{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:02:52Z","timestamp":1785250972860,"version":"3.55.0"},"reference-count":66,"publisher":"American Chemical Society (ACS)","issue":"29","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell?Istruzione, dell?Universit? e della Ricerca","doi-asserted-by":"publisher","award":["20224C35S7- WITCHeS"],"award-info":[{"award-number":["20224C35S7- WITCHeS"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AGreen Food Research Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The classic drug synthesis methods applied by the pharmaceutical industry are a major source of toxic and environmentally harmful waste. Although the continuous search for increasingly effective drugs is essential, chemists and chemical engineers involved in production processes have a responsibility to adopt practices aligned with the principles of green chemistry. In this context, aquiline, a combination of choline chloride (ChCl) and water in a 1:3.33 molar ratio, representing one of the earliest examples of natural deep eutectic solvents (NADES) and water-in-salt (WiS) systems, is explored under different conditions as an environmental reaction medium for the synthesis of several 4-quinolone derivatives. These compounds represent key pharmacophores and essential intermediates in the development of various drugs. Notably, the same reaction system is crucial to obtain Ivacaftor, a commercially available drug for managing cystic fibrosis (CF).<\/jats:p>","DOI":"10.1021\/acsomega.6c00867","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:35:41Z","timestamp":1783726541000},"page":"43255-43264","source":"Crossref","is-referenced-by-count":0,"title":["Sustainable Synthesis of Quinolones and the Main Based-Drug\nIvacaftor by\n                    <i>Aquoline<\/i>"],"prefix":"10.1021","volume":"11","author":[{"given":"Marialaura","family":"Frisina","sequence":"first","affiliation":[{"name":"Magna Graecia University , , ,","place":["Germaneto, Catanzaro, Italy, 88100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Scarpelli","sequence":"additional","affiliation":[{"name":"Magna Graecia University , , ,","place":["Germaneto, Catanzaro, Italy, 88100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"De Luca","sequence":"additional","affiliation":[{"name":"University of Calabria , , Arcavacata di Rende , ,","place":["Rende, Cosenza, Italy, 87036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Gualtieri","sequence":"additional","affiliation":[{"name":"Magna Graecia University , , ,","place":["Germaneto, Catanzaro, Italy, 88100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6617-9320","authenticated-orcid":true,"given":"Monica","family":"Nardi","sequence":"additional","affiliation":[{"name":"Magna Graecia University , , ,","place":["Germaneto, Catanzaro, Italy, 88100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0225-033X","authenticated-orcid":true,"given":"Antonio","family":"Procopio","sequence":"additional","affiliation":[{"name":"Magna Graecia University , , ,","place":["Germaneto, Catanzaro, Italy, 88100"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"2026072810070258500_cit1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S0891-5520(05)70260-9","article-title":"Fluoroquinolones","volume":"14","author":"O\u2019Donnell","year":"2000","journal-title":"Infect. Dis.\nClin. North Am."},{"issue":"174","key":"2026072810070258500_cit2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejmech.2019.04.033","article-title":"1,2,4-Triazole-quinoline\/quinolone\nhybrids as potential anti-bacterial agents","volume":"174","author":"Zhang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"2026072810070258500_cit3","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.ejmech.2017.09.050","article-title":"4-Quinolone hybrids\nand their antibacterial activities","volume":"141","author":"Hu","year":"2017","journal-title":"Eur. J.\nMed. Chem."