{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:24:47Z","timestamp":1786465487890,"version":"build-2736575974"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell?Istruzione, dell?Universit? e della Ricerca","doi-asserted-by":"publisher","award":["PRIN 2022 2022YFYTY2"],"award-info":[{"award-number":["PRIN 2022 2022YFYTY2"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>PET radiotracer [18F]MC225 is in two different clinical trials for imaging P-glycoprotein (P-gp) at the BBB level. This radiotracer permits to evaluate both the inset of neurodegenerative pathologies such as MCI, AD, and PD and the drug resistance of antidepressant drugs. Although these studies are ongoing, it is known that in MCI, AD, and PD the activity and expression of P-gp at the BBB level is lower than in healthy subjects, whereas the activity of the same pump is high in human subjects with resistance to antidepressant therapy. This level of P-gp is measured by PET with [18F]MC225 that displayed high brain uptake in neurodegenerative diseases and low brain uptake in subjects with resistance versus several antidepressant drugs. Starting from the mentioned PET radiotracer, a series of conformationally free derivatives have been synthesized testing the role of isosteric substitution in terms of P-gp interactions. Aryl-(oxy)-derivative 2c showed in vitro higher P-gp activity than MC225 (EC50 = 1.8 \u03bcM vs EC50 = 6.35 \u03bcM). This result has been corroborated with molecular docking, RMSD, and Rog timeline plot. The results disclosed a class of compounds, among them, 2c could be easily [11C]\/[18F] radiolabeled for in vivo studies. Considering the lower lipophilicity of 2c than MC225, this ligand could be radiolabeled for imaging P-glycoprotein function and expression that is involved in several heart failures, where a low log P is an important and prelaminar parameter to drug targeting.<\/jats:p>","DOI":"10.1021\/acsomega.6c02050","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:18:43Z","timestamp":1785849523000},"page":"45949-45963","source":"Crossref","is-referenced-by-count":0,"title":["From 18F-MC225 to Conformationally\nFree Derivatives"],"prefix":"10.1021","volume":"11","author":[{"given":"Anna Teresa","family":"Lisi","sequence":"first","affiliation":[{"name":"University of Bari Aldo Moro , , ,","place":["Bari, Italy, 70125"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Mastropasqua","sequence":"additional","affiliation":[{"name":"University of Bari Aldo Moro , , ,","place":["Bari, Italy, 70125"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9292-884X","authenticated-orcid":true,"given":"Carmen","family":"Abate","sequence":"additional","affiliation":[{"name":"University of Bari Aldo Moro , , ,","place":["Bari, Italy, 70125"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0713-3151","authenticated-orcid":true,"given":"Marialessandra","family":"Contino","sequence":"additional","affiliation":[{"name":"University of Bari Aldo Moro , , ,","place":["Bari, Italy, 70125"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4195-5228","authenticated-orcid":true,"given":"Maria Grazia","family":"Perrone","sequence":"additional","affiliation":[{"name":"University of Bari Aldo Moro , , ,","place":["Bari, Italy, 70125"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5575-3240","authenticated-orcid":true,"given":"Giovanni","family":"Graziano","sequence":"additional","affiliation":[{"name":"University of Bari Aldo Moro , , ,","place":["Bari, Italy, 70125"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7725-6667","authenticated-orcid":true,"given":"Antonio","family":"Carrieri","sequence":"additional","affiliation":[{"name":"University of Bari Aldo Moro , , ,","place":["Bari, Italy, 70125"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5639-7746","authenticated-orcid":true,"given":"Nicola Antonio","family":"Colabufo","sequence":"additional","affiliation":[{"name":"University of Bari Aldo Moro , , ,","place":["Bari, Italy, 70125"]},{"name":"Biofordrug. Spin-off of Bari University , via Dante 95\/99 , Triggiano (Bari), ,","place":["Bari, Italy, 70019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6769-7610","authenticated-orcid":true,"given":"Cristina","family":"Filosa","sequence":"additional","affiliation":[{"name":"Biofordrug. Spin-off of Bari