{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:58:17Z","timestamp":1793159897285,"version":"4.5.0"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T00:00:00Z","timestamp":1486598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31271021"],"award-info":[{"award-number":["31271021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31525009"],"award-info":[{"award-number":["31525009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2013DFG52300"],"award-info":[{"award-number":["2013DFG52300"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2015AA020316"],"award-info":[{"award-number":["2015AA020316"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["2011SCU04B18"],"award-info":[{"award-number":["2011SCU04B18"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Sichuan Province","doi-asserted-by":"publisher","award":["2016TD0004"],"award-info":[{"award-number":["2016TD0004"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A great interest has been shown in the injectable scaffolds for cartilage tissue regeneration because it can fill irregularly shaped defects easily through minimally invasive surgical treatments. Herein, we developed a new injectable three-dimensional (3D) alginate hydrogel loaded with biodegradable porous poly(\u03b5-caprolactone)\u2013b-poly(ethylene glycol)\u2013b-poly(\u03b5-caprolactone) microspheres (MPs\/Alg) as the calcium gluconate container to cross-link alginate. Suspensions of chondrocytes\/alginate and porous microspheres turned into a gel because of the release of calcium gluconate; thus, the injectable composite hydrogels give a 3D scaffold to fit the defects perfectly and integrate the extracellular-matrix-mimicking architecture to efficiently accommodate cartilage cells in situ. Tissue repair in a full-thickness cartilage defect model was controlled at 6, 12, and 18 weeks after the implant by micro-CT and immunohistochemistry to evaluate the healing status. The defect in the MPs\/Alg+ cells group achieved an almost complete repair at 18 weeks, and the repaired chondrocytes regained a normal tissue structure. Moreover, the MPs\/Alg+ cells-treated group increased the quality of tissue formed, including the accumulated glycosaminoglycan and the uniformly deposited type II collagen. The results point out the promising application of the injectable MPs\/Alg-chondrocytes system for cartilage tissue engineering.<\/jats:p>","DOI":"10.1021\/acsomega.6b00495","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T07:09:56Z","timestamp":1486624196000},"page":"443-454","source":"Crossref","is-referenced-by-count":91,"title":["Injectable Alginate Hydrogel Cross-Linked by Calcium\nGluconate-Loaded Porous Microspheres for Cartilage Tissue Engineering"],"prefix":"10.1021","volume":"2","author":[{"given":"JinFeng","family":"Liao","sequence":"first","affiliation":[{"name":"Sichuan University , , ,","place":["Chengdu, P. R. China, 610041"]},{"name":"Sichuan University , , ,","place":["Chengdu, P. R. 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Rep."},{"key":"2026090207350677700_cit4","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S0142-9612(99)00241-0","article-title":"Articular Cartilage Repair in Rabbits\nby Using Suspensions of Allogenic Chondrocytes in Alginate","volume":"21","author":"Fragonas","year":"2000","journal-title":"Biomaterials"},{"key":"2026090207350677700_cit5","doi-asserted-by":"publisher","first-page":"21236","DOI":"10.1021\/acsami.6b08285","article-title":"Potential\nof Agarose\/Silk Fibroin\nBlended Hydrogel for in Vitro Cartilage Engineering","volume":"8","author":"Singh","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"2026090207350677700_cit6","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009688","article-title":"Adult Human Neural Crest-derived Cells for Articular\nCartilage Repair","volume":"6","author":"Pelttari","year":"2014","journal-title":"Sci. Transl. 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