},{"issue":"1","key":"2026072810070258500_cit4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1021\/co1000103","article-title":"Metal-Free\nIntramolecular Amination: One-Pot Tandem Synthesis of 3-Substituted\n4-Quinolones","volume":"13","author":"Qi-Lun","year":"2011","journal-title":"ACS Comb. Sci."},{"issue":"16","key":"2026072810070258500_cit5","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1016\/S0960-894X(00)00354-1","article-title":"Synthesis and evaluation\nof quinoline carboxyguanidines as antidiabetic agents","volume":"10","author":"Edmont","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"17","key":"2026072810070258500_cit6","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1016\/S0960-894X(03)00624-3","article-title":"Antitumor\nagents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone\nacetic acids and their esters","volume":"13","author":"Xia","year":"2003","journal-title":"Bioorg. Med.\nChem. Lett."},{"issue":"10","key":"2026072810070258500_cit7","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1039\/C9MD00120D","article-title":"Quinolone antibiotics","volume":"10","author":"Pham","year":"2019","journal-title":"Medchemcomm"},{"issue":"19","key":"2026072810070258500_cit8","doi-asserted-by":"publisher","first-page":"7076","DOI":"10.1021\/jm1007903","article-title":"Endochin Optimization:\nStructure\u2013Activity and\nStructure\u2013Property Relationship Studies of 3-Substituted 2-Methyl-4(1H)-quinolones\nwith Antimalarial Activity","volume":"53","author":"Cross","year":"2010","journal-title":"J. Med. Chem."},{"key":"2026072810070258500_cit9","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1096\/fasebj.4.10.2197151","article-title":"Cystic\nfibrosis: a disease in electrolyte tran sport","volume":"4","author":"Quinton","year":"1990","journal-title":"FASEB J."},{"issue":"5","key":"2026072810070258500_cit10","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.jcf.2014.02.004","article-title":"Antibacterial properties of the CFTR\npotentiator ivacaftor","volume":"13","author":"Reznikov","year":"2014","journal-title":"J. CystFibros"},{"issue":"2","key":"2026072810070258500_cit11","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1177\/1945892418815615","article-title":"a Cystic Fibrosis Transmembrane Conductance\nRegulator Potentiator, Enhances Ciprofloxacin Activity Against Pseudomonas\naeruginosa","volume":"33","author":"Cho","year":"2019","journal-title":"Am. J. RhinolAllergy"},{"key":"2026072810070258500_cit12","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1111\/jcpt.12722","article-title":"Does ivacaftor interfere\nwith the antimicrobial activity of commonly used antibiotics against\nPseudomonas aeruginosa? Results of an in vitro study","volume":"43","author":"Millar","year":"2018","journal-title":"J. ClinPharmTher"},{"key":"2026072810070258500_cit13","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.ijantimicag.2017.03.020","article-title":"Repurposing\nIvacaftor for treatment of Staphylococcus aureus infections","volume":"50","author":"Thakare","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"2026072810070258500_cit14","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.ijantimicag.2017.04.014","article-title":"Activity\nof innate antimicrobial\npeptides and ivacaftor against clinical cystic fibrosis respiratory\npathogens","volume":"50","author":"Payne","year":"2017","journal-title":"Int. J. Antimicrob. Agents"},{"key":"2026072810070258500_cit15","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1021\/acsinfecdis.6b00035","article-title":"An \u201cUnlikely\u201d Pair: The Antimicrobial\nSynergy of Polymyxin B in Combination with the Cystic Fibrosis Transmembrane\nConductance Regulator Drugs KALYDECO and ORKAMBI","volume":"2","author":"Schneider","year":"2016","journal-title":"ACS InfectDis"},{"issue":"2","key":"2026072810070258500_cit16","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1124\/mol.118.112177","article-title":"Lipophilicity\nof the Cystic Fibrosis Drug, Ivacaftor (VX-770), and Its Destabilizing\nEffect on the Major CF-causing Mutation: F508del","volume":"94","author":"Chin","year":"2018","journal-title":"Mol. Pharmacol."