{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T20:32:27Z","timestamp":1787085147259,"version":"build-2736575974"},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"19","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior","doi-asserted-by":"publisher","award":["1"],"award-info":[{"award-number":["1"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico","doi-asserted-by":"publisher","award":["401816\/2022-2"],"award-info":[{"award-number":["401816\/2022-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007382","name":"Universidade Federal do Par??","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100007382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to obtain and characterize NLCs from tucuma fat and evaluate them against fungal cultures. The NLCs were obtained by high-pressure homogenization of tucuma fat and carnauba wax as the oil phase and were evaluated for encapsulation efficiency (EE), drug loading (DL), zeta potential, particle size, and in vitro release kinetics over a 70-day period. Four formulations (NLC1, NLC2, NLC3, and NLC4) were prepared, showing particle size variation between 109.7 and 241.1 nm, PDI ranging from 0.16 to 0.41, and zeta potential between \u221212.7 mW and \u221227.5 mW. Only two of the four formulations were loaded with ketoconazole, presenting encapsulation efficiencies between 43.55% (NLC3) and 80.97% (NLC4), while drug loading values ranged from 2.18% (NLC3) to 4.03% (NLC4). After 70 days of storage at 8 and 28 \u00b0C, they maintained their physical characteristics (particle size, zeta potential, and PDI). The release kinetics of NLC3 and NLC4 were explained by the Korsmeyer-Peppas mathematical model. Finally, the antifungal activity of ketoconazole was improved 8-fold in NLC3 and NLC4. Finally, tucuma NLCs showed physical stability and biological efficacy.<\/jats:p>","DOI":"10.1021\/acsomega.5c11826","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T22:24:13Z","timestamp":1778106253000},"page":"27958-27969","source":"Crossref","is-referenced-by-count":0,"title":["Tucuma Fat-Based Nanostructured Lipid Carriers: Physical Stability and Antifungal Activity"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-553X","authenticated-orcid":true,"given":"Anto\u0302nio Taylon","family":"Aguiar Gomes","sequence":"first","affiliation":[{"name":"Federal University of Para\u0301 , , , ,","place":["Bele\u0301m, Para\u0301, Brazil, 66075-110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1995-9241","authenticated-orcid":true,"given":"Rayanne Rocha","family":"Pereira","sequence":"additional","affiliation":[{"name":"Federal University of Western Para\u0301 , , , ,","place":["Santare\u0301m, Para\u0301, Brazil, 68035-110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1966-6593","authenticated-orcid":true,"given":"Lindalva Maria de Meneses Costa","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Federal University of Para\u0301 , , , ,","place":["Bele\u0301m, Para\u0301, Brazil, 66075-110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naila Ferreira","family":"da Cruz","sequence":"additional","affiliation":[{"name":"Federal University of Para\u0301 , , , ,","place":["Bele\u0301m, Para\u0301, Brazil, 66075-110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree\u0301 Gyles","family":"Lynch","sequence":"additional","affiliation":[{"name":"University of Technology, Jamaica , , ,","place":["Kingston, Jamaica, 6"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patri\u0301cia Fagundes","family":"da Costa","sequence":"additional","affiliation":[{"name":"Federal University of Para\u0301 , , , ,","place":["Bele\u0301m, Para\u0301, Brazil, 66075-110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Guedes","family":"Salgado","sequence":"additional","affiliation":[{"name":"Federal University of Para\u0301 , , , ,","place":["Bele\u0301m, Para\u0301, Brazil, 66075-110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1691-1039","authenticated-orcid":true,"given":"Jose\u0301 Ota\u0301vio","family":"Carre\u0301ra Silva-Ju\u0301nior","sequence":"additional","affiliation":[{"name":"Federal University of Para\u0301 , , , ,","place":["Bele\u0301m, Para\u0301, Brazil, 66075-110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5470-0617","authenticated-orcid":true,"given":"Roseane Maria","family":"Ribeiro-Costa","sequence":"additional","affiliation":[{"name":"Federal University of Para\u0301 , , , ,","place":["Bele\u0301m, Para\u0301, Brazil, 66075-110"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"issue":"1","key":"2026081816070079300_cit1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/life14010001","article-title":"Dermatophyte Infections Worldwide: Increase in Incidence and Associated Antifungal Resistance","volume":"14","author":"Kruithoff","year":"2023","journal-title":"Life"},{"issue":"12","key":"2026081816070079300_cit2","doi-asserted-by":"publisher","first-page":"929","DOI":"10.3390\/gels9120929","article-title":"Development and Characterization of Econazole Topical Gel","volume":"9","author":"Bayan","year":"2023","journal-title":"Gels"},{"key":"2026081816070079300_cit3","doi-asserted-by":"publisher","first-page":"102237","DOI":"10.1016\/j.mib.2022.102237","article-title":"Antifungal Drug-Resistance Mechanisms in Candida Biofilms","volume":"71","author":"Kaur","year":"2023","journal-title":"Curr. 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