{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:17:55Z","timestamp":1791195475067,"version":"4.1.0"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"20","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001631","name":"University College Dublin","doi-asserted-by":"publisher","award":["82934-NP\/R27885"],"award-info":[{"award-number":["82934-NP\/R27885"]}],"id":[{"id":"10.13039\/501100001631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["308789\/2022-9"],"award-info":[{"award-number":["308789\/2022-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["88881.125637\/2025-01"],"award-info":[{"award-number":["88881.125637\/2025-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2026,5,26]]},"DOI":"10.1021\/acsomega.6c00071","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T19:05:01Z","timestamp":1778785501000},"page":"29772-29786","source":"Crossref","is-referenced-by-count":1,"title":["Unlocking Biomedical Potential of the [Cu(\n                    <scp>l<\/scp>\n                    -isoleucine)(1,10-phenanthroline)(H\n                    <sub>2<\/sub>\n                    O)]Cl\u00b72H\n                    <sub>2<\/sub>\n                    O Complex: A Comprehensive Study of Synthesis, Spectroscopic Analyses, Antitumor Efficacy, and Computational Insights"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7185-7859","authenticated-orcid":true,"given":"Marinaldo V.","family":"de Souza Junior","sequence":"first","affiliation":[{"name":"Center for Sciences of Imperatriz","place":["Imperatriz, Brazil"]},{"name":"Federal University of Maranh\u00e3o \u2212 UFMA","place":["Imperatriz, Brazil"]},{"name":"UCD School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin 4 D04 V1W8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayson C.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Center for Sciences of Imperatriz","place":["Imperatriz, Brazil"]},{"name":"Federal University of Maranh\u00e3o \u2212 UFMA","place":["Imperatriz, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jad L. F.","family":"Simplicio","sequence":"additional","affiliation":[{"name":"Center for Sciences of Imperatriz","place":["Imperatriz, Brazil"]},{"name":"Federal University of Maranh\u00e3o \u2212 UFMA","place":["Imperatriz, Brazil"]},{"name":"UCD School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin 4 D04 V1W8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o G.","family":"de Oliveira Neto","sequence":"additional","affiliation":[{"name":"Center for Sciences of Imperatriz","place":["Imperatriz, Brazil"]},{"name":"Federal University of Maranh\u00e3o \u2212 UFMA","place":["Imperatriz, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila P. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"Center for Sciences of Imperatriz","place":["Imperatriz, Brazil"]},{"name":"Federal University of Maranh\u00e3o \u2212 UFMA","place":["Imperatriz, Brazil"]},{"name":"Laboratory of Pathophysiology and Therapeutic Research, Center for Social Sciences, Health and Technology","place":["Imperatriz, Brazil"]},{"name":"Federal University of Maranh\u00e3o \u2013 UFMA","place":["Imperatriz, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aramys S.","family":"Reis","sequence":"additional","affiliation":[{"name":"Center for Sciences of Imperatriz","place":["Imperatriz, Brazil"]},{"name":"Federal University of Maranh\u00e3o \u2212 UFMA","place":["Imperatriz, Brazil"]},{"name":"Laboratory of Pathophysiology and Therapeutic Research, Center for Social Sciences, Health and Technology","place":["Imperatriz, Brazil"]},{"name":"Federal University of Maranh\u00e3o \u2013 UFMA","place":["Imperatriz, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2248-5104","authenticated-orcid":true,"given":"Adenilson O.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Center for Sciences of Imperatriz","place":["Imperatriz, Brazil"]},{"name":"Federal University of Maranh\u00e3o \u2212 UFMA","place":["Imperatriz, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9247-6780","authenticated-orcid":true,"given":"Alejandro P.","family":"Ayala","sequence":"additional","affiliation":[{"name":"Department of Physics","place":["Fortaleza, Brazil"]},{"name":"Federal University of Cear\u00e1 \u2212 UFC","place":["Fortaleza, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":true,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"UCD School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin 4 D04 V1W8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3413-5520","authenticated-orcid":true,"given":"Francisco F.","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Center for Sciences of Imperatriz","place":["Imperatriz, Brazil"]},{"name":"Federal University of Maranh\u00e3o \u2212 UFMA","place":["Imperatriz, Brazil"]},{"name":"Institute of Exact and Natural Sciences","place":["Bel\u00e9m, Brazil"]},{"name":"Federal University of Par\u00e1 \u2212 UFPA","place":["Bel\u00e9m, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","unstructured":"Farkas, E.; S\u00f3v\u00e1g\u00f3, I.\n                      Metal Complexes of Amino Acids and Peptides\n                      ; Ryadnov, M.; Hudecz, F., Eds. The Royal Society of Chemistry, 2016; Vol. 41, pp 100\u2013151.","DOI":"10.1039\/9781782626619-00100"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s10853-024-09795-y"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e37505"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2020.114807"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/crat.202300240"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111658"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2025.127690"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c09973"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-024-03417-2"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/cg900133t"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(02)00378-1"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2018.01.008"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.04.008"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00543"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202303059"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28155629"},{"key":"ref17\/cit17","first-page":"461","volume":"67","author":"Chen S.","year":"2004","journal-title":"Huaxue Tongbao"},{"key":"ref18\/cit18","unstructured":"APEX4 Data Collection\nSoftware (Version 2021.4-0)\n                      ; Bruker: Madison,\nWI, 2021."},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1107\/S1600576714022985"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889808042726"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1107\/S1600576719014092"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889897003117"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/BF00549096"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/B818330A"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1039\/B203191B"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1107\/S0108768104020300"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/b704980c"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1007\/s40484-019-0172-y"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.4.2179"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444912027047"},{"key":"ref31\/cit31","unstructured":"BIOVIA Discovery\nStudio Visualizer\n                      ; Dassault Syst\u00e8mes, 2016."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/inorganics10080116"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.136197"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c02129"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.202400302"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.5935\/1984-6835.20150118"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.2174\/1573406415666190128095732"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.121921"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c03355"},{"issue":"8","key":"ref41\/cit41","first-page":"2993","volume":"29","author":"Badisa R. B.","year":"2009","journal-title":"Anticancer Res."},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.2174\/156802609789207127"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17070942"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2025.107005"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26216520"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9060330"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1007\/BF00814156"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191015584"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c00071","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c00071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:13:32Z","timestamp":1779783212000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.6c00071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":48,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,5,26]]}},"alternative-id":["10.1021\/acsomega.6c00071"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c00071","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]}}}