{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:10:19Z","timestamp":1790698219686,"version":"4.1.0"},"reference-count":93,"publisher":"American Chemical Society (ACS)","issue":"38","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007382","name":"Universidade Federal do Par?","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["305150\/2022-7"],"award-info":[{"award-number":["305150\/2022-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["307774\/2025-2"],"award-info":[{"award-number":["307774\/2025-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["309092\/2026-4"],"award-info":[{"award-number":["309092\/2026-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sustainable extraction of bioactive compounds from Amazonian fruits is essential for green chemistry, but integrated kinetic, thermodynamic, economic, and sustainability assessments for Myrciaria dubia (camu\u2013camu) phenolics remain limited. This study investigated phenolic extraction from camu\u2013camu pulp using natural deep eutectic solvents (NADES) composed of choline chloride and acetic acid, either pure or in binary mixtures with water or ethanol (EtOH), combined with conventional (CE), shear (SE), and ultrasound-assisted extraction (UAE; 420, 490, 560 W). Extraction kinetics, mass transfer parameters, thermodynamics, environmental performance (EcoScale and AGREE metrics), and preliminary economics were evaluated. UAE using NADES + EtOH at 560 W yielded the highest phenolic content (17.11 mg GAE\/g). Fick\u2019s diffusion model best described the kinetics (R2 &amp;gt; 0.9523), indicating a diffusion-controlled process, while thermodynamic analysis confirmed an endothermic and spontaneous process. All DES-based systems showed superior environmental performance over CE using 70% (v\/v) EtOH, with EcoScale scores of 87.97\u201392.97 (vs 83.43) and AGREE values of 0.61 (vs 0.52). Preliminary economic assessment indicated extract production costs of US$ 1.83\u20132.26\/kg; NADES-based systems maintained competitive costs while providing higher phenolic content than conventional extraction. Combining NADES + EtOH and UAE represents a promising strategy for enhancing phenolic recovery while maintaining favorable sustainability and economic performance, supporting greener extraction of Amazonian resources.<\/jats:p>","DOI":"10.1021\/acsomega.6c02599","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:01:28Z","timestamp":1789732888000},"page":"56818-56834","source":"Crossref","is-referenced-by-count":0,"title":["Extraction of Phenolic Compounds from the Pulp of\n                    <i>Myrciaria dubia<\/i>\n                    Using Eco-Friendly Solvents: Extraction\nKinetics and Determination of Mass Transfer and Thermodynamic Parameters"],"prefix":"10.1021","volume":"11","author":[{"given":"Andre\u0301","family":"Gomes Mesquita","sequence":"first","affiliation":[{"name":"Universidade Federal do Para , , ,","place":["Para, Brazil, 66075-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriny dos Santos Miranda","family":"Lobato","sequence":"additional","affiliation":[{"name":"Universidade Federal do Para , , ,","place":["Para, Brazil, 66075-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iane Valente","family":"Pires","sequence":"additional","affiliation":[{"name":"Universidade Federal do Para , , ,","place":["Para, Brazil, 66075-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6002-9425","authenticated-orcid":true,"given":"Luiza Helena","family":"Meller da Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Para , , ,","place":["Para, Brazil, 66075-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Manoel","family":"da Cruz Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Federal do Para , , ,","place":["Para, Brazil, 66075-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"2026092911083933200_cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.131290","article-title":"Camu-Camu\n[Myrciaria Dubia (HBK) McVaugh]: A Review of Properties and Proposals\nof Products for Integral Valorization of Raw Material","volume":"372","author":"Santos","year":"2022","journal-title":"Food Chem."