{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:09:40Z","timestamp":1791256180040,"version":"4.1.0"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"29","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["52\/13\/2022-BIO\/BMS"],"award-info":[{"award-number":["52\/13\/2022-BIO\/BMS"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006464","name":"Birla Institute of Technology and Science, Pilani","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006464","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metabolic-dysfunction-associated steatotic liver disease (MASLD) begins with simple steatosis and progresses to metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, cirrhosis, and liver cancer, primarily driven by increased adiposity, oxidative stress, pro-inflammatory cytokines (such as IL-17), and an imbalance between immune mediators. The multifactorial nature of the disease necessitates combination therapies targeting both inflammatory and lipogenic pathways. Here, the edible pigment Bixin, together with the anti-inflammatory drug Montelukast, was evaluated in an in vitro fluid-dynamic cell culture system of steatotic HepG2 cells induced with the IL-17 cytokine. This model mimicked the progression from hepatic steatosis to cytokine-driven inflammatory stress, marked by elevated levels of pro-inflammatory cytokines, IL-6, and TNF-\u03b1. Bixin\u2013Montelukast combination decreased intracellular neutral-lipid accumulation by 34.88%, diminished oxidative stress (29.67% and 41.55% decrease in ROS and malondialdehyde levels, respectively), and decreased liver injury (18.91% decrease in ALT activity). The combination significantly (p &amp;lt; 0.05) downregulated key inflammatory mediators (IL-6, TNF-\u03b1) and gene\/protein expressions of the lipogenic marker SCD1. Bixin, when combined with Montelukast, ameliorated hepatic lipid accumulation, oxidative stress, lipotoxicity, and inflammation. Such nutraceutical-drug treatment may be a promising strategy to limit disease progression from simple steatosis to cytokine-driven inflammatory sequel of MASLD.<\/jats:p>","DOI":"10.1021\/acsomega.6c02338","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:43:12Z","timestamp":1784230992000},"page":"43555-43565","source":"Crossref","is-referenced-by-count":1,"title":["Bixin and Montelukast\nCombination Mitigates the Progression\nof MASLD to Cytokine-Driven Inflammatory Stress in an In Vitro Fluid-Dynamic\nModel"],"prefix":"10.1021","volume":"11","author":[{"given":"Sonakshi","family":"Puri","sequence":"first","affiliation":[{"name":"Birla Institute of Technology and Science Pilani, Pilani Campus , , , ,","place":["Pilani, Rajasthan, India, 333031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit Kumar","family":"Mandal","sequence":"additional","affiliation":[{"name":"Birla Institute of Technology and Science Pilani, Pilani Campus , , , ,","place":["Pilani, Rajasthan, India, 333031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-4628","authenticated-orcid":true,"given":"Pankaj Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Birla Institute of Technology and Science Pilani, Pilani Campus , , , ,","place":["Pilani, Rajasthan, India, 333031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3680-1577","authenticated-orcid":true,"given":"Murugesan","family":"Sankaranarayanan","sequence":"additional","affiliation":[{"name":"Birla Institute of Technology and Science Pilani, Pilani Campus , , , ,","place":["Pilani, Rajasthan, India, 333031"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9165-5923","authenticated-orcid":true,"given":"Perinkulam Ravi","family":"Deepa","sequence":"additional","affiliation":[{"name":"Birla Institute of Technology and Science Pilani, Pilani Campus , , , ,","place":["Pilani, Rajasthan, India, 333031"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"issue":"1","key":"2026072810093932000_cit1","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1097\/TP.0000000000002480","article-title":"Nonalcoholic Fatty Liver Disease: Basic Pathogenetic\nMechanisms in the Progression from NAFLD to NASH","volume":"103","author":"Pierantonelli","year":"2019","journal-title":"Transplantation"},{"issue":"11","key":"2026072810093932000_cit2","first-page":"697","article-title":"Examining\nthe Nomenclature Change from NAFLD and NASH to MASLD and MASH","volume":"19","author":"Rinella","year":"2023","journal-title":"Gastroenterol. Hepatol."