},{"issue":"48","key":"2026072810070258500_cit17","doi-asserted-by":"publisher","first-page":"45606","DOI":"10.1021\/acsomega.3c05839","article-title":"Synthesis and Evaluation of Ivacaftor\nDerivatives with Reduced Lipophilicity","volume":"8","author":"Iazzi","year":"2023","journal-title":"ACS\nOmega"},{"key":"2026072810070258500_cit18","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/9783527629688","volume-title":"Future trends for\ngreen chemistry in the pharmaceutical industry","author":"Dunn","year":"2010"},{"key":"2026072810070258500_cit19","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1039\/B918763B","article-title":"Green chemistry: principles and practice","volume":"39","author":"Anastas","year":"2010","journal-title":"Chem. Soc. Rev."},{"issue":"5","key":"2026072810070258500_cit20","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1016\/j.matpr.2021.06.458","article-title":"Green solvents:\nA suitable alternative for sustainable chemistry","volume":"47","author":"Nanda","year":"2021","journal-title":"Mater. Today: Proc."},{"key":"2026072810070258500_cit21","unstructured":"Van, G. F.\n          \n          Use of (n-\n[2, 4 -bis (1, 1 -dimethylethyl)-5-hydroxyphenyl]-1, 4-dihydro-4-oxoquinoline-3-ca\nrboxamide) for treating cftr mediated diseases. WO 2013067410\nA1, 2013."},{"key":"2026072810070258500_cit22","doi-asserted-by":"publisher","first-page":"2890","DOI":"10.1021\/ja01265a088","article-title":"The synthesis of certain substituted quinolines and\n5, 6-benzoquinolines","volume":"61","author":"Gould","year":"1939","journal-title":"J. Am. Chem. Soc."},{"key":"2026072810070258500_cit23","doi-asserted-by":"publisher","first-page":"4276","DOI":"10.1021\/jo070181o","article-title":"A mild\nand efficient synthesis of 4-quinolones and quinolone heterocycles","volume":"72","author":"Zewge","year":"2007","journal-title":"J. Org. Chem."},{"key":"2026072810070258500_cit24","unstructured":"Suresh, T.; Rao, D. V.; Ramanjaneyulu, G. S.; Satyanarayana, C.\n          A process for\nthe preparation of ivacaftor and its intermediates. WO\n2014125506 A2, 2014."},{"key":"2026072810070258500_cit25","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.3987\/COM-14-12933","article-title":"Expeditious Synthesis\nof Ivacaftor","volume":"89","author":"Shen","year":"2014","journal-title":"Heterocycles"},{"key":"2026072810070258500_cit26","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.tetlet.2004.12.046","article-title":"Novel and Convenient Synthesis of\n4(1H) Quinolines","volume":"46","author":"Tois","year":"2005","journal-title":"Tetrahedron Lett."},{"key":"2026072810070258500_cit27","doi-asserted-by":"publisher","first-page":"7433","DOI":"10.1002\/ejoc.201501048","article-title":"Breaking and Making\nof Rings: A Method\nfor the Preparation of 4-Quinolone-3-carb-oxylic Acid Amides and the\nExpensive Drug Ivacaftor","volume":"2015","author":"Vasudevan","year":"2015","journal-title":"Eur. J. Org. Chem."},{"key":"2026072810070258500_cit28","unstructured":"Reddy, D. S.; Natarajan, V.; Jachak, G. R.\n          Process for\nthe synthesis of ivacaftor and related compounds. WO 2016181414\nA1, 2016."},{"key":"2026072810070258500_cit29","unstructured":"Reddy, D. S.; Kulkarni, A. A.; Natarajan, V.; Sharma, M. J.\n          An improved\nprocess for the synthesis of ivacaftor. WO 2017208253\nA3, 2017."},{"key":"2026072810070258500_cit30","doi-asserted-by":"publisher","first-page":"5755","DOI":"10.1039\/D2GC01689C","article-title":"Practical\nsynthesis of quinolone drugs via anovel TsCl-mediated domino reaction\nsequence","volume":"24","author":"Lei","year":"2022","journal-title":"Green Chem."},{"key":"2026072810070258500_cit31","doi-asserted-by":"publisher","first-page":"100097","DOI":"10.1016\/j.scca.2025.100097","article-title":"Modification of Some Steps in the Synthesis of Ivacaftor\nby a Mechano-Chemical Approach","volume":"7","author":"Bankar","year":"2025","journal-title":"Sustain. Chem.