{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:12:08Z","timestamp":1790093528743,"version":"4.0.1"},"reference-count":76,"publisher":"American Chemical Society (ACS)","issue":"37","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Based on the previously reported neuroprotective, neurochemical, and behavioral effects of syringic acid, the present study was designed to investigate its antinociceptive and anti-inflammatory potential and to elucidate its possible mechanisms of action using in vitro and in silico methods. The antinociceptive effects of syringic acid were evaluated using the tail-clip, tail-immersion, hot-plate, formalin, and acetic acid-induced writhing tests in Balb\/c mice, whereas its anti-inflammatory activity was assessed using the carrageenan-induced paw edema model in Sprague-Dawley rats. Motor performance was examined using the activity meter and Rota-rod tests. The potential ulcerogenic effect was also evaluated. Syringic acid (50 and 100 mg\/kg, p.o.) did not significantly alter motor performance. It also did not alter nociceptive response parameters in the tail-clip, tail-immersion, or hot-plate tests. However, it significantly decreased writhing behavior in the writhing test and reduced paw-licking time during the second phase of the formalin test. Moreover, syringic acid attenuated carrageenan-induced paw edema. These findings indicate that syringic acid exerts peripheral antinociceptive and anti-inflammatory activities. In addition, acute administration of syringic acid did not induce gastric ulceration in mice. Enzyme inhibition studies showed that syringic acid inhibited cyclooxygenase-2 and 5-lipoxygenase at \u03bcM concentrations. In silico studies further revealed stable interactions between syringic acid and both enzymes.<\/jats:p>","DOI":"10.1021\/acsomega.6c00914","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:01:24Z","timestamp":1789052484000},"page":"54974-54990","source":"Crossref","is-referenced-by-count":0,"title":["Antinociceptive and Anti-Inflammatory Effects of Syringic\nAcid:\n                    <i>In Vivo<\/i>\n                    Evidence and\n                    <i>In Silico<\/i>\n                    Mechanistic Insights"],"prefix":"10.1021","volume":"11","author":[{"given":"S\u0327eyda","family":"Yo\u0308n","sequence":"first","affiliation":[{"name":"Anadolu University , , ,","place":["Eskis\u0327ehir, Tu\u0308rkiye, 26470"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0527-7757","authenticated-orcid":true,"given":"Cevs\u0327en","family":"Yaz\u0131c\u0131 S\u0327enocak","sequence":"additional","affiliation":[{"name":"Anadolu University , , ,","place":["Eskis\u0327ehir, Tu\u0308rkiye, 26470"]},{"name":"Anadolu University , , ,","place":["Eskis\u0327ehir, Tu\u0308rkiye, 26470"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5623-3913","authenticated-orcid":true,"given":"Gizem","family":"Tu\u0308rkog\u0306lu Sag\u0306l\u0131k","sequence":"additional","affiliation":[{"name":"Anadolu University , , ,","place":["Eskis\u0327ehir, Tu\u0308rkiye, 26470"]},{"name":"Anadolu University , , ,","place":["Eskis\u0327ehir, Tu\u0308rkiye, 26470"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3314-1961","authenticated-orcid":true,"given":"U\u0308mmu\u0308han","family":"Kandemir","sequence":"additional","affiliation":[{"name":"Bilecik S\u0327eyh Edebali University , , ,","place":["Bilecik, Tu\u0308rkiye, 11100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Eser","sequence":"additional","affiliation":[{"name":"Anadolu University , , ,","place":["Eskis\u0327ehir, Tu\u0308rkiye, 26470"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8651-826X","authenticated-orcid":true,"given":"Asaf Evrim","family":"Evren","sequence":"additional","affiliation":[{"name":"Anadolu University , , ,","place":["Eskis\u0327ehir, Tu\u0308rkiye, 26470"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O\u0308zgu\u0308r Devrim","family":"Can","sequence":"additional","affiliation":[{"name":"Anadolu University , , ,","place":["Eskis\u0327ehir, Tu\u0308rkiye, 26470"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-4266","authenticated-orcid":true,"given":"U\u0308mide","family":"Demir O\u0308zkay","sequence":"additional","affiliation":[{"name":"Anadolu University , , ,","place":["Eskis\u0327ehir, Tu\u0308rkiye, 26470"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"2026092210565311300_cit1","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.biopha.2018.09.069","article-title":"Syringic\nacid (SA)\u2013a review of its occurrence, biosynthesis, pharmacological\nand industrial importance","volume":"108","author":"Srinivasulu","year":"2018","journal-title":"Biomed. 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Pharmacol."},{"issue":"3","key":"2026092210565311300_cit6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.4103\/2221-1691.276317","article-title":"Syringic acid improves oxidative\nstress and mitochondrial biogenesis in the liver of streptozotocin-induced\ndiabetic rats","volume":"10","author":"Sabahi","year":"2020","journal-title":"Asian Pac. J. Trop. Biomed."},{"issue":"3","key":"2026092210565311300_cit7","doi-asserted-by":"publisher","first-page":"405","DOI":"10.2174\/1570163817666200211101228","article-title":"Syringic acid: a potential natural\ncompound for the\nmanagement of renal oxidative stress and mitochondrial biogenesis\nin diabetic rats","volume":"18","author":"Rashedinia","year":"2021","journal-title":"Curr. 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