},{"key":"2026072810093932000_cit3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/dom.70662","article-title":"Current Trends in the Epidemiology\nof Obesity and the Association Between Obesity and Metabolic Liver\nDisease (MASLD\/MASH)","volume":"28","author":"Grocic","year":"2026","journal-title":"Diabetes, Obes. Metab"},{"key":"2026072810093932000_cit4","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1007\/s10620-025-09498-7","article-title":"Systematic Mapping of Worldwide Research on Metabolic Dysfunction-Associated\nSteatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated\nSteatohepatitis (MASH)","volume":"71","author":"Silva","year":"2025","journal-title":"Dig. Dis. Sci."},{"issue":"1","key":"2026072810093932000_cit5","doi-asserted-by":"publisher","first-page":"7083","DOI":"10.1038\/s41598-025-91312-5","article-title":"Global Burden\nof MAFLD, MAFLD Related Cirrhosis and MASH Related Liver Cancer from\n1990 to 2021","volume":"15","author":"Guo","year":"2025","journal-title":"Sci. Rep."},{"issue":"S1","key":"2026072810093932000_cit6","doi-asserted-by":"publisher","first-page":"S99","DOI":"10.1002\/hep.20973","article-title":"Nonalcoholic Fatty Liver Disease:\nFrom Steatosis to\nCirrhosis","volume":"43","author":"Farrell","year":"2006","journal-title":"Hepatology"},{"issue":"1","key":"2026072810093932000_cit7","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/hep.21221","article-title":"Favored T Helper\n1 Response in a Mouse Model of Hepatosteatosis Is Associated with\nEnhanced T Cell\u2013Mediated Hepatitis","volume":"44","author":"Kremer","year":"2006","journal-title":"Hepatology"},{"issue":"4","key":"2026072810093932000_cit8","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.immuni.2008.03.004","article-title":"The Biological\nFunctions of T Helper\n17 Cell Effector Cytokines in Inflammation","volume":"28","author":"Ouyang","year":"2008","journal-title":"Immunity"},{"issue":"1","key":"2026072810093932000_cit9","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ajpath.2012.03.044","article-title":"Th17 Cells: Biology,\nPathogenesis of Autoimmune and Inflammatory Diseases, and Therapeutic\nStrategies","volume":"181","author":"Maddur","year":"2012","journal-title":"Am. J. Pathol."},{"issue":"1","key":"2026072810093932000_cit10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/345803","article-title":"Role of IL-17\nand Th17 Cells in Liver\nDiseases","volume":"2011","author":"Hammerich","year":"2011","journal-title":"Clin. Dev. Immunol."},{"issue":"5","key":"2026072810093932000_cit11","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/j.jhep.2019.12.016","article-title":"IL-17\nSignaling in Steatotic Hepatocytes and Macrophages\nPromotes Hepatocellular Carcinoma in Alcohol-Related Liver Disease","volume":"72","author":"Ma","year":"2020","journal-title":"J. Hepatol."},{"issue":"01","key":"2026072810093932000_cit12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1055\/s-2006-927395","article-title":"Inflammation, Damage Repair and Liver\nFibrosis-Role\nof Cytokines and Different Cell Types","volume":"45","author":"Saile","year":"2007","journal-title":"Z. Gastroenterol."},{"issue":"23","key":"2026072810093932000_cit13","doi-asserted-by":"publisher","first-page":"25094","DOI":"10.1021\/acsomega.4c02433","article-title":"In Vitro\nNonalcoholic Fatty Liver Disease Model Elucidating the Effect of Immune\nEnvironment on Disease Progression and Alleviation","volume":"9","author":"Kim","year":"2024","journal-title":"ACS Omega"},{"key":"2026072810093932000_cit14","doi-asserted-by":"publisher","first-page":"115157","DOI":"10.1016\/j.bcp.2022.115157","article-title":"Ceramide de Novo Synthesis in Non-Alcoholic\nFatty Liver\nDisease: Pathogenic Mechanisms and Therapeutic Perspectives","volume":"202","author":"Yu","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"2026072810093932000_cit15","doi-asserted-by":"publisher","first-page":"100346","DOI":"10.1016\/j.jhepr.2021.100346","article-title":"New Targets for NAFLD","volume":"3","author":"Parlati","year":"2021","journal-title":"JHEP Rep."