{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:27:10Z","timestamp":1787074030456,"version":"build-2736575974"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda????o de Amparo ?? Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00068-18"],"award-info":[{"award-number":["APQ-00068-18"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda????o de Amparo ?? 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Annona coriacea Mart., a plant native to the Brazilian Cerrado, is a source of bioactive acetogenins. In this study, we evaluated the antitumor effects of acetogenin-enriched fractions from A. coriacea using in vitro and in vivo models of HNC. The fractions exhibited cytotoxic activity against FaDu and HN13 cells, with IC50 values ranging from 2.42 to 8.25 \u03bcg\/mL and from 1.61 to 12.57 \u03bcg\/mL, respectively, while showing lower toxicity toward nontumor cells. Mechanistic analyses suggested the involvement of mitochondrial-associated apoptotic-like and necroptotic cell death processes. Molecular docking analyses indicated a possible modulatory interaction between acetogenins and tumor necrosis factor receptor 1 (TNFR1). In vivo, the selected fraction ACL3 reduced tumor growth and angiogenesis in the CAM model without inducing vascular irritation, as confirmed by the HET-CAM assay. Together, these findings demonstrate that A. coriacea acetogenin-rich fractions exhibit selective antitumor activity, induce mitochondrial-mediated and necroptosis-related cell death mechanisms, and inhibit tumor-associated angiogenesis, supporting their potential as promising candidates for further preclinical investigation in HNC.<\/jats:p>","DOI":"10.1021\/acsomega.6c02820","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:06:48Z","timestamp":1785935208000},"page":"47754-47764","source":"Crossref","is-referenced-by-count":0,"title":["Acetogenins from\n                    <i>Annona coriacea<\/i>\n                    Target TNFR1-Mediated Cell Death\nin Head and Neck Cancer"],"prefix":"10.1021","volume":"11","author":[{"given":"Gilva\u0302nia Aparecida Rabelo","family":"Cordeiro","sequence":"first","affiliation":[{"name":"Universidade Federal de Sao Joao Del-Rei - Campus Centro-Oeste Dona Lindu , , ,","place":["Divino\u0301polis, Minas Gerais, Brazil, 35501-296"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Gabriela Silva","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sao Joao Del-Rei - Campus Centro-Oeste Dona Lindu , , ,","place":["Divino\u0301polis, Minas Gerais, Brazil, 35501-296"]},{"name":"Universidade de Itauna , , ,","place":["Itau\u0301na, Minas Gerais, Brazil, 35680-142"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joa\u0303o Gabriel Morais","family":"Junqueira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goia\u0301s , , , ,","place":["Goia\u0302nia, Goia\u0301s, Brazil, 74605-220"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Raspanti Sousa","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sao Joao Del-Rei - Campus Centro-Oeste Dona Lindu , , ,","place":["Divino\u0301polis, Minas Gerais, Brazil, 35501-296"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5965-3191","authenticated-orcid":true,"given":"Arlan","family":"da Silva Gonc\u0327alves","sequence":"additional","affiliation":[{"name":"Federal Institute of Education, Science and Technology, Department of Chemistry , , ,","place":["Vila Velha, Espirito Santo, Brazil, 29106-010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefani Alves","family":"Asevedo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sao Joao Del-Rei - Campus Centro-Oeste Dona Lindu , , ,","place":["Divino\u0301polis, Minas Gerais, Brazil, 35501-296"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo E. M.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sao Joao Del-Rei - Campus Centro-Oeste Dona Lindu , , ,","place":["Divino\u0301polis, Minas Gerais, Brazil, 35501-296"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-7940","authenticated-orcid":true,"given":"Rui","family":"Reis","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center , , ,","place":["Barretos, Brazil, 14784-400"]},{"name":"Universidade Do Minho Instituto de Investigacao Em Ciencias da Vida E Saude , ,","place":["Braga, Portugal, 4710-057"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5384-6657","authenticated-orcid":true,"given":"Vanessa G.","family":"Pasqualotto Severino","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goia\u0301s , , , ,","place":["Goia\u0302nia, Goia\u0301s, Brazil, 74605-220"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph Gruppi","family":"Thome\u0301","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sao Joao Del-Rei - Campus Centro-Oeste Dona Lindu , , ,","place":["Divino\u0301polis, Minas Gerais, Brazil, 35501-296"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He\u0301lio Batista","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sao Joao Del-Rei - Campus Centro-Oeste Dona Lindu , , ,","place":["Divino\u0301polis, Minas Gerais, Brazil, 35501-296"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7374-4743","authenticated-orcid":true,"given":"Rosy Iara Maciel de Azambuja","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sao Joao Del-Rei - Campus Centro-Oeste Dona Lindu , , ,","place":["Divino\u0301polis, Minas Gerais, Brazil, 35501-296"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"issue":"10","key":"2026081810494863900_cit1","doi-asserted-by":"publisher","first-page":"922","DOI":"10.3390\/v11100922","article-title":"A Current\nUpdate on Human Papillomavirus-Associated Head and Neck Cancers","volume":"11","author":"Tumban","year":"2019","journal-title":"Viruses"},{"issue":"1","key":"2026081810494863900_cit2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.13005\/bpj\/1608","article-title":"Review\non Pharmacology of Cisplatin: Clinical Use, Toxicity and Mechanism\nof Resistance of Cisplatin","volume":"12","author":"Aldossary","year":"2019","journal-title":"Biomed. 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