{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:12:57Z","timestamp":1788437577024,"version":"build-2803163510"},"reference-count":29,"publisher":"American Chemical Society (ACS)","issue":"34","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/na","name":"Medical Scientific Research Project of Changzhou Health Commission","doi-asserted-by":"publisher","award":["No. ZD202207"],"award-info":[{"award-number":["No. ZD202207"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aortic dissection (AD) is a life-threatening cardiovascular disease with an extremely high mortality rate. Excessive reactive oxygen species (ROS) production and inflammatory responses in diseased vascular regions are central drivers of AD pathogenesis, leading to destruction of the aortic wall structure and fatal hemorrhage. However, conventional clinical therapies for AD cannot effectively eliminate excessive ROS at lesion sites while simultaneously exerting anti-inflammatory effects. To address these limitations, we developed a biomimetic, inflammation-targeting nanoparticle, ZIF-8@Res@PEG-FA (ZRF), to attenuate AD progression through potent antioxidant and anti-inflammatory interventions. ZRF is constructed with ZIF-8 as the core carrier, loaded with the antioxidant and anti-inflammatory agent resveratrol, and surface-modified with PEG-folic acid (PEG-FA). This nanoparticle enhances resveratrol bioavailability and leverages the inflammation-targeting capability of folic acid to preferentially accumulate in AD lesions. Under mildly acidic conditions, ZRF rapidly degrades and efficiently scavenges ROS, disrupting the oxidative stress\u2013inflammation vicious cycle and promoting the polarization of pro-inflammatory M1 macrophages toward the anti-inflammatory M2 phenotype. Notably, ZRF also preserves the contractile phenotype of vascular smooth muscle cells (VSMCs), maintains extracellular matrix stability, and thereby delays AD progression. This study presents a promising therapeutic strategy for aortic dissection and other inflammatory vascular diseases.<\/jats:p>","DOI":"10.1021\/acsomega.6c02956","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:01:48Z","timestamp":1786975308000},"page":"50992-51003","source":"Crossref","is-referenced-by-count":0,"title":["Targeted Catalytic\nAnti-Inflammatory and Antioxidant\nTherapy for Aortic Dissection Using Biomimetic Nanomaterials"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9459-6516","authenticated-orcid":true,"given":"Hongwei","family":"Ge","sequence":"first","affiliation":[{"name":"The Third Affiliated Hospital of Soochow University , ,","place":["Chang Zhou, China, 213003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Soochow University , ,","place":["Chang Zhou, China, 213003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyang","family":"Li","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Soochow University , ,","place":["Chang Zhou, China, 213003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Di","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Soochow University , ,","place":["Chang Zhou, China, 213003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Huang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Soochow University , ,","place":["Chang Zhou, China, 213003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Soochow University , ,","place":["Chang Zhou, China, 213003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Huang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Soochow University , ,","place":["Chang Zhou, China, 213003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Soochow University , ,","place":["Chang Zhou, China, 213003"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"issue":"10378","key":"2026090307162598900_cit1","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/S0140-6736(22)01970-5","article-title":"Acute aortic dissection","volume":"401","author":"Carrel","year":"2023","journal-title":"Lancet"},{"issue":"2","key":"2026090307162598900_cit2","doi-asserted-by":"publisher","DOI":"10.31083\/RCM26807","article-title":"Questions and Certainty\nin Diagnosis and Management of Acute Type B Aortic Dissection","volume":"26","author":"Lovato","year":"2025","journal-title":"Rev. Cardiovasc. Med."},{"issue":"9","key":"2026090307162598900_cit3","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2909318","article-title":"Developing and Verifying\nan Effective Diagnostic Model Linked to Immune Infiltration in Stanford\nType A Aortic Dissection","volume":"29","author":"Huang","year":"2024","journal-title":"Front. Biosci."},{"issue":"12","key":"2026090307162598900_cit4","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1161\/CIRCULATIONAHA.123.063332","article-title":"Epigenetic\nInduction of Smooth Muscle Cell Phenotypic Alterations in Aortic Aneurysms\nand Dissections","volume":"148","author":"Chakraborty","year":"2023","journal-title":"Circulation"},{"issue":"10","key":"2026090307162598900_cit5","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1093\/eurheartj\/ehac757","article-title":"Acute aortic dissection: evidence,\nuncertainties, and future therapies","volume":"44","author":"Rylski","year":"2023","journal-title":"Eur. Heart\nJ."},{"issue":"4","key":"2026090307162598900_cit6","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1002\/ptr.7754","article-title":"Resveratrol\nregulates inflammation and improves oxidative stress via Nrf2 signaling\npathway: Therapeutic and biotechnological prospects","volume":"37","author":"Shahcheraghi","year":"2023","journal-title":"Phytother Res."},{"issue":"11","key":"2026090307162598900_cit7","doi-asserted-by":"publisher","DOI":"10.3390\/nu9111201","article-title":"Epigenetic\nRegulatory Mechanisms Induced by Resveratrol","volume":"9","author":"Fernandes","year":"2017","journal-title":"Nutrients"},{"issue":"1","key":"2026090307162598900_cit8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.5599\/admet.2057","article-title":"Metal-organic\nframeworks: Drug delivery applications and future prospects","volume":"12","author":"Mhettar","year":"2023","journal-title":"ADMET DMPK"},{"key":"2026090307162598900_cit9","doi-asserted-by":"publisher","first-page":"14891","DOI":"10.2147\/JIR.S539938","article-title":"Lactylation-Related Gene CALM1 Promotes Aortic Dissection via Immune\nMicroenvironment Remodeling: Insights from Bioinformatics and Clinical\nEvidence","volume":"18","author":"Yu","year":"2025","journal-title":"J. Inflamm Res."},{"issue":"29","key":"2026090307162598900_cit10","doi-asserted-by":"publisher","first-page":"6802","DOI":"10.1039\/D3TB00505D","article-title":"Metal-organic frameworks (MOFs) as\napt luminescent probes for the detection of biochemical analytes","volume":"11","author":"Luo","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"2026090307162598900_cit11","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jconrel.2024.08.011","article-title":"ZIF-8-modified\nhydrogel sequentially delivers angiogenic and osteogenic growth factors\nto accelerate vascularized bone regeneration","volume":"374","author":"Niu","year":"2024","journal-title":"J. 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Des"}],"container-title":["ACS Omega"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsomega.6c02956","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/34\/50992\/66628844\/acsomega.6c02956.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acsodf\/article-pdf\/11\/34\/50992\/66628844\/acsomega.6c02956.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:16:35Z","timestamp":1788434195000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acsodf\/article\/11\/34\/50992\/5260865\/Targeted-Catalytic-Anti-Inflammatory-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":29,"journal-issue":{"issue":"34","published-online":{"date-parts":[[2026,8,17]]},"published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1021\/acsomega.6c02956","relation":{},"ISSN":["2470-1343"],"issn-type":[{"value":"2470-1343","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]}}}