},{"issue":"22","key":"2026072810093932000_cit16","doi-asserted-by":"publisher","first-page":"5594","DOI":"10.3390\/ijms20225594","article-title":"Lipid Related\nGenes Altered in NASH Connect Inflammation\nin Liver Pathogenesis Progression to HCC: A Canonical Pathway","volume":"20","author":"Desterke","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2026072810093932000_cit17","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/978-981-10-8684-7_3","article-title":"Pathogenesis\nof NASH: How Metabolic\nComplications of Overnutrition Favour Lipotoxicity and pro-Inflammatory\nFatty Liver Disease","volume":"1061","author":"Farrell","year":"2018","journal-title":"Obesity, Fat. Liver Liver\nCancer"},{"key":"2026072810093932000_cit18","doi-asserted-by":"publisher","first-page":"581723","DOI":"10.3389\/fnut.2020.581723","article-title":"Maternal High-Fat Diet Leads to Non-Alcoholic\nFatty Liver Disease through Upregulating Hepatic SCD1 Expression in\nNeonate Rats","volume":"7","author":"Cao","year":"2020","journal-title":"Front. Nutr."},{"issue":"1","key":"2026072810093932000_cit19","doi-asserted-by":"publisher","first-page":"46658","DOI":"10.1038\/srep46658","article-title":"Metabolism Dysregulation\nInduces a Specific Lipid Signature of Nonalcoholic Steatohepatitis\nin Patients","volume":"7","author":"Chiappini","year":"2017","journal-title":"Sci. Rep."},{"key":"2026072810093932000_cit20","doi-asserted-by":"publisher","first-page":"47022","DOI":"10.1021\/acsomega.5c05345","article-title":"Targeting Stearoyl-CoA Desaturase-1 (SCD1) by the Drug\u2013Nutraceutical\nCombination of Montelukast and Bixin in Ameliorating Steatotic NAFLD","volume":"10","author":"Puri","year":"2025","journal-title":"ACS Omega"},{"key":"2026072810093932000_cit21","unstructured":"Habboubi, B.\n          \n          Bixa Orellana\nL. Pods and Seeds: Nutritional and Chemical Characterization, Bioactivity\nStudies, and Development of a Carotenoid-Based Food Colorant. Master\u2019s thesis, Instituto Politecnico de\nBraganca (Portugal)2020."},{"key":"2026072810093932000_cit22","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.neuropharm.2014.01.011","article-title":"Montelukast Targeting\nthe Cysteinyl Leukotriene Receptor 1 Ameliorates A\u03b21\u201342-Induced\nMemory Impairment and Neuroinflammatory and Apoptotic Responses in\nMice","volume":"79","author":"Lai","year":"2014","journal-title":"Neuropharmacology"},{"issue":"6","key":"2026072810093932000_cit23","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s40265-024-02045-0","article-title":"Resmetirom:\nFirst Approval","volume":"84","author":"Keam","year":"2024","journal-title":"Drugs"},{"issue":"10","key":"2026072810093932000_cit24","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1038\/s41591-021-01495-3","article-title":"Aramchol in Patients\nwith Nonalcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled\nPhase 2b Trial","volume":"27","author":"Ratziu","year":"2021","journal-title":"Nat. Med."},{"key":"2026072810093932000_cit25","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/liv.14844","article-title":"New Drugs for NASH","volume":"41","author":"Albhaisi","year":"2021","journal-title":"Liver Int."},{"issue":"2","key":"2026072810093932000_cit26","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/j.1365-2249.2011.04471.x","article-title":"Interleukin-17\nExacerbates Hepatic Steatosis and Inflammation in Non-Alcoholic Fatty\nLiver Disease","volume":"166","author":"Tang","year":"2011","journal-title":"Clin. Exp. Immunol."},{"issue":"3","key":"2026072810093932000_cit27","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1007\/s11030-023-10666-y","article-title":"Targeting Lipid-Sensing\nNuclear Receptors PPAR (\u03b1, \u03b3, \u03b2\/\u03b4): HTVS and\nMolecular Docking\/Dynamics Analysis of Pharmacological Ligands as\nPotential Pan-PPAR Agonists","volume":"28","author":"Mandal","year":"2024","journal-title":"Mol. Divers."},{"issue":"8","key":"2026072810093932000_cit28","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.jsps.2018.07.006","article-title":"Ginkgolide\nC Reduced Oleic Acid-Induced Lipid Accumulation in HepG2 Cells","volume":"26","author":"Huang","year":"2018","journal-title":"Saudi Pharm. J."