{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:13:49Z","timestamp":1791724429780,"version":"4.3.4"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JPMJCR2332"],"award-info":[{"award-number":["JPMJCR2332"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JPMJTR214C"],"award-info":[{"award-number":["JPMJTR214C"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014423","name":"Environmental Restoration and Conservation Agency","doi-asserted-by":"publisher","award":["JPMEERF20235003"],"award-info":[{"award-number":["JPMEERF20235003"]}],"id":[{"id":"10.13039\/100014423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report the development and characterization of stationary phases based on metal\u2013organic frameworks (MOFs) composed of metal ions and organic ligands for use in high-performance liquid chromatography (HPLC). In particular, we focus on a subnanoporous MOF, [Zn2(1,4-ndc)2(ted)]n (Zn-NDC; ndc = naphthalenedicarboxylate, ted = triethylenediamine), exploiting its intrinsic molecular adsorption and recognition capabilities to enhance chromatographic selectivity and efficiency. Zn-NDC was successfully immobilized onto silica monoliths through surface modification. The silica monolith substrate, functionalized with tertiary amine groups, enabled the stable and uniform attachment of Zn-NDC, leading to the successful preparation of a silica monolith modified with Zn-NDC (MOF-monolith). The MOF-monolith column exhibited distinct chromatographic behavior compared with a conventional packed-bed MOF column containing bulk Zn-NDC particles, suggesting that the continuous porous structure and surface chemistry of the silica monolith significantly influence analyte retention mechanisms. Furthermore, when C18 fatty acid methyl esters were employed as analytes, the addition of ether compounds to a mobile phase dramatically altered their elution times and produced sharp, symmetric peak shapes. This phenomenon implies the existence of specific interactions between the ether functionalities and the Zn-NDC framework, highlighting the potential of MOF\u2013silica hybrid monoliths as tunable and efficient stationary phases for advanced HPLC separations.<\/jats:p>","DOI":"10.1021\/acsomega.5c12770","type":"journal-article","created":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T14:53:02Z","timestamp":1771771982000},"page":"15328-15336","source":"Crossref","is-referenced-by-count":1,"title":["Fabrication of\nMOF-Functionalized Silica Monoliths\nand Their Unique Retention Behavior in HPLC"],"prefix":"10.1021","volume":"11","author":[{"given":"Keigo","family":"Matsubara","sequence":"first","affiliation":[{"name":"Kyoto University , , Katsura , Nishikyo-ku, ,","place":["Kyoto, Japan, 615-8510"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4145-0046","authenticated-orcid":true,"given":"Nobuhiko","family":"Hosono","sequence":"additional","affiliation":[{"name":"The University of Tokyo , , ,","place":["Tokyo, Japan, 113-8656"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1357-3196","authenticated-orcid":true,"given":"Takashi","family":"Uemura","sequence":"additional","affiliation":[{"name":"The University of Tokyo , , ,","place":["Tokyo, Japan, 113-8656"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Konishi-Yamada","sequence":"additional","affiliation":[{"name":"Kyoto Prefectural University , , 1-5 Shimogamo Hangi-cho , Sakyo-ku, ,","place":["Kyoto, Japan, 606-8522"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9274-3295","authenticated-orcid":true,"given":"Takuya","family":"Kubo","sequence":"additional","affiliation":[{"name":"Kyoto University , , Katsura , Nishikyo-ku, ,","place":["Kyoto, Japan, 615-8510"]},{"name":"Kyoto Prefectural University , , 1-5 Shimogamo Hangi-cho , Sakyo-ku, ,","place":["Kyoto, Japan, 606-8522"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,2,22]]},"reference":[{"key":"2026081508103327900_cit1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1021\/cr300014x","article-title":"Introduction to metal\u2013organic\nframeworks","volume":"112","author":"Zhou","year":"2012","journal-title":"ACS Publications"},{"issue":"5","key":"2026081508103327900_cit2","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1039\/b200393g","article-title":"Metal-organic\nframeworks","volume":"32","author":"James","year":"2003","journal-title":"Chem. 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Part 1: theoretical considerations\nand proof of concept","volume":"93","author":"Fekete","year":"2021","journal-title":"Anal. Chem."},{"issue":"52","key":"2026081508103327900_cit34","doi-asserted-by":"publisher","first-page":"20475","DOI":"10.1021\/acs.analchem.4c04418","article-title":"Transcending Resolution\nLimits in HPLC and Diffusion NMR","volume":"96","author":"Hamed","year":"2024","journal-title":"Anal. 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