{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T09:11:54Z","timestamp":1776157914018,"version":"3.50.1"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"14","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2011\/509634"],"award-info":[{"award-number":["2011\/509634"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2013\/074671"],"award-info":[{"award-number":["2013\/074671"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2022\/15421-0"],"award-info":[{"award-number":["2022\/15421-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","award":["04.11.0043.06"],"award-info":[{"award-number":["04.11.0043.06"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","award":["04.16.0054.02"],"award-info":[{"award-number":["04.16.0054.02"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2026,4,14]]},"DOI":"10.1021\/acsomega.5c13455","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:21:58Z","timestamp":1775024518000},"page":"22148-22157","source":"Crossref","is-referenced-by-count":0,"title":["Protein Large Language Models Can Predict\n                    <i>Flavivirus<\/i>\n                    Protease Target Specificity"],"prefix":"10.1021","volume":"11","author":[{"given":"Rafael","family":"Montilla","sequence":"first","affiliation":[{"name":"Department of Science and Technology, Biochemistry and Structural Biology Laboratory","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]},{"name":"Federal University of S\u00e3o Paulo - UNIFESP","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Let\u00edcia Dias Lima","family":"Jedlicka","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Functional Proteomics Laboratory","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]},{"name":"Federal University of S\u00e3o Paulo - UNIFESP","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]},{"name":"Institute of Health and Biological Studies","place":["Marab\u00e1, Brazil"]},{"name":"Federal University of Southern and Southeastern Par\u00e1 - UNIFESSPA","place":["Marab\u00e1, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uilla","family":"Barcick","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Functional Proteomics Laboratory","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]},{"name":"Federal University of S\u00e3o Paulo - UNIFESP","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murilo","family":"Salardani","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Functional Proteomics Laboratory","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]},{"name":"Federal University of S\u00e3o Paulo - UNIFESP","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6017-6671","authenticated-orcid":true,"given":"Alison Felipe Alencar","family":"Chaves","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Toxinology, Center of Toxins","place":["S\u00e3o Paulo, Brazil"]},{"name":"Immune-Response and Cell Signaling (CeTICS)","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Biochemistry and Structural Biology Laboratory","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]},{"name":"Federal University of S\u00e3o Paulo - UNIFESP","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Biochemistry and Structural Biology Laboratory","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]},{"name":"Federal University of S\u00e3o Paulo - UNIFESP","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6904-8681","authenticated-orcid":true,"given":"Camila","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Biochemistry and Structural Biology Laboratory","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]},{"name":"Federal University of S\u00e3o Paulo - UNIFESP","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Slivka","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Biochemistry and Structural Biology Laboratory","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]},{"name":"Federal University of S\u00e3o Paulo - UNIFESP","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Zelanis","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Functional Proteomics Laboratory","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]},{"name":"Federal University of S\u00e3o Paulo - UNIFESP","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8571-419X","authenticated-orcid":true,"given":"Martin","family":"W\u00fcrtele","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Biochemistry and Structural Biology Laboratory","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]},{"name":"Federal University of S\u00e3o Paulo - UNIFESP","place":["S\u00e3o Jos\u00e9 dos Campos, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059026"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05775"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nature06536"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s40101-020-00239-5"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30727-2"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24748"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8020266"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-14243-5"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202100695"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2022.104132"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3201\/eid1108.050289a"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.8042"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/v11070640"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/v15010077"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2023.28.33.2200929"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/v13112293"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3390\/life11070615"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2012.12.001"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2023.101305"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2023.199222"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/v11100961"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2022.170814"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.3c00054"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02946-24"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1126\/science.adv4414"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041458"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2024.09.031"},{"key":"ref28\/cit28","unstructured":"Vaswani, A.; Shazeer, N.; Parmar, N.; Uszkoreit, J.; Jones, L.; Gomez, A. N.; Kaiser, \u0141.; Polosukhin, I. Attention Is All You Need. In\n                      Proceedings of the 31st International Conference on Neural Information Processing Systems; NIPS\u201917\n                      ; Curran Associates Inc.: Red Hook, NY, USA, 2017, pp 6000\u20136010."},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2022.11.001"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2025.102984"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.2021.3095381"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.178"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.2c00624"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201200439"},{"key":"ref35\/cit35","first-page":"461","volume-title":"Methods in Enzymology","volume":"374","author":"Fiser A.","year":"2003"},{"key":"ref36\/cit36","unstructured":"DeLano, W. L.\n                      The PyMOL User\u2019s Manual\n                      ; DeLano Scientific: San Carlos: California, USA, 2022."},{"key":"ref37\/cit37","unstructured":"The PyMOL Molecular\nGraphics System\n                      , version 1.8; 2015."},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3280"},{"key":"ref39\/cit39","unstructured":"Hayou, S.; Ghosh, N.; Yu, B. LoRA+: Efficient Low Rank Adaptation of Large Models. In\n                      Proceedings of the 41st International Conference on Machine Learning\n                      ; ICML\u201924; JMLR.org: Vienna, Austria, 2024; Vol. 235, pp 17783\u201317806."},{"key":"ref40\/cit40","first-page":"2825","volume":"12","author":"Pedregosa F.","year":"2011","journal-title":"J. Mach. Learn. Res."},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20061136"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.6b00131"},{"key":"ref43\/cit43","volume":"28","author":"Katzenmeier G.","year":"2004","journal-title":"Dengue Bull."},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1110\/ps.072753207"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.382"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-024-02525-x"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2016239118"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c13455","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c13455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:21:32Z","timestamp":1776154892000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c13455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":48,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,4,14]]}},"alternative-id":["10.1021\/acsomega.5c13455"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c13455","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]}}}