{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:24:14Z","timestamp":1787073854121,"version":"build-2736575974"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda??o de Amparo ? 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By incorporating PCL5000-PEG5000 into DSPE-PEG2000 at 99.5:0.5 and 99:1 molar ratios, we aimed to enhance drug loading and biocompatibility. The resulting systems were characterized using a range of physicochemical and biological characterization. The system achieved a low critical micelle concentration (CMC) of 1.9 \u00d7 10\u20135 mol\/L, ensuring stability upon dilution. Optimized formulations (99.5:0.5 and 99:1 molar ratios) exhibited a small hydrodynamic diameter (\u223c11 nm) and near-neutral zeta potential. Small-range X-ray scattering (SAXS) analysis confirmed a spheroidal core\u2013shell structure, where the addition of 0.5% PCL5000-PEG5000 increased drug loading capacity to 3.1 \u00b1 0.05% w\/w. Thermal analysis confirmed the successful integration of copolymers and their thermal stability. Notably, the cytotoxicity of this formulation was comparable to that of commercial formulations, while exhibiting negligible hemolysis (&amp;lt;2%), indicating a substantially improved safety profile compared with Cremophor-based vehicles. These findings highlight the potential of these mixed micelles as a biocompatible, high-capacity delivery platform for intravenous cancer chemotherapy.<\/jats:p>","DOI":"10.1021\/acsomega.6c03082","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:01:52Z","timestamp":1785859312000},"page":"47765-47778","source":"Crossref","is-referenced-by-count":0,"title":["Mixed Polymeric\nMicelles for Paclitaxel Delivery:\nPreparation and Characterization"],"prefix":"10.1021","volume":"11","author":[{"given":"Gisele L.","family":"Maia","sequence":"first","affiliation":[{"name":"Federal University of Minas Gerais , , Av. Anto\u0302nio Carlos, 6627 , , ,","place":["Belo Horizonte, Minas Gerais, Brazil, 31270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5487-1046","authenticated-orcid":true,"given":"Anna Carolina S.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais , , Av. Anto\u0302nio Carlos, 6627 , , ,","place":["Belo Horizonte, Minas Gerais, Brazil, 31270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina X.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais , , Av. Anto\u0302nio Carlos, 6627 , , ,","place":["Belo Horizonte, Minas Gerais, Brazil, 31270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8703-4283","authenticated-orcid":true,"given":"Angelo","family":"Malachias","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais , , Av. Anto\u0302nio Carlos, 6627 , , ,","place":["Belo Horizonte, Minas Gerais, Brazil, 31270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Victoria H.","family":"Machado","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais , , Av. Anto\u0302nio Carlos, 6627 , , ,","place":["Belo Horizonte, Minas Gerais, Brazil, 31270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-2343","authenticated-orcid":true,"given":"Maria Beta\u0302nia F.","family":"Marques","sequence":"additional","affiliation":[{"name":"Federal University of Alfenas , , , ,","place":["Alfenas, Minas Gerais, Brazil, 37130-001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M. R.","family":"Oda","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais , , Av. Anto\u0302nio Carlos, 6627 , , ,","place":["Belo Horizonte, Minas Gerais, Brazil, 31270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7641-6585","authenticated-orcid":true,"given":"Andre\u0301 L.","family":"B.de Barros","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais , , Av. Anto\u0302nio Carlos, 6627 , , ,","place":["Belo Horizonte, Minas Gerais, Brazil, 31270-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8812-3811","authenticated-orcid":true,"given":"Elaine A.","family":"Leite","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais , , Av. 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