{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:46:41Z","timestamp":1782827201350,"version":"3.54.5"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"25","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017170","name":"Thailand Science Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017170","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["N42A670602"],"award-info":[{"award-number":["N42A670602"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013238","name":"Faculty of Medicine Siriraj Hospital, Mahidol University","doi-asserted-by":"publisher","award":["R016637001"],"award-info":[{"award-number":["R016637001"]}],"id":[{"id":"10.13039\/501100013238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2026,6,30]]},"DOI":"10.1021\/acsomega.6c01330","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T17:26:38Z","timestamp":1781544398000},"page":"37132-37144","source":"Crossref","is-referenced-by-count":0,"title":["Development of Surfactant-Modified Liposomal Lomustine to Improve Blood\u2013Brain Barrier Transport and Therapeutic Outcomes in Glioblastoma"],"prefix":"10.1021","volume":"11","author":[{"given":"Kamonlatth","family":"Rodponthukwaji","sequence":"first","affiliation":[{"name":"Siriraj Center of Research Excellence in Theranostic Nanomedicine, Research Department, Faculty of Medicine Siriraj Hospital","place":["Bangkok, Thailand"]},{"name":"Mahidol University","place":["Bangkok, Thailand"]},{"name":"Department of Biochemistry, Faculty of Medicine Siriraj Hospital","place":["Bangkok, Thailand"]},{"name":"Mahidol University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuda","family":"Kunwong","sequence":"additional","affiliation":[{"name":"Siriraj Center of Research Excellence in Theranostic Nanomedicine, Research Department, Faculty of Medicine Siriraj Hospital","place":["Bangkok, Thailand"]},{"name":"Mahidol University","place":["Bangkok, Thailand"]},{"name":"Department of Biochemistry, Faculty of Medicine Siriraj Hospital","place":["Bangkok, Thailand"]},{"name":"Mahidol University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pucharee","family":"Songprakhon","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital","place":["Bangkok, Thailand"]},{"name":"Mahidol University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sith","family":"Sathornsumetee","sequence":"additional","affiliation":[{"name":"Siriraj Center of Research Excellence in Theranostic Nanomedicine, Research Department, Faculty of Medicine Siriraj Hospital","place":["Bangkok, Thailand"]},{"name":"Mahidol University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chatchawan","family":"Srisawat","sequence":"additional","affiliation":[{"name":"Siriraj Center of Research Excellence in Theranostic Nanomedicine, Research Department, Faculty of Medicine Siriraj Hospital","place":["Bangkok, Thailand"]},{"name":"Mahidol University","place":["Bangkok, Thailand"]},{"name":"Department of Biochemistry, Faculty of Medicine Siriraj Hospital","place":["Bangkok, Thailand"]},{"name":"Mahidol University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Bioengineering","place":["Arlington, United States"]},{"name":"University of Texas at Arlington","place":["Arlington, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2767-510X","authenticated-orcid":true,"given":"Primana","family":"Punnakitikashem","sequence":"additional","affiliation":[{"name":"Siriraj Center of Research Excellence in Theranostic Nanomedicine, Research Department, Faculty of Medicine Siriraj Hospital","place":["Bangkok, Thailand"]},{"name":"Mahidol University","place":["Bangkok, Thailand"]},{"name":"Department of Biochemistry, Faculty of Medicine Siriraj Hospital","place":["Bangkok, Thailand"]},{"name":"Mahidol University","place":["Bangkok, Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"ref1\/cit1","unstructured":"AANS. Glioblastoma Multiforme. 2024. https:\/\/www.aans.org\/patients\/conditions-treatments\/glioblastoma-multiforme\/ (accessed November, 2025)."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2015.473"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17010146"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2023.03.013"},{"key":"ref5\/cit5","first-page":"187","volume-title":"Drug Delivery","author":"Ita K.","year":"2025"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2013.11.017"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15141"},{"key":"ref8\/cit8a","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102029"},{"key":"ref8\/cit8b","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-024-08213-7"},{"key":"ref9\/cit9a","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-35762-3.00057-3"},{"key":"ref9\/cit9b","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1339597"},{"key":"ref10\/cit10a","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmt.2023.09.001"},{"key":"ref10\/cit10b","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01668-1"},{"key":"ref11\/cit11a","doi-asserted-by":"publisher","DOI":"10.3390\/ph17020169"},{"key":"ref11\/cit11b","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.02.044"},{"key":"ref12\/cit12a","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-024-02114-5"},{"key":"ref12\/cit12b","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb4429"},{"key":"ref13\/cit13a","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75125-2"},{"key":"ref13\/cit13b","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08993"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103839"},{"key":"ref15\/cit15a","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c05976"},{"key":"ref15\/cit15b","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.10.015"},{"key":"ref15\/cit15c","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c14625"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14081560"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jciso.2023.100087"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-019-0529-4"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1063\/5.0247029"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adw0730"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsadv.2025.100891"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111654"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S450853"},{"key":"ref24\/cit24a","doi-asserted-by":"publisher","DOI":"10.1021\/jm2014919"},{"key":"ref24\/cit24b","doi-asserted-by":"publisher","DOI":"10.3390\/biology9070161"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3390\/nano10050906"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202000092"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-021-03584-1"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1039\/D4PM00053F"},{"key":"ref29\/cit29a","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12481"},{"key":"ref29\/cit29b","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.102214"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2018.1468768"},{"issue":"9","key":"ref31\/cit31","first-page":"3669","volume":"61","author":"Bethune C. R.","year":"2001","journal-title":"Cancer Res."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.34133\/research.0148"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150115144003"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.01.022"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(99)00186-8"},{"key":"ref36\/cit36a","doi-asserted-by":"publisher","DOI":"10.1021\/jp1043943"},{"key":"ref36\/cit36b","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.07.001"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3390\/ph17050612"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1039\/D4NA00783B"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.04.033"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/mp200439z"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2023.103505"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.369"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.2174\/1874126600802010026"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.08.021"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910150416"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.onano.2024.100231"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1520078"},{"key":"ref48\/cit48a","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-019-0134-9"},{"key":"ref48\/cit48b","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.110804"},{"key":"ref48\/cit48c","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.236"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065283"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c01330","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c01330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:10:26Z","timestamp":1782825026000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.6c01330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":62,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2026,6,30]]}},"alternative-id":["10.1021\/acsomega.6c01330"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c01330","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]}}}