{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:02:25Z","timestamp":1785250945614,"version":"3.55.0"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"29","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015872","name":"Universit? de Lille","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010095","name":"R?gion Hauts-de-France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010095","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lesaffre International"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The yeast cell wall (YCW) is a dynamic and multifunctional structure that is essential for cellular integrity, stress resistance, and interactions with the surrounding environment. Its structural composition is strongly influenced by external factors, such as temperature, pH, and nutrients. In batch cultures, yeast grows in a closed system with limited nutrients, resulting in distinct growth phases that are associated with major metabolic transitions. Although the global proteomic changes during growth kinetics have been described, the temporal changes of cell wall protein (CWP) expression remain poorly understood. In this study, we investigated the kinetics of protein expression in the cell wall-enriched fraction of Saccharomyces cerevisiae S288c during a bioreactor-based batch cultivation in rich medium. A classical proteomics workflow was applied to capture the dynamic variation of protein expression at multiple time points in these fractions, with a focus on covalently linked CWPs (cCWPs). The results revealed qualitative and quantitative changes in cCWP expression correlated with metabolic shifts between growth phases. Proteins involved in cell wall remodeling and glycoprotein biosynthesis were particularly enriched at the initial sampling point, corresponding to the transition from flask cultivation to bioreactor conditions, when the overall cCWP abundance was the highest. Time-resolved quantitative proteomics, transcription factor analysis, and functional enrichment indicated the coordinated regulation of cell wall adaptation. Stationary phase-specific protein markers associated with glucose depletion were identified, providing insight into nutrient-limited cell wall remodeling.<\/jats:p>","DOI":"10.1021\/acsomega.6c02870","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:44:34Z","timestamp":1783979074000},"page":"43748-43762","source":"Crossref","is-referenced-by-count":0,"title":["Time-Resolved Proteomics Analysis of the Cell Wall-Enriched\nFraction in\n                    <i>Saccharomyces cerevisiae<\/i>\n                    S288c during Batch Fermentation"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6772-313X","authenticated-orcid":true,"given":"Marie","family":"Yammine","sequence":"first","affiliation":[{"name":"Universite\u0301 de Lille, CNRS, UAR CNRS 3290 MSAP , , ,","place":["Villeneuve d\u2019Ascq, France, F-59650"]},{"name":"Lesaffre International , , 77 Rue de Menin , ,","place":["Marquette-Lez-Lille, France, F-59520"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0226-4590","authenticated-orcid":true,"given":"Antoine","family":"Picavet","sequence":"additional","affiliation":[{"name":"Lesaffre International , , 77 Rue de Menin , ,","place":["Marquette-Lez-Lille, France, F-59520"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9768-9777","authenticated-orcid":true,"given":"Emmanuel","family":"Poilpre\u0301","sequence":"additional","affiliation":[{"name":"Lesaffre International , , 77 Rue de Menin , ,","place":["Marquette-Lez-Lille, France, F-59520"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0135-675X","authenticated-orcid":true,"given":"Ste\u0301phanie","family":"Flament","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Lille, CNRS, UAR CNRS 3290 MSAP , , ,","place":["Villeneuve d\u2019Ascq, France, F-59650"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4723-8206","authenticated-orcid":true,"given":"Fabrice","family":"Bray","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Lille, CNRS, UAR CNRS 3290 MSAP , , ,","place":["Villeneuve d\u2019Ascq, France, F-59650"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6644-434X","authenticated-orcid":true,"given":"Isabelle","family":"Mouly","sequence":"additional","affiliation":[{"name":"Lesaffre International , , 77 Rue de Menin , ,","place":["Marquette-Lez-Lille, France, F-59520"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-8860","authenticated-orcid":true,"given":"Christian","family":"Rolando","sequence":"additional","affiliation":[{"name":"Universite\u0301 de Lille, CNRS, UAR CNRS 3290 MSAP , , ,","place":["Villeneuve d\u2019Ascq, France, F-59650"]},{"name":"Shrieking sixties , 1-3 Alle\u0301e Lavoisier , ,","place":["Villeneuve d\u2019Ascq, France, F-59650"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"issue":"3","key":"2026072810113034500_cit1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.crvi.2010.12.016","article-title":"Bread, beer and wine: yeast domestication in the Saccharomyces\nsensu stricto complex","volume":"334","author":"Sicard","year":"2011","journal-title":"C. 