{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T14:28:30Z","timestamp":1786804110509,"version":"build-2736575974"},"reference-count":88,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["101081776"],"award-info":[{"award-number":["101081776"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The tomato processing industry is one of the most widespread food manufacturing sectors globally, generating substantial amounts of residue, including tomato skins, peels, seeds, and vascular tissues. These residues still retain valuable bioactive compounds (e.g., carotenoids like lycopene), essential for food, pharmaceutical, and nutraceutical applications. Currently, traditional solvent extraction is the most common method for retrieving these compounds from tomato residue. However, this approach has notable disadvantages, including high solvent consumption and difficulties in utilizing leftover biomass. To address these issues, innovative technologies have introduced modifications to process configurations and techniques that alter or break down plant cells, significantly improving compound recovery. Supercritical fluid extraction offers an effective method for enhancing the value of tomato residues before disposal, as it is an environmentally friendly approach, particularly when carbon dioxide is used as the extraction solvent. The novelty of the present work is the specific optimization and integration of this green extraction technique with the subsequent conjugation of the extracted lycopene to TiO2 nanoparticles (TiO2NPs). This is the first report demonstrating the conjugation of supercritical CO2-extracted lycopene with TiO2NPs, effectively eliminating the use of organic-solvent-derived carotenoids traditionally used in such conjugates. The supercritical CO2-extraction (scCO2) was employed at various times (2, 3, and 4 h), temperatures (40\u201380 \u00b0C), and pressures (25, 30, and 35 MPa). Among the tested protocols, the treatment of tomato at 50 \u00b0C and 30 MPa for 2 h showed the highest yield based on the UV\u2013vis and HPLC results. For the potential pharmaceutical benefits of these extracts, lycopene was directly conjugated with TiO2NPs, using a mild and green approach (TiO2NPs-lycopene) and characterized using different techniques, including HPLC, UV\u2013vis, FTIR-ATR, FESEM-EDS, and DLS to assess the successful loading of 95.0 \u00b1 2.1% of lycopene on the TiO2NPs. The FESEM results exhibited the grain-like TiO2NPs-lycopene particles with a 60\u201380 nm size distribution, indicating size-controlling effect of the lycopene on the TiO2NPs during the conjugation process and the presence of the organic molecule layer on the surface. TiO2NPs-lycopene represents a promising candidate for antimicrobial studies due to the potential synergic effect of TiO2NPs and lycopene in a single nanoplatform. The results show the importance of scCO2-based techniques, as valid alternatives to the conventional methods that exploit organic solvents, to prepare the TiO2NPs-carotenoids conjugates. To the best of our knowledge, this is the first study to report the conjugation of TiO2NPs with lycopene, offering a novel approach to enhance their antioxidant and photoprotective properties.<\/jats:p>","DOI":"10.1021\/acsomega.5c11461","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T12:20:12Z","timestamp":1771849212000},"page":"14919-14928","source":"Crossref","is-referenced-by-count":1,"title":["Extraction of Lycopene\nfrom Tomato Peels Using Supercritical\nCarbon Dioxide and Conjugation of the Extracted Lycopene with TiO2 Nanoparticles"],"prefix":"10.1021","volume":"11","author":[{"given":"Farid\nHajareh","family":"Haghighi","sequence":"first","affiliation":[{"name":"Sapienza University of Rome , , Piazzale Aldo Moro 5 , ,","place":["Rome, Italy, 00185"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roya","family":"Binaymotlagh","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome , , Piazzale Aldo Moro 5 , ,","place":["Rome, Italy, 00185"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Nguemna Tayou","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome , , Piazzale Aldo Moro 5 , ,","place":["Rome, Italy, 00185"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4517-1148","authenticated-orcid":true,"given":"Marianna","family":"Villano","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome , , Piazzale Aldo Moro 5 , ,","place":["Rome, Italy, 00185"]},{"name":"Sapienza University of Rome , , Piazzale Aldo Moro 5 , ,","place":["Rome, Italy, 00185"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Chronopoulou","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome , , Piazzale Aldo Moro 5 , ,","place":["Rome, Italy, 00185"]},{"name":"Sapienza University of Rome , , Piazzale Aldo Moro 5 , ,","place":["Rome, Italy, 00185"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5583-8941","authenticated-orcid":true,"given":"Cleofe","family":"Palocci","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome , , Piazzale Aldo Moro 5 , ,","place":["Rome, Italy, 00185"]},{"name":"Sapienza University of Rome , , Piazzale Aldo Moro 5 , ,","place":["Rome, Italy, 00185"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"2026081508095760100_cit1","doi-asserted-by":"publisher","first-page":"1516048","DOI":"10.3389\/fnut.2025.1516048","article-title":"Dietary Intake of Tomato\nand Lycopene, Blood Levels of Lycopene, and Risk of Total and Specific\nCancers in Adults: A Systematic Review and Dose-Response Meta-Analysis\nof Prospective Cohort Studies","volume":"12","author":"Balali","year":"2025","journal-title":"Front. Nutr."},{"key":"2026081508095760100_cit2","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3390\/biology11020239","article-title":"Tomatoes: An Extensive\nReview of the Associated Health Impacts of Tomatoes and Factors That\nCan Affect Their Cultivation","volume":"11","author":"Collins","year":"2022","journal-title":"Biology"},{"key":"2026081508095760100_cit3","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.3390\/ijms23041957","article-title":"Lycopene in\nthe Prevention of Cardiovascular Diseases","volume":"23","author":"Przybylska","year":"2022","journal-title":"Int.\nJ. Mol. 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Biorefin."},{"issue":"5","key":"2026081508095760100_cit40","doi-asserted-by":"publisher","first-page":"2880","DOI":"10.1021\/acs.iecr.4c01957","article-title":"Hybrid\nApproach to Predict the Effective Properties of Supercritical Carbon\nDioxide Extraction Model with Linear and Nonlinear Phase Equilibrium","volume":"64","author":"Ferreira","year":"2025","journal-title":"Ind. Eng. Chem. 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Nutr."},{"key":"2026081508095760100_cit47","doi-asserted-by":"publisher","first-page":"795","DOI":"10.3390\/antiox11040795","article-title":"Carotenoids: Dietary Sources, Extraction,\nEncapsulation, Bioavailability, and Health Benefits-A Review of Recent\nAdvancements","volume":"11","author":"Saini","year":"2022","journal-title":"Antioxidants"},{"key":"2026081508095760100_cit48","doi-asserted-by":"publisher","first-page":"7808","DOI":"10.1111\/ijfs.17005","article-title":"Lycopene and\n\u03b2-Carotene Thermal Degradation Kinetics and Colour-Antioxidant\nChanges in Gac (Momordica cochinchinensis) Fruit Aril Paste","volume":"59","author":"Syawalluddin","year":"2024","journal-title":"Inter. J. Food Sci. 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