{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:18:32Z","timestamp":1788218312164,"version":"build-2803163510"},"reference-count":80,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013078","name":"Natural Science Research Project of Guizhou Province","doi-asserted-by":"publisher","award":["QianKeHe Foundation [2020]1Y375"],"award-info":[{"award-number":["QianKeHe Foundation [2020]1Y375"]}],"id":[{"id":"10.13039\/501100013078","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Chinese Medicinal Materials, Guizhou University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["Gui ZhongYi ZX Hezi[2024]047"],"award-info":[{"award-number":["Gui ZhongYi ZX Hezi[2024]047"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Guizhou Provincial Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["Qian ZhongYao Han [2024] 22"],"award-info":[{"award-number":["Qian ZhongYao Han [2024] 22"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Arisaema decipiens(A. decipiens), a traditional Chinese folk medicine, is recognized for its anti-inflammatory and analgesic properties. In this study, we report the extraction, purification, and anti-inflammatory mechanisms of C-glycosides from A. decipiens (ADCG). We developed an integrated strategy for the efficient enrichment and identification of polar C-glycosides from A. decipiens. Sample pretreatment via freeze-drying preserved thermolabile constituents, and reflux extraction with 60% aqueous ethanol optimized polar compound recovery. A key innovation was the implementation of a repeated-loading strategy using polyamide resin chromatography, which significantly enhanced the dynamic adsorption capacity and prevented leakage of target analytes. This approach achieved a 15.8-fold enrichment of target C-glycosides and enabled the identification of seven compounds, including chrysin- and apigenin-based derivatives. It effectively provides an efficient and cost-effective approach for the large-scale enrichment of this fraction. ADCG significantly suppressed granuloma formation in a cotton ball-induced model. In vitro, ADCG demonstrated potent anti-inflammatory effects in LPS-stimulated RAW264.7 macrophages by dose-dependently inhibiting the production of NO, TNF-\u03b1, and IL-6, without inducing cytotoxicity. In TNF-\u03b1-induced human rheumatoid arthritis synovial MH7A cells, ADCG inhibited proliferation, migration, invasion, and the secretion of pro-inflammatory mediators IL-6, IL-8, IL-1\u03b2, and MMP-1. Mechanistic investigations combining molecular docking and Western blot analysis revealed that ADCG directly inhibits NF-\u03baB activation by suppressing I\u03baB\u03b1 degradation and p65 phosphorylation, thereby blocking nuclear translocation and the expression of downstream pro-inflammatory genes. Furthermore, constituents of ADCG exhibited high binding affinity for JAK2 and EGFR, suggesting a potential multitarget mechanism. These findings underscore the potential of ADCG as a complementary therapeutic agent for inflammatory diseases, particularly rheumatoid arthritis, and provide important insights into its molecular mechanisms of action.<\/jats:p>","DOI":"10.1021\/acsomega.5c13026","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:02:10Z","timestamp":1786377730000},"page":"48983-49000","source":"Crossref","is-referenced-by-count":0,"title":["Extraction, Purification\nof C-Glycosides from\nArisaema decipiens for Studying its Anti-Inflammatory and Bioactivities"],"prefix":"10.1021","volume":"11","author":[{"given":"Xi-Cheng","family":"He","sequence":"first","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine , , ,","place":["Guiyang, China, 550025"]},{"name":"Guizhou Inheritance Base of Traditional Chinese Medicine Processing Technology , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-fen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7634-4606","authenticated-orcid":true,"given":"Shan-shan","family":"Wu","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine , , ,","place":["Guiyang, China, 550025"]},{"name":"Guizhou Inheritance Base of Traditional Chinese Medicine Processing Technology , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Yang","family":"Du","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine , ,","place":["Guiyang, China, 550001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Du","sequence":"additional","affiliation":[{"name":"Guizhou University of Traditional Chinese Medicine , , ,","place":["Guiyang, China, 550025"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"2026083119123149600_cit1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.16041\/j.cnki.cn15-1175.2020.05.027","article-title":"Arisaema decipiens\nresearch progress","volume":"26","author":"Wu","year":"2020","journal-title":"J. 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