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Biol."},{"issue":"5287","key":"2026072810113034500_cit2","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1126\/science.274.5287.546","article-title":"Life with\n6000 genes","volume":"274","author":"Goffeau","year":"1996","journal-title":"Science"},{"key":"2026072810113034500_cit3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/B978-0-444-52149-1.00003-3","article-title":"Yeast\nbiotechnology","volume-title":"The yeasts","author":"Johnson","year":"2011"},{"issue":"6252","key":"2026072810113034500_cit4","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1126\/science.aad2081","article-title":"Yeast cell\nfactories on the horizon","volume":"349","author":"Nielsen","year":"2015","journal-title":"Science"},{"issue":"3","key":"2026072810113034500_cit5","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1534\/genetics.111.130765","article-title":"Yeast: an experimental\norganism for 21st century biology","volume":"189","author":"Botstein","year":"2011","journal-title":"Genet"},{"issue":"1","key":"2026072810113034500_cit6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3934\/microbiol.2020001","article-title":"Saccharomyces\ncerevisiae and its industrial applications","volume":"6","author":"Parapouli","year":"2020","journal-title":"AIMS Microbiol."},{"issue":"9","key":"2026072810113034500_cit7","doi-asserted-by":"publisher","first-page":"1800421","DOI":"10.1002\/biot.201800421","article-title":"Yeast systems\nbiology: model organism and cell factory","volume":"14","author":"Nielsen","year":"2019","journal-title":"Biotechnol.\nJ."},{"issue":"7","key":"2026072810113034500_cit8","doi-asserted-by":"publisher","first-page":"fow080","DOI":"10.1093\/femsyr\/fow080","article-title":"Saccharomyces cerevisiae\nmetabolism in ecological context","volume":"16","author":"Jouhten","year":"2016","journal-title":"FEMS Yeast\nRes."},{"issue":"2","key":"2026072810113034500_cit9","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/nrmicro1949","article-title":"Reconstruction\nof biochemical networks in microorganisms","volume":"7","author":"Feist","year":"2009","journal-title":"Nat.\nRev. Microbiol."},{"issue":"1","key":"2026072810113034500_cit10","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1534\/genetics.111.135731","article-title":"Nutritional\ncontrol of growth and development in yeast","volume":"192","author":"Broach","year":"2012","journal-title":"Genet"},{"issue":"5","key":"2026072810113034500_cit11","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s004490100263","article-title":"Understanding\nthe bioreactor","volume":"24","author":"Lide\u0301n","year":"2002","journal-title":"Bioprocess Biosyst. Eng."},{"key":"2026072810113034500_cit12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1201\/b15426-6","article-title":"Advanced\nfermentation processes","volume-title":"Engineering aspects\nof food biotechnology","author":"Paulova\u0301","year":"2013"},{"issue":"11","key":"2026072810113034500_cit13","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.3390\/microorganisms10112226","article-title":"Nutrient-limited\noperational strategies for the microbial\nproduction of biochemicals","volume":"10","author":"Rajpurohit","year":"2022","journal-title":"Microorganisms"},{"key":"2026072810113034500_cit14","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/d41586-019-02288-y","article-title":"Yeast cells\nhandle stress by reprogramming their metabolism","volume":"572","author":"Nielsen","year":"2019","journal-title":"Nature"},{"issue":"1","key":"2026072810113034500_cit15","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.biotechadv.2011.07.010","article-title":"Cell growth and cell\ncycle in Saccharomyces cerevisiae: Basic regulatory design and protein\u2013protein\ninteraction network","volume":"30","author":"Alberghina","year":"2012","journal-title":"Biotech Adv."