University , via Dante 95\/99 , Triggiano (Bari), ,","place":["Bari, Italy, 70019"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lucia","family":"Calcagni","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli, IRCSS , , Largo Francesco Vito 1 , ,","place":["Rome, Italy, 00168"]},{"name":"Universita\u0300 Cattolica del Sacro Cuore , , ,","place":["Rome, Italy, 00168"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Giordano","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli, IRCSS , , Largo Francesco Vito 1 , ,","place":["Rome, Italy, 00168"]},{"name":"Universita\u0300 Cattolica del Sacro Cuore , , ,","place":["Rome, Italy, 00168"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Di Giuda","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli, IRCSS , , Largo Francesco Vito 1 , ,","place":["Rome, Italy, 00168"]},{"name":"Universita\u0300 Cattolica del Sacro Cuore , , ,","place":["Rome, Italy, 00168"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"2026081110182849500_cit1","doi-asserted-by":"publisher","first-page":"1597902","DOI":"10.3389\/fnume.2025.1597902","article-title":"Evaluating\nimage-derived input functions for cerebral [18F]MC225 PET\nstudies","volume":"5","author":"Salvi de Souza","year":"2025","journal-title":"Front. Nucl. Med."},{"key":"2026081110182849500_cit2","doi-asserted-by":"publisher","first-page":"4604","DOI":"10.1007\/s00259-025-07320-0","article-title":"Measurement\nof cyclosporin induced changes in P-glycoprotein function at the human\nblood-brain barrier using [18F]MC225 and PET","volume":"52","author":"Mossel","year":"2025","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"2026081110182849500_cit3","doi-asserted-by":"publisher","DOI":"10.1111\/cts.70196","article-title":"Exploratory Study of Sex Differences\nin P-Glycoprotein Function at the Blood-Brain Barrier","volume":"18","author":"Salvi de Souza","year":"2025","journal-title":"Clin. Transl. Sci."},{"key":"2026081110182849500_cit4","doi-asserted-by":"publisher","first-page":"3696","DOI":"10.3390\/molecules30183696","article-title":"Designing a Small\nMolecule for PET Radiotracing: [18F]MC225 in Human Trials\nfor Early Diagnosis in CNS Pathologies","volume":"30","author":"Mastropasqua","year":"2025","journal-title":"Molecules"},{"key":"2026081110182849500_cit5","doi-asserted-by":"publisher","first-page":"5774","DOI":"10.2174\/1381612822666160810114008","article-title":"Design\nand Synthesis of New Selective P-gp Substrates and Inhibitors","volume":"22","author":"Cantore","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"2026081110182849500_cit6","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.2174\/156802610792928022","article-title":"Substrates, inhibitors\nand activators of P-glycoprotein: candidates for radiolabeling and\nimaging perspectives","volume":"10","author":"Colabufo","year":"2010","journal-title":"Curr. Top. Med. Chem."},{"key":"2026081110182849500_cit7","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/cmdc.201500420","article-title":"(11)C- and\n(18)F-Labeled Radioligands\nfor P-Glycoprotein Imaging by Positron Emission Tomography","volume":"11","author":"Cantore","year":"2016","journal-title":"ChemMedChem"},{"key":"2026081110182849500_cit8","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1002\/cpt.73","article-title":"Radiopharmaceuticals for assessing ABC transporters\nat the blood-brain barrier","volume":"97","author":"Raaphorst","year":"2015","journal-title":"Clin. Pharmacol.\nTher."},{"key":"2026081110182849500_cit9","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/7651_2020_308","article-title":"Blood-Brain\nBarrier (BBB) Permeability\nand Transport Measurement in Vitro and in Vivo","volume":"2367","author":"Fu","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"2026081110182849500_cit11","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s40262-015-0310-2","article-title":"Reliability of In Vitro and In Vivo\nMethods for Predicting the Effect of P-Glycoprotein on the Delivery\nof Antidepressants to the Brain","volume":"55","author":"Zheng","year":"2016","journal-title":"Clin. Pharmacokinet."},{"key":"2026081110182849500_cit12","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/tpj.2014.72","article-title":"ABCB1 (MDR1) predicts remission on P-gp substrates\nin chronic depression","volume":"15","author":"Ray","year":"2015","journal-title":"Pharmacogenomics J."