{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:52:29Z","timestamp":1785851549935,"version":"3.56.0"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"30","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","award":["BRF1-018\/2565"],"award-info":[{"award-number":["BRF1-018\/2565"]}],"id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","award":["MRCMGR 01\/2564"],"award-info":[{"award-number":["MRCMGR 01\/2564"]}],"id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Faculty of Medicine Ramathibodi Hospital, Mahidol University","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Particulate matter (PM) is a global air pollutant causing respiratory pathology and systemic effects through bloodstream distribution, including placental transfer that potentially disrupts fetal development. Zebrafish, with rapid development and 82% orthology to human genes, provide an excellent model for studying the developing embryo. This study investigated the effects of PM2.5 and PM10 at 500 and 1000 \u03bcg\/mL during embryogenesis (4\u201350 h postfertilization). PM2.5 exposure uniquely caused a 22 h hatching delay, suggesting developmental disruption. Untargeted metabolomics via LC-MS\/MS was employed to investigate underlying mechanisms. Principal component analysis revealed distinct clustering by concentration (PC1, PC2) and particle size (PC1, PC3). Volcano plot analysis identified more altered metabolites (&amp;gt;2-fold change, p &amp;lt; 0.05) in PM2.5 versus PM10 at both concentrations. Pathway analysis demonstrated PM2.5 significantly disrupted pantothenate\/CoA, retinol, and riboflavin metabolism, indicating these pathways mediate PM2.5-induced effects on embryonic development. At 1000 \u03bcg\/mL, riboflavin significantly decreased in PM2.5 versus PM10 groups. Glutathione metabolism showed differential responses: reduced glutathione was depleted in PM2.5 but increased in PM10-exposed embryos, suggesting particle size-dependent oxidative stress responses. These findings demonstrate PM2.5 more potently disrupts embryonic metabolic pathways than PM10, potentially informing prevention strategies, including vitamin supplementation for PM-related developmental abnormalities.<\/jats:p>","DOI":"10.1021\/acsomega.6c00972","type":"journal-article","created":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T17:52:17Z","timestamp":1784483537000},"page":"44748-44760","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic Profiling\nReveals PM2.5- and PM10-Induced\nVitamin and Oxidative Stress Pathway Alterations Associated with Developmental\nToxicity in Zebrafish Embryos"],"prefix":"10.1021","volume":"11","author":[{"given":"Chamnan","family":"Yibcharoenporn","sequence":"first","affiliation":[{"name":"Mahidol University , , , ,","place":["Bang Phli, Samut Prakarn, Thailand, 10540"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanon","family":"Jakakul","sequence":"additional","affiliation":[{"name":"Mahidol University , , , ,","place":["Bang Phli, Samut Prakarn, Thailand, 10540"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng Chieh","family":"Yang","sequence":"additional","affiliation":[{"name":"Mahidol University , , ,","place":["Bangkok, Thailand, 10400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theerachat","family":"Kampaengsri","sequence":"additional","affiliation":[{"name":"Mahidol University , , , ,","place":["Bang Phli, Samut Prakarn, Thailand, 10540"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4428-4140","authenticated-orcid":true,"given":"Sucheewin","family":"Krobthong","sequence":"additional","affiliation":[{"name":"Mahidol University , , ,","place":["Bangkok, Thailand, 10400"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinnakarn","family":"Techapichetvanich","sequence":"additional","affiliation":[{"name":"Mahidol University , , , ,","place":["Bang Phli, Samut Prakarn, Thailand, 10540"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apisada","family":"Jiso","sequence":"additional","affiliation":[{"name":"Chiang Mai University , , ,","place":["Chiang Mai, Thailand, 50200"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwapech","family":"Sillapaprayoon","sequence":"additional","affiliation":[{"name":"National Science and Technology Development Agency (NSTDA) , , , ,","place":["Khlong Luang, Pathum Thani, Thailand, 12120"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phisit","family":"Khemawoot","sequence":"additional","affiliation":[{"name":"Mahidol University , , , ,","place":["Bang Phli, Samut Prakarn, Thailand, 10540"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6528-7346","authenticated-orcid":true,"given":"Arnatchai","family":"Maiuthed","sequence":"additional","affiliation":[{"name":"Mahidol