},{"issue":"2","key":"2026072810113034500_cit16","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1128\/mr.57.2.383-401.1993","article-title":"Stationary phase\nin the yeast Saccharomyces cerevisiae","volume":"57","author":"Werner-Washburne","year":"1993","journal-title":"Microbiol.\nRev."},{"issue":"7","key":"2026072810113034500_cit17","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.3390\/microorganisms11071641","article-title":"Microbial growth under\nlimiting conditions-future perspectives","volume":"11","author":"Gonzalez","year":"2023","journal-title":"Microorganisms"},{"issue":"1","key":"2026072810113034500_cit18","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/msb.2013.11","article-title":"Temporal system-level\norganization of the switch from\nglycolytic to gluconeogenic operation in yeast","volume":"9","author":"Zampar","year":"2013","journal-title":"Mol. Syst. Biol."},{"issue":"4","key":"2026072810113034500_cit19","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1128\/JB.183.4.1441-1451.2001","article-title":"Network identification\nand flux quantification in the central metabolism of Saccharomyces\ncerevisiae under different conditions of glucose repression","volume":"183","author":"Gombert","year":"2001","journal-title":"J. Bacteriol."},{"issue":"1","key":"2026072810113034500_cit20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1074\/mcp.M400087-MCP200","article-title":"Comparative\nproteome analysis of Saccharomyces cerevisiae grown in chemostat cultures\nlimited for glucose or ethanol","volume":"4","author":"Kolkman","year":"2005","journal-title":"Mol. Cell. 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Natl.\nAcad. Sci."},{"issue":"5","key":"2026072810113034500_cit24","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1002\/bit.22868","article-title":"Integrative analysis using proteome\nand transcriptome data from yeast to unravel regulatory patterns at\npost-transcriptional level","volume":"107","author":"Olivares-Herna\u0301ndez","year":"2010","journal-title":"Biotechnol. Bioeng."},{"issue":"2","key":"2026072810113034500_cit25","doi-asserted-by":"publisher","first-page":"e01615","DOI":"10.1128\/msystems.01615-24","article-title":"An integrated\nmultiphase dynamic genome-scale model explains batch fermentations\nled by species of the Saccharomyces genus","volume":"10","author":"Moimenta","year":"2025","journal-title":"mSystems"},{"issue":"3","key":"2026072810113034500_cit26","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1046\/j.1472-765X.2003.01394.x","article-title":"A study of the yeast\ncell wall composition and structure\nin response to growth conditions and mode of cultivation","volume":"37","author":"Aguilar-Uscanga","year":"2003","journal-title":"Lett. Appl. Microbiol."},{"issue":"2\u20133","key":"2026072810113034500_cit27","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0968-4328(97)00072-3","article-title":"The ultrastructure\nof yeast: cell wall structure and formation","volume":"29","author":"Osumi","year":"1998","journal-title":"Micron"},{"issue":"4","key":"2026072810113034500_cit28","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s00294-013-0408-8","article-title":"Yeast membranes\nand cell wall: from\nbasics to applications","volume":"59","author":"Hapala","year":"2013","journal-title":"Curr. Genet."},{"issue":"3","key":"2026072810113034500_cit29","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1534\/genetics.112.144485","article-title":"Architecture\nand biosynthesis of the Saccharomyces cerevisiae cell wall","volume":"192","author":"Orlean","year":"2012","journal-title":"Genet"},{"issue":"6","key":"2026072810113034500_cit30","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.3491","article-title":"Biotechnological potential of yeast\ncell wall: An overview","volume":"40","author":"Jofre","year":"2024","journal-title":"Biotechnol. Prog."},{"issue":"20","key":"2026072810113034500_cit31","doi-asserted-by":"publisher","first-page":"4787","DOI":"10.1002\/pmic.200800951","article-title":"A three-way proteomics\nstrategy allows differential\nanalysis of yeast mitochondrial membrane protein complexes under anaerobic\nand aerobic conditions","volume":"9","author":"Helbig","year":"2009","journal-title":"Proteom"},{"issue":"1","key":"2026072810113034500_cit32","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/msb.2010.122","article-title":"Comprehensive\nquantitative analysis of central carbon and amino-acid metabolism\nin Saccharomyces cerevisiae under multiple conditions by targeted\nproteomics","volume":"7","author":"Costenoble","year":"2011","journal-title":"Mol. Syst. Biol."