{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:05:23Z","timestamp":1792530323558,"version":"4.5.0"},"reference-count":58,"publisher":"American Chemical Society (ACS)","issue":"27","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2021\/08152-0"],"award-info":[{"award-number":["2021\/08152-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2021\/14992-1"],"award-info":[{"award-number":["2021\/14992-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2023\/05407-3"],"award-info":[{"award-number":["2023\/05407-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2025\/00783-2"],"award-info":[{"award-number":["2025\/00783-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["24\/11121-8"],"award-info":[{"award-number":["24\/11121-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["25\/22367-0"],"award-info":[{"award-number":["25\/22367-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2026,7,14]]},"DOI":"10.1021\/acsomega.6c01781","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:29:38Z","timestamp":1782732578000},"page":"40005-40017","source":"Crossref","is-referenced-by-count":1,"title":["A Simple, Organic Solvent-Free, and Scalable Process for Producing Calcium Alginate Nanoparticle Powder by High-Pressure Homogenization and Spray Drying"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1399-4054","authenticated-orcid":true,"given":"Paulo Augusto","family":"Marques Chagas","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto","place":["Ribeir\u00e3o Preto, Brazil"]},{"name":"University of S\u00e3o Paulo (FCFRP USP)","place":["Ribeir\u00e3o Preto, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7551-0510","authenticated-orcid":true,"given":"Jo\u00e3o Ot\u00e1vio Donizette","family":"Malafatti","sequence":"additional","affiliation":[{"name":"National Laboratory for Nanotechnology for Agriculture (LNNA), Embrapa Instrumenta\u00e7\u00e3o, Rua XV de Novembro 1452, Centro, S\u00e3o Carlos, SP 13561-206, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia Rodrigues","family":"Boueri de Souza","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto","place":["Ribeir\u00e3o Preto, Brazil"]},{"name":"University of S\u00e3o Paulo (FCFRP USP)","place":["Ribeir\u00e3o Preto, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9338-7846","authenticated-orcid":true,"given":"Maria Sirlene","family":"Morais","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto","place":["Ribeir\u00e3o Preto, Brazil"]},{"name":"University of S\u00e3o Paulo (FCFRP USP)","place":["Ribeir\u00e3o Preto, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela F\u00e1vero","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto","place":["Ribeir\u00e3o Preto, Brazil"]},{"name":"University of S\u00e3o Paulo (FCFRP USP)","place":["Ribeir\u00e3o Preto, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0896-7385","authenticated-orcid":true,"given":"Guilherme Alves","family":"Pinto","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto","place":["Ribeir\u00e3o Preto, Brazil"]},{"name":"University of S\u00e3o Paulo (FCFRP USP)","place":["Ribeir\u00e3o Preto, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7586-1014","authenticated-orcid":true,"given":"Luiz Henrique","family":"Capparelli Mattoso","sequence":"additional","affiliation":[{"name":"National Laboratory for Nanotechnology for Agriculture (LNNA), Embrapa Instrumenta\u00e7\u00e3o, Rua XV de Novembro 1452, Centro, S\u00e3o Carlos, SP 13561-206, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4356-2508","authenticated-orcid":true,"given":"Wanderley Pereira de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto","place":["Ribeir\u00e3o Preto, Brazil"]},{"name":"University of S\u00e3o Paulo (FCFRP USP)","place":["Ribeir\u00e3o Preto, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.139151"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2023.104217"},{"key":"ref3\/cit3","volume-title":"Alginates in Drug Delivery 129\u2013152","author":"Hasnain M. S.","year":"2020"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.02.086"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2022.102744"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2016.01.033"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2016.04.025"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012108"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.05.037"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2022.110960"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2024.104412"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2022.111222"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.scient.2012.10.005"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/cjce.70331"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2020.104820"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121280"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2011.06.003"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125851"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1081\/MC-120020160"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125570"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2025.116849"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2022.12.096"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.04.017"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2005.07.033"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2015.05.010"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2025.111901"},{"key":"ref27\/cit27","first-page":"263","volume-title":"Emerging Technologies for Nanoparticle Manufacturing","author":"Vinchhi P.","year":"2021"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124799"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2021.112607"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2023.109533"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2020.105886"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2017.02.011"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2011.03.001"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.01.139"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c08627"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.06.017"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.04.081"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/733\/1\/012039"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/MSF.964.240"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118399"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.04.138"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/star.202000282"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/polym10090990"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.1c01254"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3390\/polym15143012"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1039\/D0TA09315G"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/app.20589"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.08.103"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.144639"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.renene.2016.04.012"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9614(86)90130-8"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3390\/biom10050693"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2022.113766"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjp.2016.10.006"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA06103J"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-025-03611-6"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2011.08.014"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3390\/ma11091522"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c01781","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c01781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:03:49Z","timestamp":1784041429000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.6c01781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":58,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2026,7,14]]}},"alternative-id":["10.1021\/acsomega.6c01781"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c01781","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]}}}