\nClimate Action"},{"key":"2026072810070258500_cit32","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1039\/b820417a","article-title":"General MW-assisted\ngrafting of MCM-41: study of the dependence on time dielectric heating\nand solvent","volume":"11","author":"Procopio","year":"2009","journal-title":"Green Chem."},{"issue":"49","key":"2026072810070258500_cit33","doi-asserted-by":"publisher","first-page":"8623","DOI":"10.1016\/j.tetlet.2007.10.038","article-title":"Simple and efficient MW-assisted cleavage of acetals\nand ketals in pure water","volume":"48","author":"Procopio","year":"2007","journal-title":"Tetrahedron Lett."},{"issue":"7","key":"2026072810070258500_cit34","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.tet.2014.12.005","article-title":"Tetrahedron Lett.,\nEco-friendly stereoselective reduction of \u03b1","volume":"71","author":"Nardi","year":"2015","journal-title":"\u03b2-unsaturated carbonyl compounds by Er(OTf)3\/NaBH4 in 2-MeTHF"},{"key":"2026072810070258500_cit35","doi-asserted-by":"publisher","first-page":"4684","DOI":"10.1039\/C7FO01105A","article-title":"Synthesis and antioxidant\nevaluation\nof lipophilic oleuropein aglycone derivatives","volume":"8","author":"Nardi","year":"2017","journal-title":"Food Funct"},{"key":"2026072810070258500_cit36","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.3390\/molecules24193481","article-title":"Eco-friendly\nextraction and characterisation of nutraceuticals from olive leaves","volume":"24","author":"Benincasa","year":"2019","journal-title":"Molecules"},{"key":"2026072810070258500_cit37","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3390\/antiox9060513","article-title":"Natural Deep Eutectic\nSolvent as Extraction Media for the Main Phenolic\nCompounds from Olive Oil Processing Wastes","volume":"9","author":"Bonacci","year":"2020","journal-title":"Antioxidants"},{"issue":"1","key":"2026072810070258500_cit38","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3390\/antiox13010062","article-title":"Alternative Assisted\nExtraction Methods of Phenolic Compounds Using NaDESs","volume":"13","author":"Coscarella","year":"2024","journal-title":"Antioxidants"},{"key":"2026072810070258500_cit39","doi-asserted-by":"publisher","first-page":"5403","DOI":"10.1039\/C7GC02303K","article-title":"Water excellent\nsolvent for the synthesis\nof bifunctionalized cyclopentenones from furfural","volume":"19","author":"Nardi","year":"2017","journal-title":"Green Chem."},{"issue":"16","key":"2026072810070258500_cit40","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.3390\/molecules24162885","article-title":"Green Synthesis of Privileged Benzimidazole\nScaffolds Using Active Deep Eutectic Solvent","volume":"24","author":"Di Gioia","year":"2019","journal-title":"Molecules"},{"key":"2026072810070258500_cit41","doi-asserted-by":"publisher","first-page":"3208","DOI":"10.1039\/D3GC00118K","article-title":"Amine protection by in situ formation\nof choline chloride-based deep eutectic solvents","volume":"25","author":"Nardi","year":"2023","journal-title":"Green Chem."},{"key":"2026072810070258500_cit42","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1021\/je060038c","article-title":"Solubility\nof Metal Oxides in Deep Eutectic Solvents Based on Choline Chloride","volume":"51","author":"Abbott","year":"2006","journal-title":"J. Chem. Eng. Data"},{"key":"2026072810070258500_cit43","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1039\/B210714G","article-title":"Novel solvent\nproperties of choline chloride\/urea mixtures","volume":"1","author":"Abbott","year":"2003","journal-title":"ChemComm"},{"issue":"4","key":"2026072810070258500_cit44","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1104\/pp.111.178426","article-title":"Are natural\ndeep eutectic solvents the missing link in understanding cellular\nmetabolism and physiology?","volume":"156","author":"Verberne","year":"2011","journal-title":"Plant Physiol"},{"issue":"11","key":"2026072810070258500_cit45","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1021\/np400051w","article-title":"Ionic liquids and\ndeep eutectic solvents in natural\nproducts research: mixtures of solids as extraction solvents","volume":"76","author":"Dai","year":"2013","journal-title":"J. Nat. Prod."