University , , ,","place":["Bangkok, Thailand, 10400"]},{"name":"Mahidol University , , ,","place":["Bangkok, Thailand, 10400"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,19]]},"reference":[{"issue":"21","key":"2026080409252270200_cit1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192114281","article-title":"Chemical Composition, Sources, and Health Risk Assessment\nof PM(2.5) and PM(10) in Urban Sites of Bangkok, Thailand","volume":"19","author":"Ahmad","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"2026080409252270200_cit2","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.envint.2014.10.005","article-title":"A review on\nthe human health impact\nof airborne particulate matter","volume":"74","author":"Kim","year":"2015","journal-title":"Environ. Int."},{"key":"2026080409252270200_cit3","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00091","article-title":"The Impact\nof PM(2.5) on the Host Defense of Respiratory\nSystem","volume":"8","author":"Yang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"12","key":"2026080409252270200_cit4","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19127511","article-title":"Recent\nInsights into Particulate\nMatter (PM(2.5))-Mediated Toxicity in Humans: An Overview","volume":"19","author":"Thangavel","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"6","key":"2026080409252270200_cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.101670","article-title":"PM2.5 and\nCardiovascular Health Risks","volume":"48","author":"Krittanawong","year":"2023","journal-title":"Curr. Probl. Cardiol."},{"issue":"1","key":"2026080409252270200_cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11654-3","article-title":"Ambient black carbon particles reach\nthe fetal side of human placenta","volume":"10","author":"Bove\u0301","year":"2019","journal-title":"Nat. Commun."},{"issue":"7","key":"2026080409252270200_cit7","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1242\/dmm.015545","article-title":"Zebrafish models in translational research: tipping\nthe scales toward advancements in human health","volume":"7","author":"Phillips","year":"2014","journal-title":"Dis. Models Mech."},{"key":"2026080409252270200_cit8","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.chemosphere.2017.04.013","article-title":"Multi-organ toxicity induced by fine particulate matter PM(2.5) in\nzebrafish (Danio rerio) model","volume":"180","author":"Duan","year":"2017","journal-title":"Chemosphere"},{"key":"2026080409252270200_cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.123841","article-title":"Short-term exposure to fine particulate\nmatter exposure\nimpairs innate immune and inflammatory responses to a pathogen stimulus:\nA functional study in the zebrafish model","volume":"348","author":"Cafora","year":"2024","journal-title":"Environ.\nPollut."},{"issue":"10","key":"2026080409252270200_cit10","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1002\/jat.4325","article-title":"Impact of\nairborne total suspended particles (TSP) and fine particulate\nmatter (PM(2.5))-induced developmental toxicity in zebrafish (Danio rerio) embryos","volume":"42","author":"Jia","year":"2022","journal-title":"J. Appl.\nToxicol."},{"key":"2026080409252270200_cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.126288","article-title":"Particulate\nmatter (PM10) induces cardiovascular developmental toxicity in zebrafish\nembryos and larvae via the ERS, Nrf2 and Wnt pathways","volume":"250","author":"Cen","year":"2020","journal-title":"Chemosphere"},{"key":"2026080409252270200_cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2021.105928","article-title":"Developmental\ntoxicity induced by particulate matter (PM(2.5)) in zebrafish (Danio rerio) model","volume":"238","author":"Manjunatha","year":"2021","journal-title":"Aquat.\nToxicol."},{"key":"2026080409252270200_cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114839","article-title":"Perturbation of arachidonic\nacid and glycerolipid metabolism promoted particulate matter-induced\ninflammatory responses in human bronchial epithelial cells","volume":"256","author":"Wang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"2026080409252270200_cit14","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1016\/j.scitotenv.2019.07.192","article-title":"Comprehensive\nmetabolic responses\nof HepG2 cells to fine particulate matter exposure: Insights from\nan untargeted metabolomics","volume":"691","author":"Ye","year":"2019","journal-title":"Sci. Total Environ."