},{"issue":"1","key":"2026072810093932000_cit29","doi-asserted-by":"publisher","first-page":"26995","DOI":"10.1038\/s41598-025-12357-0","article-title":"In Silico and in Vitro Investigations\nReveal Pan-PPAR\nAgonist Activity and Anti-NAFLD Efficacy of Polydatin by Modulating\nHepatic Lipid-Energy Metabolism","volume":"15","author":"Mandal","year":"2025","journal-title":"Sci. Rep."},{"issue":"40","key":"2026072810093932000_cit30","doi-asserted-by":"publisher","first-page":"405201","DOI":"10.1088\/1361-6463\/ad5c71","article-title":"Biochemical\nEvaluation\nof Wound Healing Efficacy of Cold Plasma-Conditioned Media under Different\nOperational Conditions","volume":"57","author":"Puri","year":"2024","journal-title":"J. Phys. D. Appl. Phys."},{"key":"2026072810093932000_cit31","doi-asserted-by":"publisher","first-page":"1616796","DOI":"10.3389\/fcimb.2025.1616796","article-title":"The Effect\nof Massa Medicata Fermentata\non the Cytokine Secretion of Colonic Mucosa and Visceral Sensitivity\nin Rats with IBS-D","volume":"15","author":"Zhuang","year":"2026","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"5","key":"2026072810093932000_cit32","doi-asserted-by":"publisher","first-page":"158905","DOI":"10.1016\/j.bbalip.2021.158905","article-title":"Chronic Systemic\nExposure to IL6 Leads to Deregulation of Glycolysis and Fat Accumulation\nin the Zebrafish Liver","volume":"1866","author":"Singh","year":"2021","journal-title":"Biochim. Biophys. Acta\n- Mol. Cell Biol. Lipids"},{"issue":"5","key":"2026072810093932000_cit33","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1002\/hep.26746","article-title":"IL-17 Signaling Accelerates\nthe Progression of Nonalcoholic Fatty Liver Disease in Mice","volume":"59","author":"Harley","year":"2014","journal-title":"Hepatology"},{"issue":"5","key":"2026072810093932000_cit34","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1002\/hep.24001","article-title":"Evolution of Inflammation in Nonalcoholic Fatty Liver\nDisease: The Multiple Parallel Hits Hypothesis","volume":"52","author":"Tilg","year":"2010","journal-title":"Hepatology"},{"issue":"May","key":"2026072810093932000_cit35","doi-asserted-by":"publisher","first-page":"174295","DOI":"10.1016\/j.ejphar.2021.174295","article-title":"The Leukotriene\nReceptor Antagonist Montelukast in the Treatment of Non-Alcoholic\nSteatohepatitis: A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled\nTrial","volume":"906","author":"Abdallah","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"2026072810093932000_cit36","doi-asserted-by":"publisher","first-page":"6610124","DOI":"10.1155\/2021\/6610124","article-title":"Bixin Attenuates\nHigh-Fat Diet-Caused Liver Steatosis and Inflammatory Injury through\nNrf2\/PPAR\u03b1 Signals","volume":"2021","author":"Tao","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"2026072810093932000_cit37","doi-asserted-by":"publisher","first-page":"105612","DOI":"10.1016\/j.fitote.2023.105612","article-title":"The Role\nof Bixin as Antioxidant, Anti-Inflammatory, Anticancer, and Skin Protecting\nNatural Product Extracted from Bixa Orellana L","volume":"169","author":"Ashraf","year":"2023","journal-title":"Fitoterapia"},{"issue":"4","key":"2026072810093932000_cit38","doi-asserted-by":"publisher","DOI":"10.2174\/0115734072265200230925062619","article-title":"Nanoencapsulation of Bixin and Norbixin\nin Sodium Alginate: Preparation, Characterization, and Release in\nFood Simulant","volume":"20","author":"Savazzi","year":"2024","journal-title":"Curr. Bioact. Compd."},{"issue":"3","key":"2026072810093932000_cit39","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1046\/j.1365-2222.2003.01615.x","article-title":"Anti-inflammatory Effects of High-dose\nMontelukast in an Animal Model\nof Acute Asthma","volume":"33","author":"Wu","year":"2003","journal-title":"Clin. Exp. Allergy"},{"issue":"7","key":"2026072810093932000_cit40","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.2337\/dc22-2048","article-title":"High Prevalence\nof NASH\nand Advanced Fibrosis in Type 2 Diabetes: A Prospective Study of 330\nOutpatients Undergoing Liver Biopsies for Elevated ALT, Using a Low\nThreshold","volume":"46","author":"Castera","year":"2023","journal-title":"Diabetes Care"},{"issue":"1","key":"2026072810093932000_cit41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/5805398","article-title":"Liver Protective Effect\nof Fenofibrate in NASH\/NAFLD Animal Models","volume":"2022","author":"Mahmoudi","year":"2022","journal-title":"PPAR Res."