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As the mortality rate caused by sepsis due to superbugs is more than 40%, accurate identification of blood infections during the early stage will have a huge significance in the clinical setting. Here, we report the synthesis of red\/blue fluorescent carbon dot (CD)-attached magnetic nanoparticle-based multicolor multifunctional CD-based nanosystems, which can be used for selective separation and identification of superbugs from infected blood samples. The reported data show that multifunctional fluorescent magneto-CD nanoparticles are capable of isolating Methicillin-resistant Staphylococcus aureus (MRSA) and Salmonella DT104 superbug from whole blood samples, followed by accurate identification via multicolor fluorescence imaging. As multidrug-resistant (MDR) superbugs are resistant to antibiotics available in the market, this article also reports the design of antimicrobial peptide-conjugated multicolor fluorescent magneto-CDs for effective separation, accurate identification, and complete disinfection of MDR superbugs from infected blood. The reported data demonstrate that by combining pardaxin antimicrobial peptides, magnetic nanoparticles, and multicolor fluorescent CDs into a single system, multifunctional CDs represent a novel material for efficient separation, differentiation, and eradication of superbugs. This material shows great promise for use in clinical settings.<\/jats:p>","DOI":"10.1021\/acsomega.6b00518","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T14:18:49Z","timestamp":1487168329000},"page":"554-562","source":"Crossref","is-referenced-by-count":68,"title":["Fluorescent, Magnetic Multifunctional Carbon Dots\nfor Selective Separation, Identification, and Eradication of Drug-Resistant\nSuperbugs"],"prefix":"10.1021","volume":"2","author":[{"given":"Avijit","family":"Pramanik","sequence":"first","affiliation":[{"name":"Jackson State University , , 1400 J. R. Lynch Street , P.O. Box 17910, , ,","place":["Jackson, Mississippi, United States, 39217-0510"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Jones","sequence":"additional","affiliation":[{"name":"Jackson State University , , 1400 J. R. Lynch Street , P.O. Box 17910, , ,","place":["Jackson, Mississippi, United States, 39217-0510"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Pedraza","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio , , One UTSA Circle , , ,","place":["San Antonio, Texas, United States, 78249-0697"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Vangara","sequence":"additional","affiliation":[{"name":"Jackson State University , , 1400 J. R. Lynch Street , P.O. Box 17910, , ,","place":["Jackson, Mississippi, United States, 39217-0510"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Sweet","sequence":"additional","affiliation":[{"name":"Jackson State University , , 1400 J. R. Lynch Street , P.O. Box 17910, , ,","place":["Jackson, Mississippi, United States, 39217-0510"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariah S.","family":"Williams","sequence":"additional","affiliation":[{"name":"Jackson State University , , 1400 J. R. Lynch Street , P.O. Box 17910, , ,","place":["Jackson, Mississippi, United States, 39217-0510"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Ruppa-Kasani","sequence":"additional","affiliation":[{"name":"Jackson State University , , 1400 J. R. Lynch Street , P.O. Box 17910, , ,","place":["Jackson, Mississippi, United States, 39217-0510"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean Edward","family":"Risher","sequence":"additional","affiliation":[{"name":"Jackson State University , , 1400 J. R. Lynch Street , P.O. Box 17910, , ,","place":["Jackson, Mississippi, United States, 39217-0510"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhiraj","family":"Sardar","sequence":"additional","affiliation":[{"name":"University of Texas at San Antonio , , One UTSA Circle , , ,","place":["San Antonio, Texas, United States, 78249-0697"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-9930","authenticated-orcid":true,"given":"Paresh Chandra","family":"Ray","sequence":"additional","affiliation":[{"name":"Jackson State University , , 1400 J. R. Lynch Street , P.O. Box 17910, , ,","place":["Jackson, Mississippi, United States, 39217-0510"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"2026090207502297900_cit1","unstructured":"World Health Organization.\n          .  Antimicrobial Resistance: Global Report\non Surveillance 2014; WHO, 2014."},{"key":"2026090207502297900_cit2","unstructured":"http:\/\/www.who.int\/mediacentre\/factsheets\/fs194\/en\/ (accessed Dec 8, 2016)."},{"key":"2026090207502297900_cit3","unstructured":"https:\/\/www.cdc.gov\/drugresistance\/ (accessed Dec 8, 2016)."},{"key":"2026090207502297900_cit4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1021\/acsinfecdis.5b00116","article-title":"Nanomaterials for the Treatment of\nBacterial Biofilms","volume":"2","author":"Wang","year":"2016","journal-title":"ACS Infect. Dis."},{"key":"2026090207502297900_cit5","doi-asserted-by":"publisher","first-page":"16162","DOI":"10.1038\/nmicrobiol.2016.162","article-title":"Combating\nmultidrug-resistant\nGram-negative bacteria with structurally nanoengineered antimicrobial\npeptide polymers","volume":"1","author":"Lam","year":"2016","journal-title":"Nat. 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