{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:59:03Z","timestamp":1784951943373,"version":"3.55.0"},"reference-count":74,"publisher":"American Chemical Society (ACS)","issue":"13","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017170","name":"Thailand Science Research and Innovation","doi-asserted-by":"publisher","award":["HEA_FF_69_244_2300_055"],"award-info":[{"award-number":["HEA_FF_69_244_2300_055"]}],"id":[{"id":"10.13039\/501100017170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["HEA_FF_69_244_2300_055"],"award-info":[{"award-number":["HEA_FF_69_244_2300_055"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2026,4,7]]},"DOI":"10.1021\/acsomega.6c01048","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:14:07Z","timestamp":1774520047000},"page":"21321-21338","source":"Crossref","is-referenced-by-count":1,"title":["Structural and Dynamic Perturbations in the RyR1 Selectivity Filter Induced by Ala4893 Mutations: Implications for Malignant Hyperthermia and Myopathy"],"prefix":"10.1021","volume":"11","author":[{"given":"Panyakorn","family":"Taweechat","sequence":"first","affiliation":[{"name":"Center of Excellence in Computational Chemistry, Department of Chemistry, Faculty of Science","place":["Bangkok, Thailand"]},{"name":"Chulalongkorn University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panisak","family":"Boonamnaj","sequence":"additional","affiliation":[{"name":"Center of Excellence in Computational Chemistry, Department of Chemistry, Faculty of Science","place":["Bangkok, Thailand"]},{"name":"Chulalongkorn University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pisit","family":"Lerttanakij","sequence":"additional","affiliation":[{"name":"Center of Excellence in Computational Chemistry, Department of Chemistry, Faculty of Science","place":["Bangkok, Thailand"]},{"name":"Chulalongkorn University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8029-332X","authenticated-orcid":true,"given":"Pornthep","family":"Sompornpisut","sequence":"additional","affiliation":[{"name":"Center of Excellence in Computational Chemistry, Department of Chemistry, Faculty of Science","place":["Bangkok, Thailand"]},{"name":"Chulalongkorn University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3052"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201711878"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-2888-2_9"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100874"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.12.004"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1612441113"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1310571110"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01384-x"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20356"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.104.048447"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/ng0993-46"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/ng0993-51"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1996.76.2.537"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2004.08.001"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.04.089"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198632020-00003"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198204000-00005"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318232053e"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200606000-00008"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198910000-00015"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1997.tb04820.x"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/978-1-4613-2079-1_11","volume-title":"Malignant hyperthermia","author":"Kikuchi H.","year":"1987"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.4.83"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05626-5"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlaa104"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-010-0977-3"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1177\/0883073812436605"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-25"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000269792.63927.86"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.7554\/elife.75568"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2021.08.001"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.075"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/nature13916"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb938"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb2964"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2122140119"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4067"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6807-11-6"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/jp101759q"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/jp003020w"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20289"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1063\/1.467468"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/S0263-7855(97)00009-X"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2015.1032936"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112419"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/jz201501a"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c03018"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2012.173"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1063\/1.2829861"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48292-3"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1039\/B615319B"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/ct049977a"},{"key":"ref55\/cit55","unstructured":"Frisch, M.; Trucks, G.; Schlegel, H.; Scuseria, G.; Robb, M.; Cheeseman, J.; Scalmani, G.; Barone, V.; Petersson, G.; Nakatsuji, H.\n                      Gaussian 16\n                      , Revision C. 01; Gaussian Inc.: Wallingford CT, 2016."},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14573-w"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25061-z"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.92.1.1"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.104.056002"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(00)76339-9"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2014.04.023"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06787-1"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.88.159"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-011-9494-6"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep204"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl077"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.22.2581"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-8966(02)00218-3"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.25.2879"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071048198"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200308791"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040580"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707353200"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181d69283"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c01048","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c01048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:49:40Z","timestamp":1775551780000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.6c01048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":74,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,4,7]]}},"alternative-id":["10.1021\/acsomega.6c01048"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c01048","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]}}}