{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:02:28Z","timestamp":1785250948427,"version":"3.55.0"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"29","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00958-21"],"award-info":[{"award-number":["APQ-00958-21"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda??o de Amparo ? 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CHIKV and MAYV, which are both members of the genus Alphavirus, represent a growing public health concern in Brazil. This is owing to rising arboviral infections and the potential for cotransmission by shared urban vectors. Effective control requires integrated strategies, including antivirals. Therefore, this study evaluated the cytotoxicity, antiviral activity, and in silico pharmacokinetic\/toxicological profiles of nine structurally diverse compounds. Accordingly, procyanidins A2 (PA2), C1 (PC1), and genistein (GNT) displayed the most promising antiviral activity against CHIKV. Moreover, these compounds exhibited selectivity index (SI) values of 5.9, 10.4, and 2.6, with half maximal effective concentrations of 56.7, 50.2, and 64.4 \u03bcM, respectively. Furthermore, for the anti-MAYV activity, PA2 and PC1 exhibited SI values of 4.1 and 61, with EC50 values of 81.7 and 8.8 \u03bcM, respectively. In addition, GNT induced a 5-log reduction of CHIKV replication, whereas PC1 caused a 4-log reduction of MAYV replication. In virucidal assays, PA2 and PC1 nearly abolished (\u223c100%) CHIKV infectivity and reduced MAYV infectivity by approximately 80%.In silico analysis indicated that GNT had favorable pharmacokinetics and high toxicological safety, whereas PC1 demonstrated strong safety despite limited oral bioavailability. These results identify PC1 as the most promising candidate for future preclinical development, whereas GNT and PA2 should be considered lead compounds for further optimization strategies aimed at improving selectivity and safety profiles.<\/jats:p>","DOI":"10.1021\/acsomega.6c02683","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:14:58Z","timestamp":1784175298000},"page":"43669-43681","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Antiviral Activity of Monomeric,\nDimeric, and Oligomeric Flavonoids against Chikungunya and Mayaro\nViruses"],"prefix":"10.1021","volume":"11","author":[{"given":"Delaine Meireles","family":"Gouve\u0302a","sequence":"first","affiliation":[{"name":"Universidade Federal de Sa\u0303o Joa\u0303o del-Rei Campus Alto Paraopeba , , Rod. MG 443, KM 7 Fazenda do Cadete , , ,","place":["Ouro Branco, Minas Gerais, Brazil, CEP: 36495-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ceci\u0301lia Muniz de Souza","family":"Brand","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sa\u0303o Joa\u0303o del-Rei Campus Alto Paraopeba , , Rod. MG 443, KM 7 Fazenda do Cadete , , ,","place":["Ouro Branco, Minas Gerais, Brazil, CEP: 36495-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Millena Alves Ma\u0301ximo","family":"Vaz","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sa\u0303o Joa\u0303o del-Rei Campus Alto Paraopeba , , Rod. MG 443, KM 7 Fazenda do Cadete , , ,","place":["Ouro Branco, Minas Gerais, Brazil, CEP: 36495-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Gonc\u0327alves","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sa\u0303o Joa\u0303o del-Rei Campus Alto Paraopeba , , Rod. MG 443, KM 7 Fazenda do Cadete , , ,","place":["Ouro Branco, Minas Gerais, Brazil, CEP: 36495-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius","family":"Viana","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sa\u0303o Joa\u0303o del-Rei Campus Alto Paraopeba , , Rod. MG 443, KM 7 Fazenda do Cadete , , ,","place":["Ouro Branco, Minas Gerais, Brazil, CEP: 36495-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilly Soares","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sa\u0303o Joa\u0303o del-Rei Campus Alto Paraopeba , , Rod. MG 443, KM 7 Fazenda do Cadete , , ,","place":["Ouro Branco, Minas Gerais, Brazil, CEP: 36495-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Coelho Ferraz","sequence":"additional","affiliation":[{"name":"Campus Universita\u0301rio, Morro do Cruzeiro , , s\/n, Vila Itacolomi , , ,","place":["Ouro Preto, Minas Gerais, Brazil, CEP: 35400-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Cotta Cardoso","family":"Reis","sequence":"additional","affiliation":[{"name":"Campus Universita\u0301rio, Morro do Cruzeiro , , s\/n, Vila Itacolomi , , ,","place":["Ouro Preto, Minas Gerais, Brazil, CEP: 35400-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldo Ce\u0301lio","family":"Branda\u0303o","sequence":"additional","affiliation":[{"name":"Campus Universita\u0301rio, Morro do Cruzeiro , , s\/n, Vila Itacolomi , , ,","place":["Ouro Preto, Minas Gerais, Brazil, CEP: 35400-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2500-0798","authenticated-orcid":true,"given":"Cintia Lopes de Brito","family":"Magalha\u0303es","sequence":"additional","affiliation":[{"name":"Campus Universita\u0301rio, Morro do Cruzeiro , , s\/n, Vila Itacolomi , , ,","place":["Ouro Preto, Minas Gerais, Brazil, CEP: 35400-000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7691-3186","authenticated-orcid":true,"given":"Jose\u0301 Carlos","family":"de Magalha\u0303es","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sa\u0303o Joa\u0303o del-Rei Campus Alto Paraopeba , , Rod. 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Flavonoids as\nAntiviral Agents for Enterovirus A71 (EV-A71) Viruses (2020) 12 (184)","volume":"12","author":"Lalani","year":"2020","journal-title":"Viruses"},{"issue":"2","key":"2026072810095402300_cit8","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3390\/v11020175","article-title":"Tropism of the Chikungunya Virus","volume":"11","author":"Matusali","year":"2019","journal-title":"Viruses"},{"key":"2026072810095402300_cit9","doi-asserted-by":"publisher","first-page":"716","DOI":"10.17179\/excli2023-6242","article-title":"Antiviral\nActivity\nof Myricetin Glycosylated Compounds Isolated from Marcetia Taxifolia against Chikungunya Virus","volume":"22","author":"Mun\u0303oz","year":"2023","journal-title":"EXCLI J."},{"key":"2026072810095402300_cit10","unstructured":"Ministe\u0301rio da Sau\u0301de.\n          \n          Painel de Monitoramento\ndas Arboviroses -\nMiniste\u0301rio da Sau\u0301de Casos prova\u0301veis de Chikungunya, 2025 (accessed 2026\u201304\u201327)."},{"key":"2026072810095402300_cit11","unstructured":"Ministe\u0301rio da Sau\u0301de.\n          \n          Nota Te\u0301cnica\nN\u00b0 9\/2026-CGFAM\/DPNI\/SVSA\/MS. 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