},{"issue":"11","key":"2026080409252270200_cit15","doi-asserted-by":"publisher","DOI":"10.3390\/toxics10110632","article-title":"Phenotypic and Metabolomic\nCharacterization of 3D Lung Cell Cultures\nExposed to Airborne Particulate Matter from Three Air Quality Network\nStations in Catalonia","volume":"10","author":"Villasclaras","year":"2022","journal-title":"Toxics"},{"key":"2026080409252270200_cit16","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1069906","article-title":"Outdoor particulate\nmatter exposure affects metabolome in chronic obstructive pulmonary\ndisease: Preliminary study","volume":"11","author":"Yu","year":"2023","journal-title":"Front. Public Health"},{"issue":"11","key":"2026080409252270200_cit17","doi-asserted-by":"publisher","first-page":"7350","DOI":"10.1021\/acs.est.1c04915","article-title":"The Oxidative Potential\nof Fine Particulate Matter and Biological Perturbations in Human Plasma\nand Saliva Metabolome","volume":"56","author":"Tang","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"2026080409252270200_cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2022.119308","article-title":"Potential urinary biomarkers in young adults with short-term\nexposure to particulate matter and bioaerosols identified using an\nunbiased metabolomic approach","volume":"305","author":"Li","year":"2022","journal-title":"Environ. Pollut."},{"issue":"5","key":"2026080409252270200_cit19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213661","article-title":"Metabolic\nprofiling of zebrafish embryo development from blastula period to\nearly larval stages","volume":"14","author":"Dhillon","year":"2019","journal-title":"PLoS One"},{"key":"2026080409252270200_cit20","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.toxrep.2024.03.011","article-title":"Assessing\ndevelopmental and transcriptional effects of PM2.5 on zebrafish embryos","volume":"12","author":"Techapichetvanich","year":"2024","journal-title":"Toxicol. Rep."},{"key":"2026080409252270200_cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2026.104948","article-title":"Impact of environmental\nparticulates\non zebrafish embryo development and gene expression","volume":"122","author":"Techapichetvanich","year":"2026","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"5","key":"2026080409252270200_cit22","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10050732","article-title":"Particulate\nMatter, an Intrauterine\nToxin Affecting Foetal Development and Beyond","volume":"10","author":"Chen","year":"2021","journal-title":"Antioxidants"},{"issue":"10","key":"2026080409252270200_cit23","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1002\/jat.4325","article-title":"Impact of airborne total suspended particles (TSP) and fine particulate\nmatter (PM2.5)-induced developmental toxicity in zebrafish (Danio rerio) embryos","volume":"42","author":"Jia","year":"2022","journal-title":"J. Appl.\nToxicol."},{"issue":"1","key":"2026080409252270200_cit24","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-07496-z","article-title":"Zebrafishology, study design guidelines for rigorous\nand reproducible data using zebrafish","volume":"8","author":"Bedell","year":"2025","journal-title":"Commun.\nBiol."},{"issue":"7446","key":"2026080409252270200_cit25","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference\ngenome sequence and\nits relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"issue":"5","key":"2026080409252270200_cit26","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1203\/PDR.0b013e318186e609","article-title":"Zebrafish as a Developmental Model Organism for Pediatric Research","volume":"64","author":"Veldman","year":"2008","journal-title":"Pediatr. Res."},{"issue":"3","key":"2026080409252270200_cit27","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages\nof embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev.\nDyn."},{"key":"2026080409252270200_cit28","doi-asserted-by":"publisher","DOI":"10.1787\/9789264203709-en","article-title":"Test No. 236: Fish Embryo Acute Toxicity (FET) Test","volume-title":"OECD Guidelines for the Testing of Chemicals, Section\n2","year":"2025"},{"key":"2026080409252270200_cit29","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1488028","article-title":"Exposure to\nambient air pollutions and its association with adverse birth outcomes:\na systematic review and meta-analysis of epidemiological studies","volume":"12","author":"Desye","year":"2024","journal-title":"Front. Public Health"},{"issue":"8","key":"2026080409252270200_cit30","doi-asserted-by":"publisher","DOI":"10.3390\/toxics12080587","article-title":"Cross-Omics Analyses Reveal the Effects\nof Ambient PM(2.5) Exposure on Hepatic Metabolism in Female Mice","volume":"12","author":"Yan","year":"2024","journal-title":"Toxics"},{"key":"2026080409252270200_cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2025.104707","article-title":"Cytotoxic and metabolic effects