},{"key":"2026072810070258500_cit46","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1021\/np400051w","article-title":"Ionic liquids and deep eutectic solvents in natural\nproducts research: mixtures of solids as extraction solvents","volume":"76","author":"Dai","year":"2013","journal-title":"Anal. Chim. Acta"},{"key":"2026072810070258500_cit47","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.molliq.2016.01.038","article-title":"Properties\nand thermal behavior of natural deep eutectic\nsolvents","volume":"215","author":"Craveiro","year":"2016","journal-title":"J. Mol. Liq."},{"issue":"5","key":"2026072810070258500_cit48","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1021\/sc500096j","article-title":"Natural Deep Eutectic Solvents \u2013\nSolvents for\nthe 21st Century","volume":"2","author":"Paiva","year":"2014","journal-title":"ACS Sustainable Chem. Eng."},{"issue":"48","key":"2026072810070258500_cit49","doi-asserted-by":"publisher","first-page":"13212","DOI":"10.1021\/acs.jpcb.1c06636","article-title":"In Silico\nElucidation of Molecular\nPicture of Water\u2013Choline Chloride Mixture","volume":"125","author":"Sarkar","year":"2021","journal-title":"J. Phys. Chem. B"},{"issue":"41","key":"2026072810070258500_cit50","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202200566","article-title":"Neutron\nDiffraction\nStudy of Indole Solvation in Deep Eutectic Systems of Choline Chloride,\nMalic Acid, and Water","volume":"28","author":"Hammond","year":"2022","journal-title":"Chem\u2500Eur. J."},{"key":"2026072810070258500_cit51","doi-asserted-by":"publisher","first-page":"5471","DOI":"10.1021\/jm070387h","article-title":"Pharmacomodulations\naround the 4-oxo-1, 4-dihydroquinoline-3-carboxamides,\na class of potent CB2-selective cannabinoid receptor ligands: consequences\nin receptor affinity and functionality","volume":"50","author":"Stern","year":"2007","journal-title":"J. Med.\nChem."},{"key":"2026072810070258500_cit52","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1002\/(SICI)1097-458X(199611)34:11&lt;972::AID-OMR994&gt;3.0.CO;2-9","article-title":"An NMR Study\nof Halogenated 1, 4-Dihydro-1-ethyl-4-oxoquinoline-3-carboxylates","volume":"34","author":"Poda\u0300nyi","year":"1996","journal-title":"Magn. Reson. Chem."},{"key":"2026072810070258500_cit53","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.ejmech.2017.09.017","article-title":"structure-activity\nrelationships and preliminary mechanism of action of novel water-soluble\n4-quinolone-3-carboxamides as antiproliferative agents","volume":"140","author":"Zhang","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"6","key":"2026072810070258500_cit54","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1021\/acsmedchemlett.2c00067","article-title":"Drug-like\ninhibitors of DC-SIGN based on a quinolone\nscaffold","volume":"13","author":"Zhang","year":"2022","journal-title":"ACS Med. Chem. Lett."},{"issue":"7","key":"2026072810070258500_cit55","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1016\/j.bmc.2010.02.013","article-title":"Synthesis and structure-activity\nrelationships of antimalarial 4-oxo-3-carboxyl quinolones","volume":"18","author":"Zhang","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"10","key":"2026072810070258500_cit56","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1134\/S1070363222100280","article-title":"Design,\nSynthesis,\nSAR, Pharmacokinetic Prediction of New 4-Quinolones as Anti-Microbial\nAgents","volume":"92","author":"Dubal","year":"2022","journal-title":"Russ.J.Gen.Chem."