},{"issue":"12","key":"2026092911083933200_cit2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202200864","article-title":"Myrciaria Genus: Bioactive Compounds\nand Biological Activities","volume":"19","author":"Pereira","year":"2022","journal-title":"Chem. Biodivers."},{"key":"2026092911083933200_cit3","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/B978-0-12-816911-7.00017-7","article-title":"Extraction with\nIonic Liquids-Organic Compounds","volume-title":"Liquid-Phase\nExtraction","author":"Pacheco-Ferna\u0301ndez","year":"2020"},{"issue":"1","key":"2026092911083933200_cit4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ecofro.2024.09.008","article-title":"A Review\non the Composition, Extraction and Applications of Phenolic Compounds","volume":"45","author":"Edo","year":"2025","journal-title":"Ecol. Front."},{"key":"2026092911083933200_cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2019.06.004","article-title":"High Shear-Assisted\nSolvent Extraction of Lipid from Wet Biomass of Aurantiochytrium Sp.\nKRS101","volume":"227","author":"Kwak","year":"2019","journal-title":"Sep. Purif. 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Character."},{"key":"2026092911083933200_cit27","doi-asserted-by":"publisher","DOI":"10.3389\/fsufs.2024.1375076","article-title":"Natural Deep\nEutectic Liquid and Ultrasound-Assisted Extraction of Milk Thistle\nPhenolics and Their Hepatoprotective Activities","volume":"8","author":"Nasrullah","year":"2024","journal-title":"Front. Sustainable Food Syst."},{"key":"2026092911083933200_cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2025.132577","article-title":"Ethanol-Driven\nBifunctional Deep Eutectic Solvents for Efficient in Situ Selective\nRecovery of Valuable Metals from Spent Lithium Batteries","volume":"364","author":"Su","year":"2025","journal-title":"Sep. Purif. Technol."},{"key":"2026092911083933200_cit29","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ifset.2018.07.001","article-title":"Extraction of Phenolic Compounds\nfrom Olive Pomace by Using Natural\nDeep Eutectic Solvents and Innovative Extraction Techniques","volume":"48","author":"Chanioti","year":"2018","journal-title":"Innovative Food Sci. Emerging Technol."},{"issue":"11","key":"2026092911083933200_cit30","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11112295","article-title":"Conventional\nvs. Green Extraction Using Natural Deep\nEutectic Solvents \u2500 Differences in the Composition of Soluble\nUnbound Phenolic Compounds and Antioxidant Activity","volume":"11","author":"Martinovic\u0301","year":"2022","journal-title":"Antioxidants"},{"issue":"1","key":"2026092911083933200_cit31","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s11696-021-01862-x","article-title":"Green Extraction of Flavonoids and\nPhenolic Acids from Elderberry (Sambucus Nigra L.) and Rosemary (Rosmarinus\nOfficinalis L.) Using Deep Eutectic Solvents","volume":"76","author":"Vladimir-Knez\u030cevic\u0301","year":"2022","journal-title":"Chem. Pap."},{"key":"2026092911083933200_cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.scp.2021.100375","article-title":"Choline Chloride-Based\nDeep Eutectic Solvents Do Not Improve the Ethanolic Extraction of\nCarotenoids from Buriti Fruit (Mauritia Flexuosa L.)","volume":"20","author":"Leite","year":"2021","journal-title":"Sustainable Chem. Pharm."},{"issue":"15","key":"2026092911083933200_cit33","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1002\/cssc.202000286","article-title":"Modeling the\nPhysicochemical Properties of Natural Deep Eutectic Solvents","volume":"13","author":"Kova\u0301cs","year":"2020","journal-title":"ChemSusChem"},{"issue":"3","key":"2026092911083933200_cit34","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s13203-021-00282-y","article-title":"Evaluation\nof Hybrid Solvents Featuring\nCholine Chloride-Based Deep Eutectic Solvents and Ethanol as Extractants\nfor the Liquid\u2013Liquid Extraction of Benzene from n-Hexane:\nTowards a Green and Sustainable Paradigm","volume":"11","author":"Usman","year":"2021","journal-title":"Appl.\nPetrochem. Res."