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In this study, HDL nanoparticles with different molar fractions of gadolinium lipids (0 &amp;lt; xGd-lipids &amp;lt; 0.33) were prepared, and the MR relaxivity values (r1 and r2) for all compositions were measured. Both r1 and r2 parameters reached a maximal value at a molar fraction of approximately xGd-lipids = 0.2. Higher payloads of gadolinium did not significantly increase relaxivity values but induced changes in the structure of HDL, increasing the size of the particles from dH = 8.2 \u00b1 1.6 to 51.7 \u00b1 7.3 nm. High payloads of gadolinium lipids trigger conformational changes in HDL, with potential effects on the in vivo behavior of the nanoparticles.<\/jats:p>","DOI":"10.1021\/acsomega.6b00108","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T06:21:25Z","timestamp":1474870885000},"page":"470-475","source":"Crossref","is-referenced-by-count":4,"title":["Conformational Changes in High-Density Lipoprotein\nNanoparticles Induced by High Payloads of Paramagnetic Lipids"],"prefix":"10.1021","volume":"1","author":[{"given":"Pedro","family":"Ramos-Cabrer","sequence":"first","affiliation":[{"name":"CIC biomaGUNE , , Paseo Miramo\u0301n 182 , ,","place":["Donostia-San Sebastia\u0301n, Spain, 20009"]},{"name":"Ikerbasque, Basque Foundation for Science , Maria Diaz de Haro 3 , ,","place":["Bilbao, Spain, 48011"]},{"name":"University Clinical Hospital Santiago, Health Sciences Institute (IDIS) , , Travesa da choupana s\/n , ,","place":["Santiago de Compostela, Spain, 15706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Fay","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai , , One Gustave Levy Place , , ,","place":["New York, New York, United States, 10029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda L.","family":"Sanchez-Gaytan","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai , , One Gustave Levy Place , , ,","place":["New York, New York, United States, 10029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tang","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai , , One Gustave Levy Place , , ,","place":["New York, New York, United States, 10029"]},{"name":"Memorial Sloan Kettering Cancer Center , , 1275 York Avenue , , ,","place":["New York, New York, United States, 10065"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301","family":"Castillo","sequence":"additional","affiliation":[{"name":"University Clinical Hospital Santiago, Health Sciences Institute (IDIS) , , Travesa da choupana s\/n , ,","place":["Santiago de Compostela, Spain, 15706"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahi A.","family":"Fayad","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai , , One Gustave Levy Place , , ,","place":["New York, New York, United States, 10029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem J. 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