of\norganic extracts from airborne fine particulate matter (PM(2.5)) in\nneuronal cells","volume":"116","author":"Silva","year":"2025","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"2026080409252270200_cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115200","article-title":"Effects of PM(2.5)\nand high-fat diet interaction on blood glucose metabolism in adolescent\nmale Wistar rats: A serum metabolomics analysis based on ultra-high\nperformance liquid chromatography\/mass spectrometry","volume":"262","author":"Li","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"2026080409252270200_cit33","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.bbrc.2011.07.056","article-title":"Glutathione is essential for early\nembryogenesis--analysis of a glutathione synthetase knockout mouse","volume":"412","author":"Winkler","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026080409252270200_cit34","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.freeradbiomed.2013.06.011","article-title":"Glutathione\nredox dynamics and expression of glutathione-related\ngenes in the developing embryo","volume":"65","author":"Timme-Laragy","year":"2013","journal-title":"Free Radic.\nBiol. Med."},{"key":"2026080409252270200_cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101788","article-title":"Modulating glutathione thiol status alters pancreatic\n\u03b2-cell morphogenesis in the developing zebrafish (Danio rerio) embryo","volume":"38","author":"Rastogi","year":"2021","journal-title":"Redox\nBiol."},{"issue":"3","key":"2026080409252270200_cit36","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1093\/hmg\/ddae171","article-title":"Development\nof a riboflavin-responsive\nmodel of riboflavin transporter deficiency in zebrafish","volume":"34","author":"Choueiri","year":"2025","journal-title":"Hum. Mol. Genet."},{"issue":"16","key":"2026080409252270200_cit37","doi-asserted-by":"publisher","first-page":"4257","DOI":"10.1007\/s00216-016-9519-7","article-title":"Development of two fine particulate matter\nstandard reference materials (&lt;4 \u03bcm and &lt; 10 \u03bcm)\nfor the determination of organic and inorganic constituents","volume":"408","author":"Schantz","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"2026080409252270200_cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2023.153466","article-title":"PM2.5 induces mitochondrial\ndysfunction via AHR-mediated cyp1a1 overexpression\nduring zebrafish heart development","volume":"487","author":"Chen","year":"2023","journal-title":"Toxicology"},{"issue":"5","key":"2026080409252270200_cit39","doi-asserted-by":"publisher","first-page":"591","DOI":"10.2174\/1570159X18666200729103529","article-title":"Tetrahydrobioterin\n(BH4) Pathway: From Metabolism to Neuropsychiatry","volume":"19","author":"Fanet","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"2026080409252270200_cit40","doi-asserted-by":"publisher","DOI":"10.1186\/1471-213X-12-12","article-title":"Disruption of the\nfolate pathway in zebrafish causes developmental defects","volume":"12","author":"Lee","year":"2012","journal-title":"BMC Dev Biol."},{"key":"2026080409252270200_cit41","doi-asserted-by":"publisher","DOI":"10.1038\/srep16093","article-title":"Folic acid protects\nagainst arsenic-mediated embryo toxicity by up-regulating the expression\nof Dvr1","volume":"5","author":"Ma","year":"2015","journal-title":"Sci. Rep."},{"issue":"10","key":"2026080409252270200_cit42","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1002\/tox.22448","article-title":"Protective\neffects of folic acid on PM2.5-induced cardiac developmental\ntoxicity in zebrafish embryos by targeting AhR and Wnt\/\u03b2-catenin\nsignal pathways","volume":"32","author":"Yue","year":"2017","journal-title":"Environ. Toxicol."},{"issue":"20","key":"2026080409252270200_cit43","doi-asserted-by":"publisher","first-page":"7302","DOI":"10.1073\/pnas.1319142111","article-title":"Identification\nof the 11-cis-specific retinyl-ester\nsynthase in retinal Mu\u0308ller cells as multifunctional O-acyltransferase\n(MFAT)","volume":"111","author":"Kaylor","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"2026080409252270200_cit44","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ijbiomac.2010.05.014","article-title":"Cleavage\nof the retinal pigment epithelium-specific protein RPE65 under oxidative\nstress","volume":"47","author":"Lee","year":"2010","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"2026080409252270200_cit45","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11041180","article-title":"Zebrafish as a Model\nto Study Retinoic Acid Signaling\nin Development and Disease","volume":"11","author":"Hawkins","year":"2023","journal-title":"Biomedicines"},{"key":"2026080409252270200_cit46","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.mod.2018.02.005","article-title":"Coordinate\nregulation of retinoic acid synthesis by pbx genes and fibroblast\ngrowth factor signaling by hoxb1b is required for hindbrain patterning\nand development","volume":"150","author":"Selland","year":"2018","journal-title":"Mech. Dev."