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Notably, in the \u03b1-tosyloxylation of ketones, the catalyst delivered up to 85% yield and 75% ee. Comparative studies showed superior selectivity over analogs with C2 symmetry, which yielded racemic products. Density function theory (DFT) studies revealed a key stereodetermining complex in the reaction mechanism, supporting the origin of the enantioselectivity. The broad substrate scope demonstrates the versatility of the catalyst. These results emphasize the value of the C1-symmetric design for chiral hypervalent iodine catalysis.<\/jats:p>","DOI":"10.1021\/acsomega.5c13099","type":"journal-article","created":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T14:52:26Z","timestamp":1771771946000},"page":"15429-15441","source":"Crossref","is-referenced-by-count":1,"title":["Structural Tuning of Inefficient\n                    <i>C<\/i>\n                    1\u2011Symmetric\nIodoarene for Efficient Enantioselective\nOxidative Organocatalysis"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2776-9385","authenticated-orcid":true,"given":"Kondapalli","family":"Pavankumar","sequence":"first","affiliation":[{"name":"Gachon University , , 191 Hambakmoeiro , Yeonsu-gu, ,","place":["Incheon, Republic of Korea, 21936"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra P.","family":"Shirke","sequence":"additional","affiliation":[{"name":"Gachon University , , 191 Hambakmoeiro , Yeonsu-gu, ,","place":["Incheon, Republic of Korea, 21936"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Kim","sequence":"additional","affiliation":[{"name":"Gachon University , , 191 Hambakmoeiro , Yeonsu-gu, ,","place":["Incheon, Republic of Korea, 21936"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhargav Gupta","family":"Nangunuri","sequence":"additional","affiliation":[{"name":"Gachon University , , 191 Hambakmoeiro , Yeonsu-gu, ,","place":["Incheon, Republic of Korea, 21936"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2718-5637","authenticated-orcid":true,"given":"Mi-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Gachon University , , 191 Hambakmoeiro , Yeonsu-gu, ,","place":["Incheon, Republic of Korea, 21936"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,2,22]]},"reference":[{"issue":"24","key":"2026081508112974600_cit1","doi-asserted-by":"publisher","first-page":"12033","DOI":"10.1021\/acs.chemrev.9b00338","article-title":"Chiral Hypervalent\nIodines: Active Players in Asymmetric Synthesis","volume":"119","author":"Parra","year":"2019","journal-title":"Chem. 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