},{"issue":"20","key":"2026072810093932000_cit42","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.90954","article-title":"Development of an in\nVitro Human Liver System for Interrogating Nonalcoholic\nSteatohepatitis","volume":"1","author":"Feaver","year":"2016","journal-title":"JCI insight"},{"key":"2026072810093932000_cit43","doi-asserted-by":"publisher","first-page":"117046","DOI":"10.1016\/j.taap.2024.117046","article-title":"A Preclinical Model of Severe NASH-like\nLiver Injury by Chronic Administration of a High-Fat and High-Sucrose\nDiet in Mice","volume":"491","author":"Willett","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"4","key":"2026072810093932000_cit44","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1111\/j.1440-1746.2010.06509.x","article-title":"Non-alcoholic Fatty\nLiver Disease\u2019s\nPrevalence and Impact on Alanine Aminotransferase Associated with\nMetabolic Syndrome in the Chinese","volume":"26","author":"Hou","year":"2011","journal-title":"J. Gastroenterol.\nHepatol."},{"issue":"4","key":"2026072810093932000_cit45","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.4049\/jimmunol.1203013","article-title":"IL-17A Plays\na Critical Role in the Pathogenesis of Liver Fibrosis through Hepatic\nStellate Cell Activation","volume":"191","author":"Tan","year":"2013","journal-title":"J. Immunol."},{"issue":"6","key":"2026072810093932000_cit46","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00011-017-1029-3","article-title":"HCV-Induced\nRegulatory Alterations of IL-1\u03b2, IL-6, TNF-\u03b1, and IFN-\u03d2\nOperative, Leading Liver En-Route to Non-Alcoholic Steatohepatitis","volume":"66","author":"Nawaz","year":"2017","journal-title":"Inflamm. Res."},{"issue":"6","key":"2026072810093932000_cit47","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1111\/j.1572-0241.2007.01774.x","article-title":"Increased Hepatic and Circulating\nInterleukin-6 Levels\nin Human Nonalcoholic Steatohepatitis","volume":"103","author":"Wieckowska","year":"2008","journal-title":"Off.\nJ. Am. Coll. Gastroenterol. ACG"},{"key":"2026072810093932000_cit48","doi-asserted-by":"publisher","first-page":"114931","DOI":"10.1016\/j.taap.2020.114931","article-title":"Montelukast\nAmeliorates Concanavalin A-Induced Autoimmune\nHepatitis in Mice via Inhibiting TNF-\u03b1\/JNK Signaling Pathway","volume":"393","author":"El-Kashef","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2026072810093932000_cit49","doi-asserted-by":"publisher","first-page":"593368","DOI":"10.3389\/fimmu.2020.593368","article-title":"Bixin Attenuates\nExperimental Autoimmune Encephalomyelitis by Suppressing TXNIP\/NLRP3\nInflammasome Activity and Activating NRF2 Signaling","volume":"11","author":"Yu","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"2026072810093932000_cit50","doi-asserted-by":"publisher","first-page":"9396425","DOI":"10.1155\/2017\/9396425","article-title":"Resveratrol and Montelukast Alleviate\nParaquat-induced Hepatic Injury in Mice: Modulation of Oxidative Stress,\nInflammation, and Apoptosis","volume":"2017","author":"El-Boghdady","year":"2017","journal-title":"Oxid. Med. Cell.\nLongev."},{"issue":"43","key":"2026072810093932000_cit51","doi-asserted-by":"publisher","first-page":"31797","DOI":"10.1039\/D4RA06037G","article-title":"Lipogenic Stearoyl-CoA Desaturase-1\n(SCD1) Targeted Virtual Screening for Chemical Inhibitors: Molecular\nDocking\/Dynamics Simulation and in Vitro Assessment of Anti-NAFLD\nEfficacy","volume":"14","author":"Puri","year":"2024","journal-title":"RSC Adv."},{"issue":"1","key":"2026072810093932000_cit52","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s11154-016-9339-2","article-title":"The Role of Immune Cells in Metabolism-Related Liver\nInflammation and Development of Non-Alcoholic Steatohepatitis (NASH)","volume":"17","author":"Nati","year":"2016","journal-title":"Rev. Endocr. Metab. 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