{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:59:19Z","timestamp":1791302359445,"version":"4.1.0"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"39","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012906","name":"Department of Education of Shandong Province","doi-asserted-by":"publisher","award":["Z2024056"],"award-info":[{"award-number":["Z2024056"]}],"id":[{"id":"10.13039\/100012906","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cholesteryl ester deposition in atherosclerosis (AS) plaques drives lipid core formation and plaque instability. Traditional statin drugs lack targeting and cause adverse reactions in some patients. This study proposed a potential localized laser-based physical intervention strategy based on photon-phonon resonant absorption (PPRA). We assigned the vibrational modes of four cholesteryl esters: cholesteryl linoleate (CLA), cholesteryl oleate (COA), cholesteryl palmitate (CPA), and cholesteryl stearate (CSA) using first-principles density functional theory, and determined the C\u2550O vibration frequencies (1720\u20131750 cm\u20131). We suggested using a 52 THz laser to selectively excite C\u2550O bond resonance, thereby could be used for PPRA-based intervention. It is predicted to disrupt cholesteryl ester intermolecular hydrogen-bond acceptor interactions, potentially promoting a transition from ordered (solid\/liquid-crystalline) to more disordered (liquid-like) states within lipid cores. Consequently, this may enhance the efficiency of esterase hydrolysis and could facilitate cholesterol reverse transport, which might help reduce lipid plaque deposition. This method offers a potential physical intervention for AS, overcoming some limitations of traditional drug-based approaches. However, rigorous experimental validation and in vivo testing are required before any clinical application of this proposed physical therapy concept.<\/jats:p>","DOI":"10.1021\/acsomega.6c02763","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:02:16Z","timestamp":1790146936000},"page":"58735-58741","source":"Crossref","is-referenced-by-count":0,"title":["DFT Simulation\nof the Vibrational Spectrum of Cholesteryl\nEsters: A New Physical Therapy Proposal for Localized Laser-Based\nClearance of Atherosclerotic Lipid Plaques"],"prefix":"10.1021","volume":"11","author":[{"given":"Yifan","family":"Guan","sequence":"first","affiliation":[{"name":"Shandong University , , ,","place":["Weihai, China, 264209"]},{"name":"Shandong University , , ,","place":["Weihai, China, 264209"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong University , , ,","place":["Weihai, China, 264209"]},{"name":"Shandong University , , ,","place":["Weihai, China, 264209"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong University , , ,","place":["Weihai, China, 264209"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Xia","sequence":"additional","affiliation":[{"name":"Shandong University , , ,","place":["Weihai, China, 264209"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengfei","family":"Wen","sequence":"additional","affiliation":[{"name":"Shandong University , , ,","place":["Weihai, China, 264209"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong University , , ,","place":["Weihai, China, 264209"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong University , , ,","place":["Weihai, China, 264209"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-6310","authenticated-orcid":true,"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong University , , ,","place":["Weihai, China, 264209"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"6","key":"2026100610493777000_cit1","doi-asserted-by":"publisher","first-page":"3346","DOI":"10.3390\/ijms23063346","article-title":"Pathophysiology of atherosclerosis","volume":"23","author":"Jebari-Benslaiman","year":"2022","journal-title":"Int. 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December 20, 2020. https:\/\/www.spectroscopyonline.com\/view\/co-bond-part-vi-esters-and-rule-three."},{"issue":"2","key":"2026100610493777000_cit33","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.vibspec.2003.11.003","article-title":"First investigations\nof two important\ncomponents of low density lipoproteins by Raman spectroscopy: the\ncholesteryl linoleate and arachidonate","volume":"34","author":"Bresson","year":"2004","journal-title":"Vib.\nSpectrosc."},{"issue":"2","key":"2026100610493777000_cit34","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s13346-017-0360-0","article-title":"Exploring unsaturated\nfatty acid cholesteryl esters as transdermal permeation enhancers","volume":"7","author":"Rambharose","year":"2017","journal-title":"Drug Delivery Transl. Res."},{"issue":"9","key":"2026100610493777000_cit35","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1021\/ac60141a008","article-title":"Cholesteryl esters\nof Long-Chain\nfatty acids. infrared spectra and separation by paper chromatography","volume":"30","author":"Labarrere","year":"1958","journal-title":"Anal. Chem."},{"key":"2026100610493777000_cit36","doi-asserted-by":"publisher","first-page":"12390","DOI":"10.1021\/acs.jpcb.5b06541","article-title":"Modeling Vibrational Spectra of Ester Carbonyl Stretch\nin Water and DMSO Based on Molecular Dynamics Simulation","volume":"119","author":"Fang","year":"2015","journal-title":"J. Phys. Chem. B"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c02763","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/39\/58735\/68612606\/acsomega.6c02763.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/39\/58735\/68612606\/acsomega.6c02763.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:25:19Z","timestamp":1791300319000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/11\/39\/58735\/5436107\/DFT-Simulation-of-the-Vibrational-Spectrum-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":36,"journal-issue":{"issue":"39","published-online":{"date-parts":[[2026,9,23]]},"published-print":{"date-parts":[[2026,10,6]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c02763","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]}}}