{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:13:08Z","timestamp":1788221588318,"version":"build-2803163510"},"reference-count":68,"publisher":"American Chemical Society (ACS)","issue":"33","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/na","name":"Can Tho University","doi-asserted-by":"publisher","award":["T2025-08"],"award-info":[{"award-number":["T2025-08"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Amphotericin B (AmB) is a poorly water-soluble drug with low oral bioavailability and high nephrotoxicity. Thus, this study developed oral AmB-loaded pH-sensitive Eudragit L100-functionalized silk fibroin nanoparticles (SF\/EL-AmB) to enhance its oral bioavailability and reduce its renal toxicity. The particles were formulated using two different methods of desolvation and adsorption, followed by thorough characterizations regarding particle size, polydispersity index, zeta potential, chemical interactions, AmB entrapment efficiency, specific surface area, drug release in simulated oral conditions, and in vitro antifungal activity. The optimal formula (SF:EL ratio of 1:3 and initial AmB amount of 0.5 mg) yielded particles with average size of 577.9 nm, zeta potential of \u221247.9 mV, drug loading efficiency of 77.99 \u00b1 2.35%, specific surface area of 38.969 m2\/g with mostly mesopores, and moderate in vitro antifungal activity on Candida albicans with IC50 of 4.09 \u00b1 0.21 \u03bcg\/mL and MIC of 32.0 \u03bcg\/mL. Analytical techniques (XRD, DSC, and FTIR) and in silico modeling confirmed that AmB was entrapped within the SF\/EL nanoparticles in an amorphous molecular dispersion state via hydrogen bonding and ionic interactions between AmB and charged residues of SF, notably Lys82, Glu98, and Lys62. Interestingly, the SF\/EL nanoparticles could protect AmB through the stomach acidic condition and control its release rate in the small intestine based on the formulation methods (desolvation or adsorption). Lastly, the SF\/EL-AmB nanoparticles could reduce AmB aggregation forms, which theoretically links to a decrease in AmB nephrotoxicity. In conclusion, the SF\/EL-AmB nanoparticles could be further investigated to become a novel product for oral AmB delivery.<\/jats:p>","DOI":"10.1021\/acsomega.6c01865","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:02:02Z","timestamp":1786424522000},"page":"49240-49254","source":"Crossref","is-referenced-by-count":0,"title":["Development of\nOral pH-Sensitive Eudragit L100-Functionalized\n                    <i>Bombyx mori<\/i>\n                    Silk Fibroin Nanoparticles Containing\nAmphotericin B: Formulations, Characterizations,\n                    <i>In Silico<\/i>\n                    Molecular Investigations, and Antifungal Activity Evaluation"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5487-414X","authenticated-orcid":true,"given":"Bui Thi Phuong","family":"Thuy","sequence":"first","affiliation":[{"name":"Van Lang University , , ,","place":["Ho Chi Minh City, Vietnam, 70000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong T. M.","family":"Ha","sequence":"additional","affiliation":[{"name":"Tay Do University , , 68 Tran Chien Street , Thanh My Area Cai Rang Ward, ,","place":["Can Tho, Vietnam, 94000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Yen","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Can Tho University , , ,","place":["Can Tho, Vietnam, 94000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"Trong Tuan","sequence":"additional","affiliation":[{"name":"Can Tho University , , ,","place":["Can Tho, Vietnam, 94000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huynh Vu Thanh","family":"Luong","sequence":"additional","affiliation":[{"name":"Can Tho University , , ,","place":["Can Tho, Vietnam, 94000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9304-5544","authenticated-orcid":true,"given":"Quyen Thi Bich","family":"Tran","sequence":"additional","affiliation":[{"name":"Can Tho University , , ,","place":["Can Tho, Vietnam, 94000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trieu Phu","family":"Hau","sequence":"additional","affiliation":[{"name":"Can Tho University , , ,","place":["Can Tho, Vietnam, 94000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-3367","authenticated-orcid":true,"given":"Duy Toan","family":"Pham","sequence":"additional","affiliation":[{"name":"Can Tho University , , ,","place":["Can Tho, Vietnam, 94000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"2026083119151756800_cit1","doi-asserted-by":"publisher","first-page":"5268","DOI":"10.1007\/s10853-020-04350-x","article-title":"Development\nof amphotericin B-loaded fibroin nanoparticles: a novel approach for\ntopical ocular application","volume":"55","author":"Chomchalao","year":"2020","journal-title":"J. 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Infect."},{"key":"2026083119151756800_cit5","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00336","article-title":"Antifungal Therapy\nfor Systemic Mycosis and the Nanobiotechnology\nEra: Improving Efficacy, Biodistribution and Toxicity","volume":"8","author":"Souza","year":"2017","journal-title":"Front. Microbiol."},{"key":"2026083119151756800_cit6","doi-asserted-by":"publisher","DOI":"10.3390\/polym16010148","article-title":"Mucoadhesive\nHybrid System of Silk Fibroin Nanoparticles and Thermosensitive In\nSitu Hydrogel for Amphotericin B Delivery: A Potential Option for\nFungal Keratitis Treatment","volume":"16","author":"Chomchalao","year":"2024","journal-title":"Polymers"},{"key":"2026083119151756800_cit7","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1021\/mp9001602","article-title":"Synthesis\nof a Highly Water-Soluble\nDerivative of Amphotericin B with Attenuated Proinflammatory Activity","volume":"6","author":"Adediran","year":"2009","journal-title":"Mol. 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