},{"key":"2026092911083933200_cit35","volume-title":"Perry\u2019s Chemical\nEngineers\u2019 Handbook","author":"Green","year":"2019"},{"key":"2026092911083933200_cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.122767","article-title":"Influence of Physicochemical\nProperties of Carboxylic Acid-Based Natural Deep Eutectic Solvents\n(CA-NADES) on Extraction and Stability of Bioactive Compounds from\nDate (Phoenix Dactylifera L.) Seeds: An Innovative and Sustainable\nExtraction Technique","volume":"388","author":"Airouyuwa","year":"2023","journal-title":"J. Mol. Liq."},{"issue":"6","key":"2026092911083933200_cit37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23063381","article-title":"Deep Eutectic Solvent\nas Green Solvent in Extraction\nof Biological Macromolecules: A Review","volume":"23","author":"Ling","year":"2022","journal-title":"Int.\nJ. Mol. 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Biorefin."},{"key":"2026092911083933200_cit39","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.fluid.2019.01.025","article-title":"Influence\nof Temperature, Water Content and Type of Organic Acid on the Formation,\nStability and Properties of Functional Natural Deep Eutectic Solvents","volume":"488","author":"Savi","year":"2019","journal-title":"Fluid Phase Equilib."},{"key":"2026092911083933200_cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2025.128414","article-title":"Physicochemical Properties, Antioxidant\nPotential, and Spectroscopic Investigation of Choline Chloride\u2013Lactic\nAcid NADES: Effects of Molar Ratio and Added Water","volume":"437","author":"Pires","year":"2025","journal-title":"J. Mol. Liq."},{"issue":"28","key":"2026092911083933200_cit41","doi-asserted-by":"publisher","first-page":"6281","DOI":"10.1021\/acs.jpca.5c02940","article-title":"Energetic\nOrigins of the Hydrogen-Bond\nRedshift: IQA Partitioning of Normal Mode Force Constants","volume":"129","author":"Duarte","year":"2025","journal-title":"J. Phys. Chem. A"},{"key":"2026092911083933200_cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2020.122787","article-title":"Structural,\nElectronic, and Vibrational Properties\nof Choline Halides","volume":"246","author":"Zhuravlev","year":"2020","journal-title":"Mater. Chem. Phys."},{"key":"2026092911083933200_cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2024.125314","article-title":"Unveiling\nthe Potential of Acetic Acid-Based Hydrophobic Natural Deep Eutectic\nSolvents for Phytochemical Extraction","volume":"408","author":"Srivastava","year":"2024","journal-title":"J. Mol.\nLiq."},{"key":"2026092911083933200_cit44","volume-title":"Spectrometric\nIdentification of Organic Compounds","author":"Silverstein","year":"2014","edition":"8"},{"issue":"12","key":"2026092911083933200_cit45","doi-asserted-by":"publisher","first-page":"4643","DOI":"10.1039\/c0cs00014k","article-title":"Light at the\nInterface: The Potential\nof Attenuated Total Reflection Infrared Spectroscopy for Understanding\nHeterogeneous Catalysis in Water","volume":"39","author":"Mojet","year":"2010","journal-title":"Chem. Soc.\nRev."},{"issue":"4","key":"2026092911083933200_cit46","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1063\/1.3114588","article-title":"Investigation\nof Dynamic Glass Transitions and Structural Transformations in Cryovacuum\nCondensates of Ethanol","volume":"35","author":"Aldiyarov","year":"2009","journal-title":"Low Temp. 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Acta, Part A"},{"issue":"41","key":"2026092911083933200_cit52","doi-asserted-by":"publisher","first-page":"38243","DOI":"10.1021\/acsomega.3c04570","article-title":"Elucidating the\nStructure, Dynamics, and Interaction of a Choline Chloride and Citric\nAcid Based Eutectic System by Spectroscopic and Molecular Modeling\nInvestigations","volume":"8","author":"Ali","year":"2023","journal-title":"ACS Omega"},{"key":"2026092911083933200_cit53","volume-title":"Unit Operations of Chemical\nEngineering","author":"McCabe","year":"1993","edition":"5"},{"issue":"1","key":"2026092911083933200_cit54","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95769-y","article-title":"Effect of Particle Size on Phytochemical\nComposition\nand Antioxidant Properties of Sargassum Cristaefolium Ethanol Extract","volume":"11","author":"Prasedya","year":"2021","journal-title":"Sci. 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