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In this study, a peptide-based nanostructured electrochemical biosensor was developed on a screen-printed electrode platform, enabling a disposable sensing strategy suitable for on-site applications. A copeptin-specific peptide, synthesized for this study, was employed as the biorecognition element to provide binding sites for the target. The UiO-66-NH2 metal\u2013organic framework was synthesized to improve the electrochemical response and served as a functional interface due to its high surface area. The proposed biosensor platform provides a sensitive detection of copeptin with a limit of detection of 228.5 pg\/mL, offering a promising low-cost and efficient peptide-based electrochemical sensing platform.<\/jats:p>","DOI":"10.1021\/acsomega.6c02983","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:02:04Z","timestamp":1789030924000},"page":"55221-55229","source":"Crossref","is-referenced-by-count":0,"title":["Nanostructured Electrochemical Biosensor for Highly\nSensitive Copeptin Detection as a Cardiac Biomarker"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9168-8960","authenticated-orcid":true,"given":"Duygu","family":"Nuhog\u0306lu","sequence":"first","affiliation":[{"name":"Istanbul Technical University , , Maslak, ,","place":["Istanbul, Tu\u0308rkiye, 34469"]},{"name":"TUBITAK , , P.O. 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