{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:58:44Z","timestamp":1780999124491,"version":"3.54.1"},"reference-count":93,"publisher":"American Chemical Society (ACS)","issue":"22","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009455","name":"West Virginia University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009455","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["5P20GM121322"],"award-info":[{"award-number":["5P20GM121322"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103434"],"award-info":[{"award-number":["P20GM103434"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2026,6,9]]},"DOI":"10.1021\/acsomega.5c13457","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T18:24:43Z","timestamp":1779733483000},"page":"32321-32335","source":"Crossref","is-referenced-by-count":0,"title":["Delivery of Monomethyl Auristatin E Using Ionizable Lipid Nanoparticles for B-Cell Acute Lymphoblastic Leukemia Treatment"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8921-8211","authenticated-orcid":true,"given":"William H.","family":"Pentz","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences","place":["Morgantown, United States"]},{"name":"West Virginia University School of Pharmacy","place":["Morgantown, United States"]},{"name":"School of Medicine, West Virginia University","place":["Morgantown, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-223X","authenticated-orcid":true,"given":"Krystal A.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences","place":["Morgantown, United States"]},{"name":"West Virginia University School of Pharmacy","place":["Morgantown, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6113-4091","authenticated-orcid":true,"given":"Bishal","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences","place":["Morgantown, United States"]},{"name":"West Virginia University School of Pharmacy","place":["Morgantown, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikiran V.","family":"Nandigama","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry","place":["Buckhannon, United States"]},{"name":"West Virginia Wesleyan College","place":["Buckhannon, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6435-9616","authenticated-orcid":true,"given":"Aidan","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Cell Biology","place":["Morgantown, United States"]},{"name":"West Virginia University School of Medicine","place":["Morgantown, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimery","family":"Samuelson","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Berea, United States"]},{"name":"Berea College","place":["Berea, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Surface","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy","place":["Morgantown, United States"]},{"name":"West Virginia University School of Pharmacy","place":["Morgantown, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukiye Nur","family":"Akpolat-Seker","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences","place":["Morgantown, United States"]},{"name":"West Virginia University School of Pharmacy","place":["Morgantown, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boopalan","family":"Sivanathan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences","place":["Morgantown, United States"]},{"name":"West Virginia University School of Pharmacy","place":["Morgantown, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0740-330X","authenticated-orcid":true,"given":"Sharan","family":"Bobbala","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences","place":["Morgantown, United States"]},{"name":"West Virginia University School of Pharmacy","place":["Morgantown, United States"]},{"name":"West Virginia University Cancer Institute","place":["Morgantown, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02112-8"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.04.015"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1624007"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00811-9"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1637958"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c04996"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1660970"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.07.011"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-18-0801"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33018-1"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.8018"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.48"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.280451"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1325255"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.2991\/chi.d.190503.002"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.923419"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02395-4"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2015.01.003"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2024.0051"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.2309"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2013.10.012"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122615"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160890"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107778"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/abt\/tbaf005"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-179143"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1235273"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.omto.2021.04.013"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2013.06.027"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251719"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1039\/D4NR00278D"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/nbt832"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14102131"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24108543"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","DOI":"10.2174\/97816810868731180101","volume-title":"Fundamentals of Medicinal Chemistry and Drug Metabolism","author":"Khan M. O. F.","year":"2018"},{"key":"ref37\/cit37","unstructured":"PubChem. Monomethylauristatin\nE 2025, https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/11542188. (accessed October 3, 2025)."},{"key":"ref38\/cit38","unstructured":"U.S. Food Drug Administration. ONPATTRO- Patisiran Injection, Lipid Complex 2026 https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=e87ec36f-b4b4-49d4-aea4-d4ffb09b0970. (accessed March 30, 2026)."},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084103"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00498"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03713-y"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12030288"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-025-01029-7"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2024.104070"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114416"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.115175"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialsau.4c00158"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-198-1_6"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-63651-4"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252011254"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines13040339"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2612"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2018.09.068"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2021.100993"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00858-8"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200908086"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/nature14067"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.892169"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12370"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.2969"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11350"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2024.2356255"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2307800120"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM01609H"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2307809121"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2025.101436"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10061332"},{"issue":"9","key":"ref68\/cit68","first-page":"1195","volume":"65","author":"Pastuskovas C. V.","year":"2005","journal-title":"Cancer Res."},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2025.2541024"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202304378"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5c00385"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202103025"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM01846B"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.02.055"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2015.00210"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2016.00162"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c16936"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010150"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2023.116624"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2911"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-080325"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031054"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1038\/nri3087"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00328"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48838-5"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2011.553218"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.11.029"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00071"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15061603"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31774-X"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-023-03947-w"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-025-01073-2"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c14203"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c13457","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.5c13457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T09:10:42Z","timestamp":1780996242000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.5c13457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":93,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2026,6,9]]}},"alternative-id":["10.1021\/acsomega.5c13457"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.5c13457","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]}}}