},{"key":"2026072810070258500_cit57","doi-asserted-by":"publisher","first-page":"9776","DOI":"10.1021\/jm5012808","article-title":"Discovery\nof N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide\n(VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator","volume":"57","author":"Hadida","year":"2014","journal-title":"J. Med. Chem."},{"key":"2026072810070258500_cit58","doi-asserted-by":"publisher","first-page":"11668","DOI":"10.1021\/acssuschemeng.3c03461","article-title":"New insights\non choline chloride role in synthesis:\nThe case of direct amidation","volume":"11","author":"Romano","year":"2023","journal-title":"ACS SustainableChem.\nEng."},{"issue":"50","key":"2026072810070258500_cit59","doi-asserted-by":"publisher","first-page":"27841","DOI":"10.1021\/acs.jafc.4c09446","article-title":"Selective\nLipophilization of Natural\nPhenolic Alcohols Induced by In Situ Choline Chloride-Based Natural\nDeep Eutectic Solvents","volume":"72","author":"Bonacci","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"2026072810070258500_cit60","doi-asserted-by":"publisher","first-page":"115750","DOI":"10.1016\/j.molliq.2021.115750","article-title":"Liquid structure\nof a choline chloride-water natural deep eutectic solvent: A molecular\ndynamics characterization","volume":"331","author":"Triolo","year":"2021","journal-title":"J. Mol. Liq."},{"key":"2026072810070258500_cit61","doi-asserted-by":"publisher","first-page":"8395","DOI":"10.1039\/d0ob01516d","article-title":"Deep eutectic solvent\nas solvent and catalyst: one-pot synthesis of 1,3-dinitropropanes\nvia tandem Henry reaction\/Michael addition","volume":"18","author":"Colombo Dugoni","year":"2020","journal-title":"Org. Biomol. Chem."},{"key":"2026072810070258500_cit62","doi-asserted-by":"publisher","first-page":"103291","DOI":"10.1016\/j.bioorg.2019.103291","article-title":"Recent advances in\nthe synthetic and medicinal perspective of quinolones: A review","volume":"92","author":"Dhiman","year":"2019","journal-title":"Bioorg. Chem."},{"key":"2026072810070258500_cit63","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1007\/s10661-012-2717-7","article-title":"Monitoring\nof aminophenol isomers\nin surface water samples using a new HPLC method","volume":"185","author":"Badea","year":"2013","journal-title":"EnvironMonitAssess"},{"key":"2026072810070258500_cit64","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1007\/s00044-016-1631-x","article-title":"Novel quinolone-3-carboxylic\nacid derivatives as anti-HIV-1 agents: design, synthesis, and biological\nactivities","volume":"25","author":"Hajimahdi","year":"2016","journal-title":"MedChem. Res."},{"key":"2026072810070258500_cit65","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1021\/op049803n","article-title":"Unification\nof Reaction Metrics for Green Chemistry: Applications to Reaction\nAnalysis","volume":"9","author":"Andraos","year":"2005","journal-title":"Org. Proc. Res. Develop."},{"issue":"4","key":"2026072810070258500_cit66","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.2903\/j.efsa.2011.2145","article-title":"Scientific\nOpinion on the Safety and Efficacy of Choline Chloride as a Feed Additive\nfor All Animal Species","volume":"9","author":"European Food Safety Authority.","year":"2011","journal-title":"EFSA J."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c00867","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/29\/43255\/65880173\/acsomega.6c00867.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/29\/43255\/65880173\/acsomega.6c00867.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:43:15Z","timestamp":1785249795000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/11\/29\/43255\/5206818\/Sustainable-Synthesis-of-Quinolones-and-the-Main"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":66,"journal-issue":{"issue":"29","published-online":{"date-parts":[[2026,7,10]]},"published-print":{"date-parts":[[2026,7,28]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c00867","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]}}}