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Species of Satureja are known to exhibit anti-inflammatory properties. Monoterpene phenol dimers with biphenyl skeletons have been identified in these plants and structural investigations revealed the key role of the biphenyl scaffold in interacting with MAPEG family proteins. Thus, in the present contribution, we investigated by biochemical and cell-based assays, together with molecular docking and molecular dynamics investigations, the modulation of inflammatory mediators of three isolated monoterpene phenol dimers (1\u20133). Molecular modeling and in vitro enzymatic assays of 1\u20133 against soluble epoxide hydrolase (sEH) and 5-lipoxygenase (5-LOX) identified the structural elements accountable for binding vs the biological targets. Unlike 2 and 3, in vitro experiments revealed that 1 did not show cytotoxicity. Interestingly, 1 selectively alters the profile of AA-derived mediators produced by LPS-activated macrophages, suppressing both IL-6 and PGE2. The obtained results revealed how compound 1 may not only suppress inflammation but also promote the active resolution of inflammatory responses and, by integrating computational analysis, provide clues to design more effective analogues.<\/jats:p>","DOI":"10.1021\/acsomega.6c03194","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T06:01:58Z","timestamp":1788760918000},"page":"55272-55285","source":"Crossref","is-referenced-by-count":0,"title":["Anti-Inflammatory Activity of Monoterpene Phenol Dimers\nfrom\n                    <i>Satureja bachtiarica<\/i>"],"prefix":"10.1021","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4688-1080","authenticated-orcid":true,"given":"Simone","family":"Di Micco","sequence":"first","affiliation":[{"name":"European Biomedical Research Institute of Salerno (EBRIS) , Via Salvatore De Renzi 50 , ,","place":["Salerno, Italy, 84125"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Masullo","sequence":"additional","affiliation":[{"name":"University of Salerno , , Via Giovanni Paolo II 132 , , ,","place":["Fisciano, Salerno, Italy, 84084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Marigliano","sequence":"additional","affiliation":[{"name":"University of Naples Federico II , , Via Domenico Montesano 49 , ,","place":["Naples, Italy, 80131"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Colarusso","sequence":"additional","affiliation":[{"name":"University of Salerno , , Via Giovanni Paolo II 132 , , ,","place":["Fisciano, Salerno, Italy, 84084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh Rahmani","family":"Samani","sequence":"additional","affiliation":[{"name":"University of Salerno , , Via Giovanni Paolo II 132 , , ,","place":["Fisciano, Salerno, Italy, 84084"]},{"name":"Universita\u0300 degli Studi di Salerno , , via Giovanni Paolo II n.132 , , ,","place":["Fisciano, Salerno, Italy, 84084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Schettino","sequence":"additional","affiliation":[{"name":"University of Naples Federico II , , Via Domenico Montesano 49 , ,","place":["Naples, Italy, 80131"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anella","family":"Saviano","sequence":"additional","affiliation":[{"name":"University of Naples Federico II , , Via Domenico Montesano 49 , ,","place":["Naples, Italy, 80131"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Maione","sequence":"additional","affiliation":[{"name":"University of Naples Federico II , , Via Domenico Montesano 49 , ,","place":["Naples, Italy, 80131"]},{"name":"University of Naples Federico II , , Via Domenico Montesano 49 , ,","place":["Naples, Italy, 80131"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4998-2311","authenticated-orcid":true,"given":"Sonia","family":"Piacente","sequence":"additional","affiliation":[{"name":"University of Salerno , , Via Giovanni Paolo II 132 , , ,","place":["Fisciano, Salerno, Italy, 84084"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1788-5170","authenticated-orcid":true,"given":"Giuseppe","family":"Bifulco","sequence":"additional","affiliation":[{"name":"University of Salerno , , Via Giovanni Paolo II 132 , , ,","place":["Fisciano, Salerno, Italy, 84084"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"2026092210564828800_cit1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.fitote.2015.06.012","article-title":"A new bioactive monoterpene-flavonoid\nfrom Satureja khuzistanica","volume":"105","author":"Malmir","year":"2015","journal-title":"Fitoterapia"},{"key":"2026092210564828800_cit2","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3109\/13880209.2015.1043560","article-title":"A pharmacological\nand phytochemical overview on Satureja","volume":"54","author":"Tepe","year":"2016","journal-title":"Pharm. 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