff Bases and Investigation of Their Biological\nActivities","volume":"156","author":"Hilani","year":"2025","journal-title":"Monatshefte fu\u0308r Chemie -\nChem. Mon."},{"issue":"1","key":"2026081508094388700_cit36","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1472-6882-11-29","article-title":"Antibacterial Activity of Thymoquinone, an Active Principle\nof Nigella Sativa and Its Potency to Prevent Bacterial Biofilm Formation","volume":"11","author":"Chaieb","year":"2011","journal-title":"BMC Complementary Altern. 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