{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:13:03Z","timestamp":1788221583600,"version":"build-2803163510"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? i Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2022\/05327-7"],"award-info":[{"award-number":["2022\/05327-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["163647\/2022-4"],"award-info":[{"award-number":["163647\/2022-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["311218\/2025-3"],"award-info":[{"award-number":["311218\/2025-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda??o Carlos Chagas Filho de Amparo ? i Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/201.158\/2022"],"award-info":[{"award-number":["E-26\/201.158\/2022"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Among tropical neglected diseases, leishmaniasis stands out. This parasitic infection occurs in numerous countries, affecting thousands of people worldwide. The currently available therapies present important limitations, including high toxicity, long treatment periods requiring parenteral administration, and the emergence of parasite resistance. Based on the known antileishmanial properties of eugenol and its derivatives, a series of novel disubstituted 1,2,3-triazoles was prepared via the classical 1,3-dipolar cycloaddition reaction, employing a eugenol-azide derivative. These compounds were subsequently evaluated against Leishmania amazonensis (promastigotes and amastigotes). Compound 4d emerged as the most active molecule in the series, exhibiting an IC50 = 3.98 \u00b1 1.05 \u03bcM against amastigotes and a selectivity index greater than 50.25, thereby retaining and even enhancing the antileishmanial activity of its natural-product precursor.<\/jats:p>","DOI":"10.1021\/acsomega.5c13551","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T10:01:46Z","timestamp":1786528906000},"page":"49026-49032","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis,\nand Antileishmanial Activity of\nNovel C6-Substituted Eugenol Derivatives with a Triazole Linker"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0662-3519","authenticated-orcid":true,"given":"Henrique P.","family":"Orenha","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeira\u0303o Preto \u2212 University of Sa\u0303o Paulo , , Avenida do Cafe\u0301 s\/n, Vila Monte Alegre , , ,","place":["Ribeira\u0303o Preto, SP, Brazil, 14040-903"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana M. 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U.","family":"Moncorvo","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Institute \u2212 Fiocruz , , Avenida Brasil 4365 , Manguinhos, , ,","place":["Rio de Janeiro, RJ, Brazil, 21040-360"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-8604","authenticated-orcid":true,"given":"Thiago","family":"dos Santos","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeira\u0303o Preto \u2212 University of Sa\u0303o Paulo , , Avenida do Cafe\u0301 s\/n, Vila Monte Alegre , , ,","place":["Ribeira\u0303o Preto, SP, Brazil, 14040-903"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Espi\u0301rito Santo da","family":"Silva","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Institute \u2212 Fiocruz , , Avenida Brasil 4365 , Manguinhos, , ,","place":["Rio de Janeiro, RJ, Brazil, 21040-360"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor H. C.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeira\u0303o Preto \u2212 University of Sa\u0303o Paulo , , Avenida do Cafe\u0301 s\/n, Vila Monte Alegre , , ,","place":["Ribeira\u0303o Preto, SP, Brazil, 14040-903"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2240-4519","authenticated-orcid":true,"given":"Eduardo Caio","family":"Torres-Santos","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Institute \u2212 Fiocruz , , Avenida Brasil 4365 , Manguinhos, , ,","place":["Rio de Janeiro, RJ, Brazil, 21040-360"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7605-4150","authenticated-orcid":true,"given":"Giuliano C.","family":"Clososki","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeira\u0303o Preto \u2212 University of Sa\u0303o Paulo , , Avenida do Cafe\u0301 s\/n, Vila Monte Alegre , , ,","place":["Ribeira\u0303o Preto, SP, Brazil, 14040-903"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"2026083119134516200_cit1","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.bioorg.2018.10.059","article-title":"Antileishmanial\nactivity and ultrastructural changes of sesquiterpene lactones isolated\nfrom Calea pinnatifida (Asteraceae)","volume":"83","author":"Caldas","year":"2019","journal-title":"Bioorg.\nChem."},{"key":"2026083119134516200_cit2","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.ejmech.2018.01.046","article-title":"Synthesis and leishmanicidal activity of eugenol derivatives\nbearing 1,2,3-triazole functionalities","volume":"146","author":"Teixeira","year":"2018","journal-title":"Eur.\nJ. Med. Chem."},{"key":"2026083119134516200_cit3","unstructured":"Centers for Disease Control and Prevention (CDC), c2017.\n          . DPDx - Laboratory Identification\nof Parasites of Public Health Concern; Leishmaniasis. https:\/\/www.cdc.gov\/dpdx\/leishmaniasis\/index.html."},{"issue":"1","key":"2026083119134516200_cit4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.idc.2018.10.005","article-title":"Visceral Leishmaniasis: Recent Advances\nin Diagnostics and Treatment Regimens","volume":"33","author":"Van Griensven","year":"2019","journal-title":"Infect.\nDis. Clin. North Am."},{"issue":"6","key":"2026083119134516200_cit5","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.jaad.2014.09.014","article-title":"Cutaneous and mucocutaneous leishmaniasis: Clinical\nperspectives","volume":"73","author":"Handler","year":"2015","journal-title":"J. Am. Acad. 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Leishmaniasis\n| Number of Cases of Cutaneous Leishmaniasis Reported, 2023. https:\/\/apps.who.int\/neglected_diseases\/ntddata\/leishmaniasis\/leishmaniasis.html."},{"key":"2026083119134516200_cit8","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.actatropica.2016.08.026","article-title":"Effects\nof linalool and eugenol on\nthe survival of Leishmania (L.) infantum chagasi within macrophages","volume":"164","author":"Dutra","year":"2016","journal-title":"Acta Trop."},{"key":"2026083119134516200_cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174436","article-title":"Advancement in leishmaniasis\ndiagnosis and therapeutics: An update","volume":"910","author":"Kumari","year":"2021","journal-title":"Eur.\nJ. 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