},{"key":"2026081110182849500_cit13","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s00213-006-0437-9","article-title":"Evaluation\nof antipsychotic drugs as inhibitors of multidrug resistance transporter\nP-glycoprotein","volume":"187","author":"Wang","year":"2006","journal-title":"Psychopharmacology"},{"key":"2026081110182849500_cit14","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1017\/s1461145709009894","article-title":"Locally increased\nP-glycoprotein function in major depression: a PET study with [11C]verapamil as a probe for P-glycoprotein function in the\nblood-brain barrier","volume":"12","author":"de Klerk","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"2026081110182849500_cit15","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1007\/s12149-021-01666-9","article-title":"First clinical assessment\nof [18F]MC225, a novel fluorine-18 labelled PET tracer\nfor measuring functional P-glycoprotein at the blood-brain barrier","volume":"35","author":"Toyohara","year":"2021","journal-title":"Ann. Nucl. Med."},{"key":"2026081110182849500_cit16","doi-asserted-by":"publisher","first-page":"4105","DOI":"10.1007\/s00259-021-05419-8","article-title":"Evaluation of P-glycoprotein function\nat the blood-brain barrier using [18F]MC225-PET","volume":"48","author":"Mossel","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"2026081110182849500_cit17","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1177\/002215540205001008","article-title":"Expression and localization\nof P-glycoprotein in human heart: effects of cardiomyopathy","volume":"50","author":"Meissner","year":"2002","journal-title":"J. Histochem. Cytochem."},{"issue":"6","key":"2026081110182849500_cit18","doi-asserted-by":"publisher","first-page":"4291","DOI":"10.1021\/acs.joc.1c03135","article-title":"Transition\nMetal Free Stannylation of Alkyl Halides: The Rapid Synthesis\nof Alkyltrimethylstannanes","volume":"87","author":"Li","year":"2022","journal-title":"J. Org. Chem."},{"issue":"3","key":"2026081110182849500_cit19","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1016\/j.bmc.2009.12.035","article-title":"Synthesis biological\nevaluation, and molecular modeling of berberine\nderivatives as potent acetylcholinesterase inhibitors","volume":"18","author":"Huang","year":"2010","journal-title":"Bioorg. Med. Chem."},{"issue":"2","key":"2026081110182849500_cit20","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.dyepig.2009.08.001","article-title":"The photocatalytic\nactivity of novel, substituted porphyrin\/TiO2-based composites","volume":"84","author":"Wang","year":"2010","journal-title":"Dyes Pigm."},{"key":"2026081110182849500_cit21","doi-asserted-by":"publisher","first-page":"6175315","DOI":"10.1155\/2017\/6175315","article-title":"An Efficient\nK2CO3-Promoted Synthesis of 1-Bromo-2-aryloxyethane\nDerivatives\nand Evaluation of Larval Mortality against","author":"Pa\u0301jaro","year":"2017","journal-title":"Aedes aegypti. J. Chem."},{"issue":"23","key":"2026081110182849500_cit22","doi-asserted-by":"publisher","first-page":"5025","DOI":"10.1016\/j.bmc.2003.08.026","article-title":"Structure-based drug\ndesign: synthesis,\ncrystal structure, biological evaluation and docking studies of mono-\nand bis-benzo[b]oxepines as non-steroidal estrogens","volume":"11","author":"Sarkhel","year":"2003","journal-title":"Bioorg. Med. Chem."},{"issue":"18","key":"2026081110182849500_cit23","doi-asserted-by":"publisher","first-page":"8729","DOI":"10.1016\/j.bmc.2008.07.071","article-title":"Piperidine\nvariations\nin search for non-imidazole histamine H3 receptor ligands","volume":"16","author":"\u0141az\u0307ewska","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"2026081110182849500_cit24","doi-asserted-by":"publisher","first-page":"10946","DOI":"10.1021\/acs.jmedchem.0c00814","article-title":"Discovery of Novel pERK1\/2- or \u03b2-Arrestin-Preferring\n5-HT1A Receptor-Biased Agonists: Diversified Therapeutic-like\nversus Side Effect Profile","volume":"63","author":"Sniecikowska","year":"2020","journal-title":"J. Med. Chem."