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In this work, hydrothermally treated wood solids (T = 180 \u00b0C, t = 45 min, liquid-to-solid ratio = 1) were refluxed for 1 h using acetic acid, formic acid, and ethanol as solvent-reagents. In addition, Amberlyst 15 (Amb-15) was tested as a heterogeneous acid catalyst for REx. The design of the reaction setup allowed to minimize product losses, even when Amb-15 was used, which could be easily removed from the reaction mixture. The extracted lignins showed appreciable amounts of native linkages (28.8\u201346.4\/100 Ar), molar masses of 2.8\u201313.7 kDa (Mw), and total hydroxy group contents of 4.6\u20135.8 mmol\/g. HSQC NMR analysis proved the incorporation of ethoxy, acetyl, and formyl groups in the extracted lignins in 1.2\u20132.0\/100 Ar, 39.2\u201339.4\/100 Ar, and 12.6\u201315.4\/100 Ar, respectively. The molar masses of the residual cellulosic solids ranged from DPw of 2900 to 1000, and 13C NMR solid-state and solution-state NMR analyses confirmed the functionalization of the residual cellulosic solids as well, though to a low extent.<\/jats:p>","DOI":"10.1021\/acsomega.6c01031","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T02:45:20Z","timestamp":1784342720000},"page":"44826-44840","source":"Crossref","is-referenced-by-count":0,"title":["Simultaneous Lignin Fractionation and Functionalization\nunder Mild Conditions via Reactive Extraction"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4063-1256","authenticated-orcid":true,"given":"Davide","family":"Rigo","sequence":"first","affiliation":[{"name":"Aalto University , , Vuorimiehentie 1 , ,","place":["Espoo, Finland, 02150"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-4142","authenticated-orcid":true,"given":"Nadine","family":"Kohlhuber","sequence":"additional","affiliation":[{"name":"BOKU University , , Konrad-Lorenz-Strasse 24 , ,","place":["Tulln an der Donau, Austria, 3430"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Fliri","sequence":"additional","affiliation":[{"name":"Aalto University , , Vuorimiehentie 1 , ,","place":["Espoo, Finland, 02150"]},{"name":"BOKU University , , Konrad-Lorenz-Strasse 24 , ,","place":["Tulln an der Donau, Austria, 3430"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-804X","authenticated-orcid":true,"given":"Irina","family":"Sulaeva","sequence":"additional","affiliation":[{"name":"BOKU University , , Konrad-Lorenz-Strasse 24 , ,","place":["Tulln an der Donau, Austria, 3430"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryna","family":"Diment","sequence":"additional","affiliation":[{"name":"Aalto University , , Vuorimiehentie 1 , ,","place":["Espoo, Finland, 02150"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-1684","authenticated-orcid":true,"given":"Oliver","family":"Musl","sequence":"additional","affiliation":[{"name":"BOKU University , , Konrad-Lorenz-Strasse 24 , ,","place":["Tulln an der Donau, Austria, 3430"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1981-2271","authenticated-orcid":true,"given":"Antje","family":"Potthast","sequence":"additional","affiliation":[{"name":"BOKU University , , Konrad-Lorenz-Strasse 24 , ,","place":["Tulln an der Donau, Austria, 3430"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"issue":"4","key":"2026080409253432400_cit1","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1002\/cssc.202002553","article-title":"New Opportunities in the Valorization of Technical\nLignins","volume":"14","author":"Balakshin","year":"2021","journal-title":"ChemSusChem"},{"issue":"11","key":"2026080409253432400_cit2","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1002\/cssc.201000157","article-title":"Lignin as Renewable\nRaw Material","volume":"3","author":"Calvo-Flores","year":"2010","journal-title":"ChemSusChem"},{"key":"2026080409253432400_cit3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.13073\/FPJ-D-19-00038","article-title":"Pulping\nProcesses and Their Effects on Cellulose Fibers and Nanofibrillated\nCellulose Properties: A Review","volume":"70","author":"Iglesias","year":"2020","journal-title":"For. 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