{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:47:51Z","timestamp":1791924471265,"version":"4.3.4"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"40","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-00573060"],"award-info":[{"award-number":["RS-2025-00573060"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic inflammation following biomaterial implantation often leads to fibrous encapsulation and compromised osseointegration, particularly in clinically inflamed environments. We developed a surface-functionalized poly(\u03b5-caprolactone) (PCL) platform to modulate the early inflammatory microenvironment via surface-mediated drug release. PCL films were aminated by plasma polymerization, enabling the electrostatic immobilization of naproxen. Surface characterization by zeta potential analysis, X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM) confirmed successful amine functionalization and subsequent naproxen loading. The functionalized films exhibited a pronounced early burst release of naproxen within the initial hours after immersion, addressing the early phase of post-surgical inflammation. In vitro studies using MC3T3-E1 pre-osteoblasts under lipopolysaccharide (LPS)-induced inflammatory conditions showed that naproxen released from the surface significantly reduced pro-inflammatory cytokine secretion, including IL-6 and IL-1\u03b2. The cytokine-suppressive effect of the naproxen-functionalized surface was further supported by mechanistic experiments showing that soluble naproxen attenuated LPS-induced NF-\u03baB p65 phosphorylation and nuclear translocation. These results suggest that the anti-inflammatory response mediated by surface-released naproxen is, at least in part, attributable to the intrinsic NF-\u03baB-modulating activity of naproxen. Modulation of the inflammatory microenvironment restored osteogenic differentiation, with increased expression of RUNX2, ALP, and OPN, and enhanced matrix mineralization, as confirmed by Alizarin Red S staining. These findings demonstrate that surface-mediated delivery of naproxen enables temporally controlled osteoimmunomodulation and supports osteogenic function under inflammatory stress, underscoring the potential of this surface-engineering strategy for bone-regenerative applications.<\/jats:p>","DOI":"10.1021\/acsomega.6c02070","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:01:58Z","timestamp":1790913718000},"page":"60722-60733","source":"Crossref","is-referenced-by-count":0,"title":["Surface-Mediated\nImmunomodulation by Electrostatic\nImmobilization of Naproxen on Plasma-Aminated Poly(\u03b5-caprolactone)\nFilms Rescues Osteogenic Differentiation via Attenuation of NF-\u03baB\nSignaling"],"prefix":"10.1021","volume":"11","author":[{"given":"Chang-Young","family":"Kim","sequence":"first","affiliation":[{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2992-3621","authenticated-orcid":true,"given":"Namuun","family":"Khentii","sequence":"additional","affiliation":[{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0859-784X","authenticated-orcid":true,"given":"Ji-Hun","family":"Seok","sequence":"additional","affiliation":[{"name":"Chosun University , , ,","place":["Gwangju, Republic of Korea, 61452"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9310-8139","authenticated-orcid":true,"given":"Tien Ngoc","family":"Thuy Nguyen","sequence":"additional","affiliation":[{"name":"Chosun University , , ,","place":["Gwangju, Republic of Korea, 61452"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-8534","authenticated-orcid":true,"given":"Min-Suk","family":"Kook","sequence":"additional","affiliation":[{"name":"Chonnam National University , , ,","place":["Gwangju, Republic of Korea, 61186"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"issue":"1","key":"2026101315092809600_cit1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.it.2013.09.001","article-title":"Immunomicrobial\npathogenesis of periodontitis: keystones, pathobionts, and host response","volume":"35","author":"Hajishengallis","year":"2014","journal-title":"Trends Immunol."},{"key":"2026101315092809600_cit2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.bone.2016.02.020","article-title":"Inflammation,\nFracture and Bone Repair","volume":"86","author":"Loi","year":"2016","journal-title":"Bone"},{"issue":"2","key":"2026101315092809600_cit3","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"Anderson","year":"2008","journal-title":"Semin. 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