{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:32:43Z","timestamp":1790821963803,"version":"4.1.0"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"24","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010854","name":"Jiangsu Provincial Commission of Health and Family Planning","doi-asserted-by":"publisher","award":["M2021012"],"award-info":[{"award-number":["M2021012"]}],"id":[{"id":"10.13039\/501100010854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172354"],"award-info":[{"award-number":["82172354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472333"],"award-info":[{"award-number":["82472333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Affiliated Drum Tower Hospital, Medical School of Nanjing University","award":["2022-LCYJ-MS-02"],"award-info":[{"award-number":["2022-LCYJ-MS-02"]}]},{"name":"Affiliated Drum Tower Hospital, Medical School of Nanjing University","award":["XJSFZLX202331"],"award-info":[{"award-number":["XJSFZLX202331"]}]},{"name":"Nanjing Medical Science and Technology Development Foundation","award":["ZKX22013"],"award-info":[{"award-number":["ZKX22013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Omega"],"published-print":{"date-parts":[[2026,6,23]]},"DOI":"10.1021\/acsomega.6c02666","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:56:04Z","timestamp":1780923364000},"page":"35903-35912","source":"Crossref","is-referenced-by-count":1,"title":["Characterization of the Anti-Alzheimer Drug Lecanemab by Mass Spectrometry"],"prefix":"10.1021","volume":"11","author":[{"given":"Jiaojiao","family":"Sha","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine","place":["Nanjing, China"]},{"name":"Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijin","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine","place":["Nanjing, China"]},{"name":"Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanyu","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine","place":["Nanjing, China"]},{"name":"Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangjia","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine","place":["Nanjing, China"]},{"name":"Nanjing Drum Tower Hospital Clinical College of Nanjing Normal University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine","place":["Nanjing, China"]},{"name":"Nanjing Drum Tower Hospital Clinical College of Nanjing Normal University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minqi","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","place":["Nanjing, China"]},{"name":"Nanjing University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","place":["Nanjing, China"]},{"name":"Nanjing University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Precision Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","place":["Nanjing, China"]},{"name":"Nanjing University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Precision Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","place":["Nanjing, China"]},{"name":"Nanjing University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","place":["Nanjing, China"]},{"name":"Nanjing University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6715-2553","authenticated-orcid":true,"given":"Tianze","family":"Ling","sequence":"additional","affiliation":[{"name":"School of Life Sciences","place":["Beijing, China"]},{"name":"Tsinghua University","place":["Beijing, China"]},{"name":"State Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing)","place":["Beijing, China"]},{"name":"Research Unit of Proteomics-driven Cancer Precision Medicine (Chinese Academy of Medical Sciences)","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0361-2438","authenticated-orcid":true,"given":"Cheng","family":"Chang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing)","place":["Beijing, China"]},{"name":"Research Unit of Proteomics-driven Cancer Precision Medicine (Chinese Academy of Medical Sciences)","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1505-2965","authenticated-orcid":true,"given":"Bing","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine","place":["Nanjing, China"]},{"name":"Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"name":"Department of Laboratory Medicine","place":["Nanjing, China"]},{"name":"Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University","place":["Nanjing, China"]},{"name":"Department of Laboratory Medicine","place":["Nanjing, China"]},{"name":"Nanjing Drum Tower Hospital Clinical College of Nanjing Normal University","place":["Nanjing, China"]},{"name":"Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","place":["Nanjing, China"]},{"name":"Nanjing University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00269-y"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00520-w"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2967"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01249-0"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-021-00533-w"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01024-z"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-023-00789-z"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104511"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00404-2"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2210766119"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-022-00645-6"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01484-7"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1177\/10600280231218253"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2023.2178414"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04759.x"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-023-00030-3"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1126\/science.adg6275"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.24490"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1126\/science.adk0830"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-023-01331-1"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1177\/13872877241307246"},{"key":"ref24\/cit24","volume-title":"Monoclonal Antibodies Physicochemical Analysis","author":"Kaur H.","year":"2021"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2019.08.009"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.3390\/antib8040055"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-025-02125-8"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4256"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17921-y"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky869"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1081"},{"key":"ref32\/cit32","volume-title":"Monoclonal Antibodies Physicochemical Analysis","author":"Graf T.","year":"2021"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2022.339828"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21504"},{"key":"ref35\/cit35","volume-title":"Physicochemical Characterization of Monoclonal Antibodies","author":"Gst\u00f6ttner C.","year":"2021"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.R112.026005"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-026-01207-0"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","DOI":"10.1021\/bk-2015-1201.ch003","volume-title":"Structural Elucidation of Post-Translational Modifications in Monoclonal Antibodies","author":"Li W.","year":"2015"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-014-8108-x"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3390\/antib12040083"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.2c00027"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c02666","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c02666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:29:59Z","timestamp":1782206999000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsomega.6c02666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":41,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2026,6,23]]}},"alternative-id":["10.1021\/acsomega.6c02666"],"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c02666","relation":{},"ISSN":["2470-1343","2470-1343"],"issn-type":[{"value":"2470-1343","type":"print"},{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]}}}