},{"issue":"11","key":"2026072810113034500_cit33","doi-asserted-by":"publisher","first-page":"3864","DOI":"10.1099\/mic.0.2007\/009969-0","article-title":"Quantitative proteomics and transcriptomics\nof anaerobic and aerobic yeast cultures reveals post-transcriptional\nregulation of key cellular processes","volume":"153","author":"de Groot","year":"2007","journal-title":"Microbiol"},{"issue":"23","key":"2026072810113034500_cit34","doi-asserted-by":"publisher","first-page":"13207","DOI":"10.1073\/pnas.2135385100","article-title":"The proteome\nof Saccharomyces cerevisiae mitochondria","volume":"100","author":"Sickmann","year":"2003","journal-title":"Proc.\nNatl. Acad. Sci."},{"issue":"13","key":"2026072810113034500_cit35","doi-asserted-by":"publisher","first-page":"7524","DOI":"10.1073\/pnas.1918216117","article-title":"Absolute yeast mitochondrial proteome quantification\nreveals trade-off between biosynthesis and energy generation during\ndiauxic shift","volume":"117","author":"Di Bartolomeo","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"21","key":"2026072810113034500_cit36","doi-asserted-by":"publisher","first-page":"20894","DOI":"10.1074\/jbc.M500334200","article-title":"Comprehensive\nProteomic Analysis of Saccharomyces cerevisiae\nCell Walls: identification of proteins covalently attached via glycosylphosphatidylinositol\nremnants or mild alkali-sensitive linkages","volume":"280","author":"Yin","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"4","key":"2026072810113034500_cit37","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1021\/pr4010019","article-title":"Enhanced FASP (eFASP) to increase\nproteome coverage and sample recovery for quantitative proteomic experiments","volume":"13","author":"Erde","year":"2014","journal-title":"J. Proteome Res."},{"issue":"D1","key":"2026072810113034500_cit38","doi-asserted-by":"publisher","first-page":"D642","DOI":"10.1093\/nar\/gkz859","article-title":"YEASTRACT+: a portal for cross-species comparative\ngenomics of transcription regulation in yeasts","volume":"48","author":"Monteiro","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"2026072810113034500_cit39","doi-asserted-by":"publisher","first-page":"D785","DOI":"10.1093\/nar\/gkac1041","article-title":"YEASTRACT+: a portal for the exploitation of\nglobal transcription regulation and metabolic model data in yeast\nbiotechnology and pathogenesis","volume":"51","author":"Teixeira","year":"2023","journal-title":"Nucleic Acids\nRes."},{"issue":"1","key":"2026072810113034500_cit40","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/1471-2105-15-293","article-title":"jvenn: an\ninteractive Venn diagram viewer","volume":"15","author":"Bardou","year":"2014","journal-title":"BMC Bioinf."},{"issue":"D1","key":"2026072810113034500_cit41","doi-asserted-by":"publisher","first-page":"D730","DOI":"10.1093\/nar\/gkae1113","article-title":"The STRING\ndatabase in 2025: protein networks with\ndirectionality of regulation","volume":"53","author":"Szklarczyk","year":"2025","journal-title":"Nucleic Acids\nRes."},{"key":"2026072810113034500_cit42","first-page":"55","article-title":"Yeast Cell\nSynchronization","volume-title":"Cell Cycle Checkpoint\nControl Protocols","author":"Day","year":"2004"},{"issue":"1","key":"2026072810113034500_cit43","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.tim.2005.11.009","article-title":"Non-conventional\nprotein secretionin yeast","volume":"14","author":"Nombela","year":"2006","journal-title":"Trends Microbiol."},{"issue":"D1","key":"2026072810113034500_cit44","doi-asserted-by":"publisher","first-page":"D642","DOI":"10.1093\/nar\/gkz859","article-title":"YEASTRACT+: a portal for cross-species comparative\ngenomics of transcription regulation in yeasts","volume":"48","author":"Monteiro","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"2026072810113034500_cit45","doi-asserted-by":"publisher","first-page":"D785","DOI":"10.1093\/nar\/gkac1041","article-title":"YEASTRACT+: a portal for the exploitation of\nglobal transcription regulation and metabolic model data in yeast\nbiotechnology and pathogenesis","volume":"51","author":"Teixeira","year":"2023","journal-title":"Nucleic Acids\nRes."