},{"issue":"10","key":"2026080409252270200_cit47","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1371\/journal.pgen.0030189","article-title":"The cdx\ngenes and retinoic acid control\nthe positioning and segmentation of the zebrafish pronephros","volume":"3","author":"Wingert","year":"2007","journal-title":"PLoS Genet."},{"issue":"1","key":"2026080409252270200_cit48","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ydbio.2011.07.022","article-title":"Restraint of Fgf8 signaling by retinoic\nacid signaling\nis required for proper heart and forelimb formation","volume":"358","author":"Sorrell","year":"2011","journal-title":"Dev. Biol."},{"issue":"2","key":"2026080409252270200_cit49","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.advms.2023.10.004","article-title":"Ceramides\nand their roles in programmed cell death","volume":"68","author":"Pila\u0301tova\u0301","year":"2023","journal-title":"Adv.\nMed. Sci."},{"key":"2026080409252270200_cit50","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21992","article-title":"The ceramide synthase\n2b gene mediates genomic sensing and regulation of sphingosine levels\nduring zebrafish embryogenesis","volume":"6","author":"Mendelson","year":"2017","journal-title":"eLife"},{"key":"2026080409252270200_cit51","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.jad.2017.02.008","article-title":"Ceramides and depression: A systematic\nreview","volume":"213","author":"Dinoff","year":"2017","journal-title":"J. Affective Disord."},{"issue":"3","key":"2026080409252270200_cit52","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1172\/JCI124159","article-title":"DEGS1-associated\naberrant sphingolipid metabolism impairs\nnervous system function in humans","volume":"129","author":"Karsai","year":"2019","journal-title":"J. Clin.\nInvest"},{"key":"2026080409252270200_cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.175134","article-title":"Parental exposure to acrylamide disrupts sphingolipid\nmetabolism and impairs transgenerational neurodevelopment in zebrafish\n(Danio rerio) offspring","volume":"950","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"2026080409252270200_cit54","doi-asserted-by":"publisher","DOI":"10.1038\/srep37660","article-title":"Down-regulation\nof coasy, the gene\nassociated with NBIA-VI, reduces Bmp signaling, perturbs dorso-ventral\npatterning and alters neuronal development in zebrafish","volume":"6","author":"Khatri","year":"2016","journal-title":"Sci. Rep."},{"issue":"17","key":"2026080409252270200_cit55","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27175506","article-title":"In the Swim\nof Cannabis: Developmental Toxicity and Metabolomic Pathway Alterations\nof Zebrafish Larvae Exposed to THC for the Assessment of Its Potential\nEnvironmental and Human Health Impact","volume":"27","author":"Chatzimitakos","year":"2022","journal-title":"Molecules"},{"issue":"2","key":"2026080409252270200_cit56","doi-asserted-by":"publisher","DOI":"10.3390\/nano11020483","article-title":"Metabolomic\nProfiling Unveils the Impact of Non-Doped and Heteroatom-Doped Carbon\nNanodots on Zebrafish (Danio rerio)\nEmbryos","volume":"11","author":"T","year":"2021","journal-title":"Nanomaterials"},{"issue":"4","key":"2026080409252270200_cit57","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.cbpb.2011.07.005","article-title":"Effects\nof dietary biotin and avidin on growth, survival, feed conversion,\nbiotin status and gene expression of zebrafish Danio rerio","volume":"160","author":"Yossa","year":"2011","journal-title":"Comp. Biochem. Physiol.,\nPart B:Biochem. Mol. Biol."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c00972","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/30\/44748\/66030929\/acsomega.6c00972.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/30\/44748\/66030929\/acsomega.6c00972.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:25:51Z","timestamp":1785849951000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/11\/30\/44748\/5215585\/Metabolic-Profiling-Reveals-PM2-5-and-PM10-Induced"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,19]]},"references-count":57,"journal-issue":{"issue":"30","published-online":{"date-parts":[[2026,7,19]]},"published-print":{"date-parts":[[2026,8,4]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c00972","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,19]]}}}