},{"issue":"11","key":"2026081110182849500_cit25","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1002\/anie.200503733","article-title":"Synthesis of the\nC1\u2013C26 Northern Portion of\nAzaspiracid-1: Kinetic versus Thermodynamic Control of the Formation\nof the Bis-spiroketal","volume":"45","author":"Zhou","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"issue":"11","key":"2026081110182849500_cit26","doi-asserted-by":"publisher","first-page":"5314","DOI":"10.1021\/jo400371x","article-title":"Asymmetric Synthesis of Nonracemic\nPrimary Amines via Spiroborate-Catalyzed Reduction of Pure (E)- and (Z)-O-Benzyloximes:\nApplications toward the Synthesis of Calcimimetic Agents","volume":"78","author":"Ou","year":"2013","journal-title":"J. Org. Chem."},{"issue":"18","key":"2026081110182849500_cit27","doi-asserted-by":"publisher","first-page":"5830","DOI":"10.1016\/j.bmc.2013.07.011","article-title":"Synthesis\nand biological evaluation of berberine-thiophenyl hybrids as multi-functional\nagents: Inhibition of acetylcholinesterase, butyrylcholinesterase,\nand A\u03b2 aggregation and antioxidant activity","volume":"21","author":"Su","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"2026081110182849500_cit28","doi-asserted-by":"publisher","first-page":"115163","DOI":"10.1016\/j.ejmech.2023.115163","article-title":"Novel S1R agonists counteracting\nNMDA excitotoxicity\nand oxidative stress: A step forward in the discovery of neuroprotective\nagents","volume":"249","author":"Linciano","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"31","key":"2026081110182849500_cit29","doi-asserted-by":"publisher","first-page":"8417","DOI":"10.1021\/acs.orglett.5c02110","article-title":"Camphor-Based NHC Ligands with a\nSulfur Ligator Atom in Rhodium Catalysis: Catalytic Advances in the\nAsymmetric Ring Opening of N-Protected Azabenzonorbornenes","volume":"27","author":"Kamzol","year":"2025","journal-title":"Org. Lett."},{"key":"2026081110182849500_cit30","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.3762\/bjoc.14.251","article-title":"Photocatalyic Appel\nreaction enabled by copper-based complexes in continuous flow","volume":"14","author":"Minozzi","year":"2018","journal-title":"Beilstein J. Org. Chem."},{"key":"2026081110182849500_cit31","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1016\/s0040-4039(00)00330-0","article-title":"Efficient\nsynthesis of \u03b2-amino bromides","volume":"41","author":"Nagle","year":"2000","journal-title":"Tetrahedron\nLett."},{"key":"2026081110182849500_cit32","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1039\/D1GC03440E","article-title":"Divergent\nelectrolysis for the controllable coupling\nof thiols with 1,2-dichloroethane: a mild approach to sulfide and\nsulfoxide","volume":"24","author":"Ling","year":"2022","journal-title":"Green Chem."},{"key":"2026081110182849500_cit33","doi-asserted-by":"publisher","first-page":"114444","DOI":"10.1016\/j.ejmech.2022.114444","article-title":"Structure-based discovery and development\nof novel O-GlcNAcase inhibitors for the treatment of Alzheimer\u2019s\ndisease","volume":"238","author":"Li","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"2026081110182849500_cit34","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1124\/jpet.102.039255","article-title":"Passive permeability\nand P-glycoprotein-mediated efflux differentiate central nervous system\n(CNS) and non-CNS marketed drugs","volume":"303","author":"Doan","year":"2002","journal-title":"J. Pharmacol.\nExp. Ther."},{"key":"2026081110182849500_cit35","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.3390\/ijms21093333","article-title":"MRP1-Collateral Sensitizers\nas a Novel Therapeutic Approach in Resistant Cancer Therapy: An in\nvitro and in vivo Study in Lung Resistant Tumor","volume":"21","author":"Riganti","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2026081110182849500_cit36","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1002\/cmdc.201700239","article-title":"Structure-Activity Relationship Studies\non 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives\nas Multidrug Resistance Reversers","volume":"12","author":"Teodori","year":"2017","journal-title":"ChemMedChem"},{"key":"2026081110182849500_cit37","unstructured":"Schro\u0308dinger Release 2025\u20134 Maestro, Schro\u0308dinger, LLC, New York, NY, 2025."},{"key":"2026081110182849500_cit38","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open Babel: An open chemical toolbox","volume":"3","author":"O\u2019Boyle","year":"2011","journal-title":"J. Cheminf."