},{"key":"2026072810113034500_cit46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4061\/2011\/356093","article-title":"Acid phosphatases\nof budding yeast as a model of choice for transcription regulation\nresearch","volume":"2011","author":"Sambuk","year":"2011","journal-title":"Enzyme Res."},{"issue":"2","key":"2026072810113034500_cit47","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1128\/MMBR.05018-11","article-title":"Biology of the heat\nshock response and protein chaperones: budding yeast (Saccharomyces\ncerevisiae) as a model system","volume":"76","author":"Verghese","year":"2012","journal-title":"Microbiol. Mol.\nBiol. Rev."},{"key":"2026072810113034500_cit48","doi-asserted-by":"publisher","first-page":"110746","DOI":"10.1016\/j.foodhyd.2024.110746","article-title":"Yeast cell\nwall-derived proteins: Identification and characterization as food\nemulsifiers","volume":"160","author":"Saito","year":"2025","journal-title":"Food Hydrocolloids"},{"issue":"6","key":"2026072810113034500_cit49","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1128\/EC.00004-11","article-title":"The F-Box Protein Fbp1 Regulates\nSexual Reproduction and Virulence\nin Cryptococcus neoformans","volume":"10","author":"Liu","year":"2011","journal-title":"Eukaryotic Cell"},{"issue":"34","key":"2026072810113034500_cit50","doi-asserted-by":"publisher","first-page":"29702","DOI":"10.1021\/acsomega.2c02176","article-title":"Reliable approach for\npure yeast cell wall protein isolation from Saccharomyces cerevisiae\nyeast cells","volume":"7","author":"Yammine","year":"2022","journal-title":"ACS Omega"},{"key":"2026072810113034500_cit51","doi-asserted-by":"publisher","first-page":"112448","DOI":"10.1016\/j.foodhyd.2026.112448","article-title":"Understanding\nthe variability in\ncell wall composition and related properties of industrial spent yeasts\nfrom brewing and winemaking","volume":"175","author":"Croonen","year":"2026","journal-title":"Food Hydrocolloids"},{"issue":"18","key":"2026072810113034500_cit52","doi-asserted-by":"publisher","first-page":"5802","DOI":"10.1128\/jb.176.18.5802-5813.1994","article-title":"Protein synthesis\nin long-term stationary-phase\ncultures of Saccharomyces cerevisiae","volume":"176","author":"Fuge","year":"1994","journal-title":"J. Bacteriol."},{"issue":"6","key":"2026072810113034500_cit53","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1111\/j.1365-2958.1996.tb02461.x","article-title":"Stationary phase\nin Saccharomyces cerevisiae","volume":"19","author":"Werner-Washburne","year":"1996","journal-title":"Mol. Microbiol."},{"issue":"9","key":"2026072810113034500_cit54","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.4161\/cc.19879","article-title":"Staying alive","volume":"11","author":"Valcourt","year":"2012","journal-title":"Cell Cycle"},{"issue":"1","key":"2026072810113034500_cit55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/jof4010001","article-title":"The CWI Pathway: Regulation of the Transcriptional\nAdaptive Response to Cell Wall Stress in Yeast","volume":"4","author":"Sanz","year":"2018","journal-title":"J. Fungi (Basel)"},{"issue":"21","key":"2026072810113034500_cit56","doi-asserted-by":"publisher","first-page":"7051","DOI":"10.1007\/s00253-022-12207-3","article-title":"Protective\neffects of peptides on the cell wall structure of yeast under osmotic\nstress","volume":"106","author":"Jin","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"2026072810113034500_cit57","doi-asserted-by":"publisher","first-page":"953479","DOI":"10.3389\/fmicb.2022.953479","article-title":"The cell wall and the response and\ntolerance to stresses of biotechnological relevance in yeasts","volume":"13","author":"Ribeiro","year":"2022","journal-title":"Front. Microbiol."}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c02870","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/29\/43748\/65898147\/acsomega.6c02870.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/29\/43748\/65898147\/acsomega.6c02870.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:40:55Z","timestamp":1785249655000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/11\/29\/43748\/5207698\/Time-Resolved-Proteomics-Analysis-of-the-Cell-Wall"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":57,"journal-issue":{"issue":"29","published-online":{"date-parts":[[2026,7,13]]},"published-print":{"date-parts":[[2026,7,28]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c02870","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]}}}