{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:58:32Z","timestamp":1780999112714,"version":"3.54.1"},"reference-count":45,"publisher":"American Chemical Society (ACS)","issue":"22","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda????o de Amparo ?? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APD-01649-25"],"award-info":[{"award-number":["APD-01649-25"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda????o de Amparo ?? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00043-21"],"award-info":[{"award-number":["APQ-00043-21"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda????o de Amparo ?? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00544-23"],"award-info":[{"award-number":["APQ-00544-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda????o de Amparo ?? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-01123-23"],"award-info":[{"award-number":["APQ-01123-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda????o de Amparo ?? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-01287-24"],"award-info":[{"award-number":["APQ-01287-24"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda????o de Amparo ?? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-01962-18"],"award-info":[{"award-number":["APQ-01962-18"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda????o de Amparo ?? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-02221-24"],"award-info":[{"award-number":["APQ-02221-24"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda????o de Amparo ?? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-04299-22"],"award-info":[{"award-number":["APQ-04299-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda????o de Amparo ?? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-05218-23"],"award-info":[{"award-number":["APQ-05218-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico","doi-asserted-by":"publisher","award":["304302\/2025-2"],"award-info":[{"award-number":["304302\/2025-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient??fico e Tecnol??gico","doi-asserted-by":"publisher","award":["INCT-INOFAR - 402176\/2024-3"],"award-info":[{"award-number":["INCT-INOFAR - 402176\/2024-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena????o de Aperfei??oamento de Pessoal de N??vel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2026,6,9]]},"DOI":"10.1021\/acsomega.5c13239","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T04:08:46Z","timestamp":1779854926000},"page":"32242-32251","source":"Crossref","is-referenced-by-count":0,"title":["Leishmanicidal Activity of a Hydrazone Derivative Loaded into Nanocarrier Systems"],"prefix":"10.1021","volume":"11","author":[{"given":"Juliana B.","family":"Nunes","sequence":"first","affiliation":[{"name":"Biomedical Sciences Institute, Pathology and Parasitology Department","place":["Alfenas, Brazil"]},{"name":"Alfenas Federal University (UNIFAL-MG)","place":["Alfenas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalles H. F.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Institute, Pathology and Parasitology Department","place":["Alfenas, Brazil"]},{"name":"Alfenas Federal University (UNIFAL-MG)","place":["Alfenas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda S.","family":"Lima","sequence":"additional","affiliation":[{"name":"Nutrition School","place":["Alfenas, Brazil"]},{"name":"Alfenas Federal University (UNIFAL-MG)","place":["Alfenas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara O. C.","family":"Lopes","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Alfenas Federal University (UNIFAL-MG)","place":["Alfenas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelly F.","family":"Ferraz de Souza","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Alfenas Federal University (UNIFAL-MG)","place":["Alfenas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00edne P.","family":"Amaral","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Institute, Microbiology and Immunology Department","place":["Alfenas, Brazil"]},{"name":"Alfenas Federal University (UNIFAL-MG)","place":["Alfenas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislaine R.","family":"Pereira","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Alfenas Federal University (UNIFAL-MG)","place":["Alfenas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio A.","family":"Colombo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Alfenas Federal University (UNIFAL-MG)","place":["Alfenas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7883-9717","authenticated-orcid":true,"given":"Eduardo C.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Alfenas Federal University (UNIFAL-MG)","place":["Alfenas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Nutrition School","place":["Alfenas, Brazil"]},{"name":"Alfenas Federal University (UNIFAL-MG)","place":["Alfenas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-384X","authenticated-orcid":true,"given":"Luiz F.","family":"Leomil Coelho","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Institute, Microbiology and Immunology Department","place":["Alfenas, Brazil"]},{"name":"Alfenas Federal University (UNIFAL-MG)","place":["Alfenas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1572-2581","authenticated-orcid":true,"given":"Luis F.","family":"Cunha dos Reis","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Institute, Structural Biology Department","place":["Alfenas, Brazil"]},{"name":"Alfenas Federal University (UNIFAL-MG)","place":["Alfenas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8625-6351","authenticated-orcid":true,"given":"L\u00eddia M.","family":"Lima","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Federal University of Rio de Janeiro (UFRJ), Av. Carlos Chagas Filho, 373, Cidade Universit\u00e1ria, Rio de Janeiro, Rio de Janeiro 21941-902, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos J.","family":"Marques","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Institute, Pathology and Parasitology Department","place":["Alfenas, Brazil"]},{"name":"Alfenas Federal University (UNIFAL-MG)","place":["Alfenas, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmac134"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-022-00726-8"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8030119"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1000972"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2018.09.006"},{"key":"ref6\/cit6","unstructured":"de Queiroz, A. C. Estudos in vitro e in vivo da atividade leishmanicida de novos derivados sint\u00e9ticos. 2015. 320 fl. Doutorado Rede Nordeste de Biotecnologia, Ph.D. Thesis, Universidade Federal de Alagoas, 2015."},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0269447"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S140363"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-023-05676-8"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2016.04.037"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2024.104001"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2023.213434"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2023.106896"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2019.111558"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.08.070"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111523"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2018.07.003"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.126167"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.07.024"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3646"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1080\/00498254.2017.1405465"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1039\/d0ra00287a"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155838"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.3.1912"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2024.107141"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2017.12.005"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-016-0025-2"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.1993.tb00033.x"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.043893"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.80"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1515\/bchm2.1978.359.2.1561"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.04.034"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28962"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001155"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9186-0"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156733"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S467876"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.2174\/1566524043360186"},{"key":"ref39\/cit39","unstructured":"de Queiroz, A. C.; Tanuri, A.; Barreiros, E. J. L.; Meyer, H. E. C.; Moreira, M. A. S.; Gonz\u00e1lez-Hormaizteguy, M. M.; Alves, M. A. Hydrazide-N-Acylhydrazone Compounds, Process for Obtaining Hydrazide-N-Acylhydrazones, Use Thereof for the Treatment of Leishmaniasis and Chagas Disease, and Pharmaceutical Compositions. BR 1020120190958 A2, 2015."},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-08386-0"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2020.105539"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01936-13"},{"key":"ref43\/cit43","first-page":"97","volume":"22","author":"Rich L.","year":"2005","journal-title":"J. morphol. Sci."},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106611"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1293\/tox.2017-0031"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c13239","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c13239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:09:22Z","timestamp":1780996162000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c13239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":45,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2026,6,9]]}},"alternative-id":["10.1021\/acsomega.5c13239"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c13239","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,27]]}}}