},{"key":"2026081110182849500_cit39","doi-asserted-by":"publisher","first-page":"5179","DOI":"10.1021\/ja00124a002","article-title":"A second generation force field for\nthe simulation\nof proteins, nucleic acids, and organic molecules","volume":"117","author":"Cornell","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"2026081110182849500_cit40","unstructured":"QUACPAC 2.1.0.4; OpenEye Scientific\nSoftware, Santa Fe, NM."},{"key":"2026081110182849500_cit41","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14&lt;1639::AID-JCC10&gt;3.0.CO;2-B","article-title":"Automated\ndocking using a Lamarckian\ngenetic algorithm and empirical binding free energy function","volume":"19","author":"Morris","year":"1998","journal-title":"J. Comput. Chem."},{"key":"2026081110182849500_cit42","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s10822-019-00240-w","article-title":"Comparison of affinity\nranking using AutoDock-GPU and MM-GBSA scores for BACE-1 inhibitors\nin the D3R Grand Challenge 4","volume":"33","author":"El Khoury","year":"2019","journal-title":"J. Comput. Aided\nMol. Des."},{"key":"2026081110182849500_cit43","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1021\/jm2005145","article-title":"A force field with\ndiscrete displaceable waters and\ndesolvation entropy for hydrated ligand docking","volume":"55","author":"Forli","year":"2012","journal-title":"J. Med. Chem."},{"key":"2026081110182849500_cit44","doi-asserted-by":"crossref","unstructured":"Bowers, K. J.; Chow, E.; Xu, H.; Dror, R. O.; Eastwood, M. P.; Gregersen, B. A.; Klepeis, J. L.; Kolossvary, I.; Moraes, M. A.; Sacerdoti, F. D.; Salmon, J. K.; Shan, Y.; Shaw, D. E.\n          Scalable algorithms\nfor molecular\ndynamics simulations on commodity clusters. In  Proceedings of the ACM\/IEEE Conference on Supercomputing (SC06); Tampa: Florida, 2006.","DOI":"10.1145\/1188455.1188544"},{"key":"2026081110182849500_cit45","unstructured":"Schro\u0308dinger\nRelease 2025\u20134: Desmond Molecular\nDynamics System, D. E. Shaw Research, New York, NY, 2024. Maestro-Desmond\nInteroperability Tools; Schro\u0308dinger, New York, NY, 2025."},{"issue":"42","key":"2026081110182849500_cit46","doi-asserted-by":"publisher","first-page":"26245","DOI":"10.1073\/pnas.2010264117","article-title":"Cryo-EM\nstructures reveal distinct\nmechanisms of inhibition of the human multidrug transporter ABCB1","volume":"117","author":"Nosol","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"36","key":"2026081110182849500_cit47","doi-asserted-by":"publisher","first-page":"24074","DOI":"10.1074\/jbc.M109.023267","article-title":"Identification of\nresidues in the\ndrug translocation pathway of the human multidrug resistance P-glycoprotein\nby arginine mutagenesis","volume":"284","author":"Loo","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2026081110182849500_cit48","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/bs.acr.2014.10.003","article-title":"Molecular\nbasis of the polyspecificity\nof P-glycoprotein (ABCB1): recent biochemical and structural studies","volume":"125","author":"Chufan","year":"2015","journal-title":"Adv. Cancer Res."},{"issue":"5","key":"2026081110182849500_cit49","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1039\/C8MD00075A","article-title":"New tetrahydroisoquinoline-based\nP-glycoprotein modulators: decoration of the biphenyl core gives selective\nligands","volume":"9","author":"Contino","year":"2018","journal-title":"MedChemComm"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c02050","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/31\/45949\/66333129\/acsomega.6c02050.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/31\/45949\/66333129\/acsomega.6c02050.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:01:23Z","timestamp":1786460483000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/11\/31\/45949\/5236924\/From-18F-MC225-to-Conformationally-Free"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,29]]},"references-count":48,"journal-issue":{"issue":"31","published-online":{"date-parts":[[2026,7,29]]},"published-print":{"date-parts":[[2026,8,11]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c02050","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,29]]}}}