{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T05:57:33Z","timestamp":1770789453663,"version":"3.50.0"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013209","name":"Hellenic Foundation for Research and Innovation","doi-asserted-by":"publisher","award":["MIS5002691"],"award-info":[{"award-number":["MIS5002691"]}],"id":[{"id":"10.13039\/501100013209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013209","name":"Hellenic Foundation for Research and Innovation","doi-asserted-by":"publisher","award":["MIS5028091"],"award-info":[{"award-number":["MIS5028091"]}],"id":[{"id":"10.13039\/501100013209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2026,2,10]]},"DOI":"10.1021\/acsomega.5c11378","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T13:59:03Z","timestamp":1769263143000},"page":"8479-8495","source":"Crossref","is-referenced-by-count":0,"title":["Optimization of Pyrazolo[3,4-\n                    <i>b<\/i>\n                    ]pyridine Analogues: Synthesis, In Vitro Anticancer Evaluation and In Vivo Pharmacokinetics"],"prefix":"10.1021","volume":"11","author":[{"given":"Maria","family":"Georgiou","sequence":"first","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Saxonis","sequence":"additional","affiliation":[{"name":"Center for Clinical, Experimental Surgery and Translational Research, Pharmacology-Pharmacotechnology, Biomedical Research Foundation","place":["Athens, Greece"]},{"name":"Academy of Athens","place":["Athens, Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Palaiologou","sequence":"additional","affiliation":[{"name":"Center for Clinical, Experimental Surgery and Translational Research, Pharmacology-Pharmacotechnology, Biomedical Research Foundation","place":["Athens, Greece"]},{"name":"Academy of Athens","place":["Athens, Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Lampropoulou","sequence":"additional","affiliation":[{"name":"Center for Clinical, Experimental Surgery and Translational Research, Pharmacology-Pharmacotechnology, Biomedical Research Foundation","place":["Athens, Greece"]},{"name":"Academy of Athens","place":["Athens, Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5161-7850","authenticated-orcid":true,"given":"Athanasios K.","family":"Anagnostopoulos","sequence":"additional","affiliation":[{"name":"Centre of Systems Biology, Department of Biotechnology, Biomedical Research Foundation","place":["Athens, Greece"]},{"name":"Academy of Athens","place":["Athens, Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Pouli","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Marakos","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0582-4415","authenticated-orcid":true,"given":"Nikolaos","family":"Lougiakis","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, 15771 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9627-4812","authenticated-orcid":true,"given":"Constantin","family":"Tamvakopoulos","sequence":"additional","affiliation":[{"name":"Center for Clinical, Experimental Surgery and Translational Research, Pharmacology-Pharmacotechnology, Biomedical Research Foundation","place":["Athens, Greece"]},{"name":"Academy of Athens","place":["Athens, Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/nu16060800"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.43198"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3033279"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.05.58"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2022.02.007"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.5455\/2319-2003.ijbcp000812"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-018-9903-0"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.10.002"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.2174\/1385272822666181008142138"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3390\/ph16020299"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-024-10870-4"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA02893K"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.134308"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.2174\/0115680266290152240110074034"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2023-0207"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202400470"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202200154"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.14098"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.09.056"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.12.025"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.2174\/1573406415666190222130225"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27010247"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115804"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15030787"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1142\/S1088424623500256"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00923"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.03.037"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1139\/v88-074"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201700340"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.03.019"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27072237"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115985"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2021.128226"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114714"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115543"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1039\/D2MD00334A"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107256"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.108681"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.70056"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.2147\/BCTT.S489246"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-2971"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/srep43047"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.4c00452"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-3-662-04383-7_2","volume-title":"Pharmacokinetic Challenges in Drug Discovery. Ernst Schering Research Foundation Workshop","volume":"37","author":"Lin J. H.","year":"2002"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.6b00961"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c11378","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c11378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:23:18Z","timestamp":1770718998000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c11378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,24]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,2,10]]}},"alternative-id":["10.1021\/acsomega.5c11378"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c11378","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,24]]}}}